Dysregulated cholinergic transmission contributes to aging of the lower motor system

胆碱能传输失调导致下运动系统老化

• 批准号: 9565885
• 负责人: Gregorio Valdez
• 金额: $ 39.4万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9565885
• 关键词: Acetylcholine; Address; Adult; Affect; Age; Aging; Amyotrophic Lateral Sclerosis; Axon; Biological Markers; Cachexia; Data; Dendrites; Disease; Functional disorder; Gene Expression; Genes; Goals; Grant; Health; Incidence; Knowledge; Light; Longevity; Mitochondria; Molecular; Motor; Motor Neurons; Mus; Muscle; Muscle Fibers; Muscular Atrophy; Muscular Dystrophies; Natural regeneration; Neuromuscular Junction; Outcome; Pathway interactions; Pharmacology; Renshaw Cell; Research; Schwann Cells; Site; Skeletal Muscle; Source; Spinal Cord; Synapses; Synaptic Cleft; Synaptic Vesicles; System; Testing; Therapeutic; Transgenic Mice; Wild Type Mouse; age related; aged; base; cholinergic; cholinergic synapse; experimental study; falls; insight; motor deficit; motor neuron degeneration; motor neuron function; mouse model; mutant; neuromuscular function; neuromuscular system; neuronal cell body; normal aging; novel; novel marker; prevent; repaired; skeletal muscle wasting; synaptic function; tool; transmission process; vesamicol; young adult

Project Summary/ Abstract The loss of motor function that occurs with aging is closely associated with adverse health outcomes. To date, the contribution of different components of the motor system to age-related motor deficits remains unknown and despite extensive efforts. In addition, there are no therapeutics that can prevent the cellular and molecular changes that underlie loss of motor function with aging. The purpose of this proposal is to identify the contribution of the neuromuscular system to loss of motor function. We also seek to identify and test factors that function to maintain healthy skeletal muscles and motor neurons in the spinal cord, and thus preserve motor function. Specifically, we will determine whether maintaining normal levels of acetylcholine, genetically and pharmacologically, is sufficient to slow aging of skeletal muscle and motor neurons.

项目摘要/摘要