Dysregulated cholinergic transmission contributes to aging of the lower motor system

项目摘要/摘要 随着年龄增长而出现的运动功能丧失与健康不良密切相关。 结果。迄今为止，运动系统的不同组成部分对年龄相关的贡献 尽管作出了广泛的努力，但运动障碍仍然未知。此外，还没有 可以防止导致运动丧失的细胞和分子变化的治疗 随着年龄的增长而发挥作用。这项建议的目的是确定 神经肌肉系统导致运动功能丧失。我们还试图确定和测试以下因素 维持脊髓中健康的骨骼肌和运动神经元的功能，因此 保留运动功能。具体地说，我们将确定是否保持正常的 从遗传学和药理学上讲，乙酰胆碱足以延缓骨骼肌的衰老。 和运动神经元。

Project Summary/ Abstract The loss of motor function that occurs with aging is closely associated with adverse health outcomes. To date, the contribution of different components of the motor system to age-related motor deficits remains unknown and despite extensive efforts. In addition, there are no therapeutics that can prevent the cellular and molecular changes that underlie loss of motor function with aging. The purpose of this proposal is to identify the contribution of the neuromuscular system to loss of motor function. We also seek to identify and test factors that function to maintain healthy skeletal muscles and motor neurons in the spinal cord, and thus preserve motor function. Specifically, we will determine whether maintaining normal levels of acetylcholine, genetically and pharmacologically, is sufficient to slow aging of skeletal muscle and motor neurons.