Regulatory Pathways of SR Protein Kinases

SR蛋白激酶的调控途径

基本信息

  • 批准号:
    9235874
  • 负责人:
  • 金额:
    $ 31.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-02-01 至 2021-01-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract: Splicing converts a single gene into multiple unique mRNA fragments to expand the size of the proteome and regulate cell function. While splicing is integral for normal function in complex organisms, mistakes in splice-selection can lead to disease. In fact, splicing errors are associated with numerous human disorders including muscular dystrophy, Alzheimer's disease, parkinsonism, cardiovascular disease, ataxias and cancers. Splicing occurs at the spliceosome, a macromolecular complex that includes both RNA and protein. In the latter group, SR proteins are essential splicing factors that control where the spliceosome assembles on precursor mRNA. SR proteins contain C-terminal domains rich in arginine-serine repeats whose polyphosphorylation controls splice-site selection. The SRPK family of protein kinases phosphorylates these RS domains directing SR proteins into the nucleus for splicing activity. While SRPKs are normally localized to the cytoplasm for this function, they can enter the nucleus under certain conditions but their function in this cellular compartment is not well understood. We will now investigate the functions of SRPKs in both the cytoplasm and nucleus using genome-wide splicing assays, cell imaging, fast-mixing kinetics, protease footprinting and structural techniques. We will determine how the unique SRPK phosphorylation mechanism governs transport of SR proteins from the cytoplasm to the nucleus. We will explore factors that regulate SRPK nuclear import through a novel kinase- kinase complex. Finally, we will investigate how this complex affects splicing reactions through the mobilization of SR proteins in the nucleus. Overall, the studies outlined in this proposal will greatly expand our knowledge of SRPK-induced phosphorylation of SR proteins and their splicing function.
项目总结/文摘:

项目成果

期刊论文数量(0)
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JOSEPH ADAMS其他文献

JOSEPH ADAMS的其他文献

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{{ truncateString('JOSEPH ADAMS', 18)}}的其他基金

Clk Kinases and Splicing Regulation
Clk 激酶和剪接调节
  • 批准号:
    8471724
  • 财政年份:
    2012
  • 资助金额:
    $ 31.78万
  • 项目类别:
Clk Kinases and Splicing Regulation
Clk 激酶和剪接调节
  • 批准号:
    8827803
  • 财政年份:
    2012
  • 资助金额:
    $ 31.78万
  • 项目类别:
Clk Kinases and Splicing Regulation
Clk 激酶和剪接调节
  • 批准号:
    8294209
  • 财政年份:
    2012
  • 资助金额:
    $ 31.78万
  • 项目类别:
Clk Kinases and Splicing Regulation
Clk 激酶和剪接调节
  • 批准号:
    8638029
  • 财政年份:
    2012
  • 资助金额:
    $ 31.78万
  • 项目类别:
Clk Kinases and Splicing Regulation
Clk 激酶和剪接调节
  • 批准号:
    9356568
  • 财政年份:
    2012
  • 资助金额:
    $ 31.78万
  • 项目类别:
Clk Kinases and Splicing Regulation
Clk 激酶和剪接调节
  • 批准号:
    9177458
  • 财政年份:
    2012
  • 资助金额:
    $ 31.78万
  • 项目类别:
Coordination of SR Protein Phosphorylation and RNA Splicing
SR 蛋白磷酸化和 RNA 剪接的协调
  • 批准号:
    7913861
  • 财政年份:
    2009
  • 资助金额:
    $ 31.78万
  • 项目类别:
Regulatory Pathways of SR Protein Kinases
SR蛋白激酶的调控途径
  • 批准号:
    8503353
  • 财政年份:
    2004
  • 资助金额:
    $ 31.78万
  • 项目类别:
Role of protein phosphorylation in RNA splicing
蛋白质磷酸化在 RNA 剪接中的作用
  • 批准号:
    6845233
  • 财政年份:
    2004
  • 资助金额:
    $ 31.78万
  • 项目类别:
Coordination of SR Protein Phosphorylation and RNA Splicing
SR 蛋白磷酸化和 RNA 剪接的协调
  • 批准号:
    7990450
  • 财政年份:
    2004
  • 资助金额:
    $ 31.78万
  • 项目类别:

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