Personality Change as an Early Marker of Alzheimer's Disease

性格改变是阿尔茨海默病的早期标志

• 批准号: 9212092
• 负责人: Antonio Terracciano
• 金额: $ 7.6万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9212092
• 关键词: Affect; Age; Aging; Agreement; Alzheimer disease detection; Alzheimer' s Disease; Autopsy; Baltimore; Behavioral; Biological; Biological Process; Brain; Caregivers; Caring; Characteristics; Clinical; Cognitive; Cohort Studies; Communities; Data; Dementia; Diagnosis; Differential Diagnosis; Dimensions; Disease Marker; Disease Progression; Distress; Early Diagnosis; Emotional; Enrollment; Evaluation; Family; Funding; Future; Genotype; Impaired cognition; Impairment; Individual; Interpersonal Relations; Intervention; Knowledge; Lead; Lewy Bodies; Longitudinal Studies; Measures; Monitor; Motivation; National Institute on Aging; Nerve Degeneration; Neurobehavioral Manifestations; Neurobiology; Neurofibrillary Tangles; Neurotic Disorders; Neurotics; Participant; Pathology; Patient Self-Report; Personality; Personality Assessment; Personality Traits; Personality inventories; Persons; Phase; Prevention; Process; Prospective Studies; Questionnaires; Research; Research Personnel; Risk Factors; Safety; Schedule; Senile Plaques; Spouses; Study Subject; Symptoms; Testing; Time; Translating; Visit; age related; apolipoprotein E-4; base; carrier status; clinical practice; healthy volunteer; in vivo; informant; interest; mild cognitive impairment; multilevel analysis; neural correlate; neuroimaging; neuropathology; novel; pre-clinical; prevent; prospective; psychologic; public health relevance; sex

 DESCRIPTION (provided by investigator): The objective of this study is to examine changes in personality traits in the preclinical phase of Alzheimer's disease (AD) and to identify early markers of the disease before the onset of dementia. Personality traits refer to the emotional, cognitive, and behavioral characteristics of a person. Changes in personality are one of the clinical criteria for the diagnosis of dementia, and changes in the five major dimensions of personality (increases in neuroticism and declines in extraversion, openness, agreeableness, and conscientiousness) have been consistently observed with the onset and progression of dementia. It is unknown, however, whether changes in the major dimensions of personality begin before the onset of dementia. For example, changes in the personality domain of conscientiousness, such as impaired motivation and loss of interest, and changes in neuroticism, such as increased emotional vulnerability and irritability, could precede the manifestation of cognitive impairments. There is thus the need for prospective, longitudinal studies to systematically examine personality change before the onset of dementia. This proposed study will examine data from the Baltimore Longitudinal Study of Aging (BLSA), an ongoing community-based cohort study. Since 1980, 1,725 participants have completed a self-reported measure of personality on multiple occasions, on average 5 assessments per person. In addition, a subset of participants had their personality rated by their spouse. BLSA participants were genotyped and their clinical and cognitive status has been evaluated at regularly scheduled visits. The BLSA includes extensive neuroimaging and an autopsy sub-study of subjects who agreed to postmortem brain examinations. This proposed study will test the hypothesis that changes in personality can be detected in the preclinical phase of AD. By examining data that span more than a decade (up to 31 years) before the onset of dementia, this study will determine at what stage and which specific personality traits change in the preclinical phase of AD. Further, the study will determine whether there are changes in personality specific to AD as compared to other dementias and whether sex and APOE Ɛ4 carrier status moderate the change in personality. In an effort to understand the neurobiological basis of personality changes, the study will also test whether personality changes are associated with the extent of AD neuropathology (amyloid plaques and neurofibrillary tangles). Thus, the proposed study provides the unprecedented opportunity to systematically evaluate the progression of personality change in the crucial preclinical phase of AD. Such changes may represent an early marker of the disease and can aid in the timely diagnosis of AD. Early detection allows the person with the condition and their family to have conversations about their wishes and make plans for future care before the worsening of decisional capacity. Early detection can also expedite the implementation of eventual prevention and treatment interventions prior to the onset of clinical dementia.

 描述（研究人员提供）：这项研究的目的是检查阿尔茨海默氏病临床前阶段（AD）的人格特征的变化，并在痴呆症发作之前鉴定疾病的早期标志。人格特征是指一个人的情感，认知和行为特征。人格变化是诊断痴呆症的临床标准之一，人格的五个主要维度（神经质的增加和外向性，开放性，开放性，同意和良心性的下降）随着痴呆症的发作和进展而始终如一地观察到。但是，尚不清楚人格的主要方面的变化是否在痴呆症发作之前开始。例如，认真度的人格领域的变化，例如动机和兴趣损失，神经质的变化，例如增加的情绪脆弱性和易怒，可能在认知障碍的表现之前。因此，需要前瞻性的纵向研究，以系统地检查痴呆症发作之前的人格变化。这项拟议的研究将研究巴尔的摩纵向研究（BLSA）的数据，这是一项正在进行的基于社区的队列研究。自1980年以来，有1,725名参与者多次完成了自我报告的人格测量，平均每人5次评估。此外，一部分参与者的性格被配偶评为。 BLSA参与者是基因分型的，他们的临床和认知状况已在定期安排的访问中进行了评估。 BLSA包括广泛的神经影像学和同意接受死后脑检查的受试者的尸检。这项拟议的研究将检验以下假设：在AD的临床前阶段可以检测到人格变化。通过检查痴呆症发作之前超过十年（长达31年）的数据，本研究将在AD的临床前阶段确定哪个阶段和哪些特定人格特征的变化。此外，该研究将确定与其他痴呆症相比，AD和APOEɛ4携带者状态是否适应人格变化是否适应AD的性格变化。为了了解人格变化的神经生物学基础，该研究还将测试人格变化是否与AD神经病理学的程度有关（淀粉样蛋白斑块和神经原纤维缠结）。这是拟议的研究提供了前所未有的机会，可以系统地评估AD关键临床前阶段中人格变化的进展。这种变化可能代表了该疾病的早期标志，可以及时诊断为AD。早期检测使情况及其家人可以就自己的意愿进行对话，并在决策能力的命运之前制定对未来护理的计划。早期发现还可以加快临床痴呆症发作之前的事件预防和治疗干预措施的实施。

项目成果

Sensory functioning and personality development among older adults.

老年人的感觉功能和个性发展。

• DOI: 10.1037/pag0000159
• 发表时间: 2017
• 期刊: Psychology and aging
• 影响因子: 3.7
• 作者: Stephan,Yannick;Sutin,AngelinaR;Bosselut,Grégoire;Terracciano,Antonio
• 通讯作者: Terracciano,Antonio

Allostatic Load and Personality: A 4-Year Longitudinal Study.

• DOI: 10.1097/psy.0000000000000281
• 发表时间: 2016-04
• 期刊: Psychosomatic medicine
• 影响因子: 3.3
• 作者: Stephan Y;Sutin AR;Luchetti M;Terracciano A
• 通讯作者: Terracciano A

Subjective Age and Dementia.

• DOI: 10.1080/07317115.2016.1187695
• 发表时间: 2017-03
• 期刊: Clinical gerontologist
• 影响因子: 2.8
• 作者: Jaconelli A;Terracciano A;Sutin AR;Sarrazin P;Raffard S;Stephan Y
• 通讯作者: Stephan Y

Personality and actigraphy-measured physical activity in older adults.

• DOI: 10.1037/pag0000158
• 发表时间: 2017-03
• 期刊: Psychology and aging
• 影响因子: 3.7
• 作者: Artese A;Ehley D;Sutin AR;Terracciano A
• 通讯作者: Terracciano A

Feeling Older and the Development of Cognitive Impairment and Dementia.

感觉变老以及认知障碍和痴呆症的发展。

• DOI: 10.1093/geronb/gbw085
• 发表时间: 2017
• 期刊: The journals of gerontology. Series B, Psychological sciences and social sciences
• 作者: Stephan,Yannick;Sutin,AngelinaR;Luchetti,Martina;Terracciano,Antonio
• 通讯作者: Terracciano,Antonio