Muscle fusion defects may be a common cause of human dystrophies

肌肉融合缺陷可能是人类营养不良的常见原因

• 批准号: nhmrc : 1065954
• 负责人: Prof Christophe Marcelle
• 金额: $ 26.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/muscle-fusion-defects-human-dystrophies/455212
• 关键词: Muscle; fusion; defects; may; common

While muscle fusion is a crucial step of muscle formation, it is surprising that human muscle diseases were never associated with muscle fusion defects. We have recently undertaken a genome-wide functional screen using a mouse muscle cell line. We identified 21 genes that were previously associated with muscle dystrophies in human. The aim of this project is to examine the role of those genes during muscle fusion in vivo, using the chick embryo, mouse mutants and lines from patients as models.

虽然肌肉融合是肌肉形成的关键步骤，但令人惊讶的是，人类肌肉疾病从未与肌肉融合缺陷相关。我们最近进行了一个全基因组功能筛选使用小鼠肌肉细胞系。我们鉴定了21个先前与人类肌肉营养不良相关的基因。本项目的目的是研究这些基因在体内肌肉融合过程中的作用，使用鸡胚，小鼠突变体和患者品系作为模型。