Seeing is believing: imaging muscle maintenance and repair

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We will characterise the behaviour of muscle stem cells in vivo within their micro-environment in normal and regenerating adult muscles, using high-end imaging technologies and mouse lines that we recently created. This will allow correlating cellular behaviours with the activation of signaling pathways, chosen for their likely role in the activation of satellite cells. We will then modulate the activity of these pathways in the satellite cell niche to evaluate their function.