PET Imaging of Cortical Dopamine Transmission in Cocaine Addiction
可卡因成瘾过程中皮质多巴胺传输的 PET 成像
基本信息
- 批准号:9193064
- 负责人:
- 金额:$ 56.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAddictive BehaviorAffinityAgeAgonistAmphetaminesAmygdaloid structureAnxietyAttentionAwardBindingBrainChronicChronic DiseaseClinical ResearchCocaineCocaine DependenceCognitionCognitive deficitsConflict (Psychology)Corpus striatum structureCorticotropin-Releasing HormoneDecision MakingDetectionDevelopmentDopamineDynorphinsFemaleFunctional ImagingFundingGenderHumanImageImpaired cognitionIntoxicationInvestigationKnowledgeLeadLigandsMeasurementMeasuresMediatingMemoryMidbrain structureMotorNegative ReinforcementsNeurocognitive DeficitNeuropeptidesNeurotransmittersNociceptionNoiseOpioid PeptideOralOutcome MeasurePathologicPeptide ReceptorPeptidesPharmaceutical PreparationsPhasePositive ReinforcementsPositron-Emission TomographyPreclinical Drug EvaluationPrefrontal CortexRacloprideRelapseRiskRodentRodent ModelRoleSamplingScanningShort-Term MemorySignal TransductionSmoking StatusStandardizationStressSystemTimeUp-RegulationUrineValidationVasopressinsVentral StriatumWithdrawaladdictioncocaine exposurecognitive functioncontingency managementcravingendogenous opioidsexperimental studyfollow-uphypocretinimaging studyin vivointerestneurochemistryneuropeptide Ynociceptinnovelpreferencepreventprocessing speedpublic health relevanceradiotracerreceptorrelapse predictionresponsetransmission process
项目摘要
DESCRIPTION (provided by applicant): Three different imaging groups have demonstrated a blunting in stimulant induced dopamine release at the level of the striatum in cocaine dependent subjects. An important limitation of these studies is the fact that measurements of D2/3 receptors and amphetamine-induced dopamine release were restricted mostly to the striatum because the ligands used did not provide enough signal to noise ratio to quantify D2/3 receptors in extrastriatal regions. Given that functional imaging studies in cocaine dependence suggests a relationship between pathological activation of the prefrontal cortex (PFC) and cognitive deficits it is of extreme interest to understand the regulatory role of dopamine in this particular region. During the previous cycle of this award we validated the use of the high affinity dopamine D2/3 radiotracer [11C]FLB 457 to measure amphetamine-induced dopamine release in the PFC. In aim 1 we propose to use this recently validated imaging paradigm in a clinical study in cocaine dependence to characterize amphetamine-induced dopamine release in the PFC, and relate it to cognitive deficits and relapse. We hypothesize that amphetamine-induced dopamine release will be decreased in the mesocortical dopaminergic system in cocaine abusers relative to healthy comparison subjects and be associated with cognitive impairments and less time to relapse. Recent basic investigations postulate that an imbalance between neurotransmitters that regulate stress and anti-stress underlie negative reinforcement and relapse in addiction. Nociceptin (N/OFQ) is one such peptide neurotransmitter that exerts anti-stress effects and prevents relapse in rodent models of addiction. No previous human studies have characterized N/OFQ in addiction. In aim 2, we propose to use [11C]NOP-1A PET to measure the in vivo status of nociceptive opioid peptide (NOP) receptors in cocaine abusers, and evaluate its relationship with stress, anxiety, craving, and relapse. This aim marks a cautious first step in a new direction for this renewal application, which we intend to follow up with further experiments in cocaine dependence as novel radiotracers become available to image other components of the brain stress (e.g., corticotrophin releasing hormone, orexin, vasopressin, etc.,) and anti-stress system (neuropeptide Y).
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RAJESH NARENDRAN其他文献
RAJESH NARENDRAN的其他文献
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{{ truncateString('RAJESH NARENDRAN', 18)}}的其他基金
PET Imaging of Cortical Dopamine Transmission in Cocaine Addiction
可卡因成瘾过程中皮质多巴胺传输的 PET 成像
- 批准号:
9722779 - 财政年份:2018
- 资助金额:
$ 56.17万 - 项目类别:
Imaging beta-amyloid in middle age alcoholics as a mechanism that increases their risk for Alzheimer’s disease
中年酗酒者中的β-淀粉样蛋白是一种增加其患阿尔茨海默病风险的机制
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9718353 - 财政年份:2016
- 资助金额:
$ 56.17万 - 项目类别:
In vivo imaging of corticotropin releasing factor-nociceptin receptor interactions
促肾上腺皮质激素释放因子-伤害感受肽受体相互作用的体内成像
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9198085 - 财政年份:2016
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$ 56.17万 - 项目类别:
PET Imaging of neurochemical transmission in cocaine use disorders
可卡因使用障碍中神经化学传递的 PET 成像
- 批准号:
10459233 - 财政年份:2009
- 资助金额:
$ 56.17万 - 项目类别:
PET Imaging of Cortical Dopamine Transmission in Cocaine Addiction
可卡因成瘾过程中皮质多巴胺传输的 PET 成像
- 批准号:
8118277 - 财政年份:2009
- 资助金额:
$ 56.17万 - 项目类别:
Imaging Cortical Dopamine Transmission in Alcohol Dependence
酒精依赖中皮质多巴胺传输的成像
- 批准号:
8132972 - 财政年份:2009
- 资助金额:
$ 56.17万 - 项目类别:
PET Imaging of Cortical Dopamine Transmission in Cocaine Addiction
可卡因成瘾过程中皮质多巴胺传输的 PET 成像
- 批准号:
7790857 - 财政年份:2009
- 资助金额:
$ 56.17万 - 项目类别:
PET Imaging of Cortical Dopamine Transmission in Cocaine Addiction
可卡因成瘾过程中皮质多巴胺传输的 PET 成像
- 批准号:
7934671 - 财政年份:2009
- 资助金额:
$ 56.17万 - 项目类别:
PET Imaging of Cortical Dopamine Transmission in Cocaine Addiction
可卡因成瘾过程中皮质多巴胺传输的 PET 成像
- 批准号:
9024494 - 财政年份:2009
- 资助金额:
$ 56.17万 - 项目类别:
In vivo measurement of dopamine transmission in schizophrenia
精神分裂症多巴胺传递的体内测量
- 批准号:
8372396 - 财政年份:2009
- 资助金额:
$ 56.17万 - 项目类别:
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