PAHs: New Technologies and Emerging Health Risks

PAH：新技术和新出现的健康风险

• 批准号: 9249048
• 负责人: Robyn L Tanguay
• 金额: $ 299.85万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9249048
• 关键词: Address; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biomedical Research; Biometry; Chemicals; Chemistry; Coal; Communities; Devices; Effectiveness; Environment; Environmental Health; Exposure to; Goals; Health; Human; Laboratories; Modeling; Oregon; Pacific Northwest; Petroleum; Physiological; Quality of life; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk; Risk Assessment; Sampling; Scientist; Site; Superfund; Time; Tobacco; Training; Translational Research; Universities; Work; Zebrafish; base; carcinogenicity; design; developmental toxicity; improved; innovation; instrumentation; multidisciplinary; new technology; next generation; pharmacokinetic model; programs; remediation; superfund site; training opportunity

The Oregon State University Superfund Research Program (SRP) is multi-investigator, multi-disciplinary and multi-institutional. In parnternship with Pacific Northwest National Laboratories, and other stakeholders and collaborators, we seek to develop new technologies to assess polycyclic aromatic hydrocarbons (PAHs) found at many of the nation's Superfund sites and assess the risk they pose for human health. The SRP consists of three biomedical research projects, two non-biomedical research projects, Administrative, Research Translation, Community Engagement, Training and two research support cores (Biostatistics and Modeling and Chemistry). Over the next five years of the program we will pursue a number of innovative and high impact research goals including: (1) the first ever study of how humans take-up and excrete carcinogenic PAHs at environmental levels of exposure; (2) produce Physiologically Based Pharmacokinetic (PBPK) models for risk assessment of PAH mixtures; (3) determine developmental toxicities of PAH mixtures and PAHs formed in the environment using a zebrafish model; (4) employ passive sampling devices to assess bioavailable PAHs at Superfund sites and the effectiveness of remediation strategies and; (5) employ new analytical approaches to assessing chemical changes in PAHs in soilds and sediments at Superfund sites over time. The cores will: (1) direct the activities of the SRP (Administrative); (2) pursue effective mechanisms for disseminating our findings to stakeholders (Research Translation), (3) work with communities impacted by PAH exposure to address concerns and pursue solutions for reduced risk (Community Engagement); (4) provide intensive multi-disciplinary training opportunities for the next generation of Environmental Health Scientists (Training) and; (5 and 6) provide Biostatistical and Modeling support for the design, conduct and interpretation of the research being conducted as well as using state-of-the- art Chemistry instrumentation and approaches to assess the identity and quantity of hundreds of PAHs found in environmental and biological matricies. Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities.

该俄勒冈州州立大学超级基金研究计划（SRP）是多调查员，多学科， 多机构。与太平洋西北国家实验室和其他利益攸关方建立伙伴关系， 合作伙伴，我们寻求开发新的技术来评估多环芳烃（PAH） 发现在许多国家的超级基金网站，并评估他们对人类健康构成的风险。的SRP 包括三个生物医学研究项目，两个非生物医学研究项目，行政， 研究翻译，社区参与，培训和两个研究支持核心（生物统计和 建模和化学）。在未来五年的计划中，我们将追求一些创新的 高影响力的研究目标包括：（1）首次研究人类如何吸收和排泄 致癌多环芳烃在环境暴露水平;（2）产生基于生理的药代动力学 （3）确定多环芳烃混合物的发育毒性 和多环芳烃在环境中形成的斑马鱼模型;（4）采用被动采样装置， 评估超级基金场地的生物可利用多环芳烃和补救策略的有效性;（5）采用 评估超级基金土壤和沉积物中多环芳烃化学变化的新分析方法 网站随着时间的推移。这些核心将：（1）指导战略调整方案的活动（行政）;（2）开展有效的 向利益相关者传播我们的研究结果的机制（研究翻译），（3）与 受PAH暴露影响的社区解决问题并寻求降低风险的解决方案 （4）为下一届政府提供密集的多学科培训机会， 培养环境健康科学家（培训）;（5和6）提供生物统计和建模 支持正在进行的研究的设计，实施和解释，以及使用国家的， 评估数百种多环芳烃的特性和数量的化学仪器和方法 在环境和生物基质中发现。实现这些目标将提供重要的科学 促进和改善受影响社区的生活质量。