Services to support the OBO foundry standards

项目摘要/摘要 开放生物医学本体论(OBO)铸造是一个社区组织的项目，旨在促进 本体的发现、发展、应用、协调、互操作和共享。OBO本体论 在与NIH相关的广泛领域中被广泛用作知识表示的标准 基础、翻译和临床研究任务。它们涵盖例如基因功能(基因本体论， GO)、疾病和表型(疾病本体论，DO；人类表型本体论，HP；Uberon解剖学 Ontology)、分析类型(Ontology for Biomedical Investigation，OBI)以及连接这些的关系 实体，包括本体内和本体之间(关系本体，RO)。十多年来，OBO一直在提供 向社区提供各种广泛使用的服务，包括1)OBO注册表，它收集标准化的 每个成员本体的元数据，例如域、范围、许可证、接触点等，从而增强 每个本体的可查找性，2)可配置的持久URL(URL)，其提供不变的地址 对于本体和本体类，增强了可访问性和重用性，3)OBO的可选内容托管 想要利用集中管理的版本控制的本体，4)标准化软件工具， 易于遵循本体开发的最佳实践，5)OBO原则、指南和最佳 旨在提高质量和互操作性的做法，以及6)外联和协调努力，以 在不同成员本体之间进行调解，以协调和减少重叠，通过 中央电子邮件列表和定期电话会议。本提案将提供有时间限制、有催化作用 支持通过升级现有服务所在的关键基础设施来提高现有服务的稳定性 基于，通过定义和应用元数据和PURL管理的标准，并通过应用最佳 来自软件工程的实践，以增加代码库的可维护性。第二，我们将推出新的 将自动化质量控制添加到我们的服务基础设施中(单独和在 集团)，加强我们的服务和标准化工具之间的集成，并增加监控和 指标。第三，我们会进行外展和培训工作，以提高社会人士的能力 参与OBO项目。为了实现这些目标，我们将继续保持我们的运营成本 极低的成本，并自由地共享我们构建的工具和资源。

PROJECT SUMMARY/ABSTRACT The Open Biomedical Ontologies (OBO) Foundry is a community organized project that aims to facilitate the discovery, development, application, harmonization, interoperability and sharing of ontologies. OBO ontologies are widely used as a standard for knowledge representation in a broad range of domains relevant to the NIH basic, translational, and clinical research mission. They cover for example gene functions (Gene Ontology, GO), diseases and phenotypes (Disease Ontology, DO; Human Phenotype Ontology, HP; Uberon Anatomy Ontology), assay types (Ontology for Biomedical Investigations, OBI), and relationships connecting these entities, both within and across ontologies (Relationship Ontology, RO). For over a decade, OBO has provided a variety of widely used services to the community, including 1) the OBO registry, which collects standardized metadata for each member ontology such as domain, scope, license, point of contact, etc., thus enhancing findability of each ontology, 2) configurable Persistent URLs (PURLs), which provide an unchanging address for ontologies and ontology classes, enhancing accessibility and reuse, 3) optional content hosting for OBO ontologies that want to take advantage of centrally managed versioning, 4) standardized software tools that make it easy to follow best practices for ontology development, 5) OBO principles, guidelines and best practices, designed to enhance quality and interoperability, and 6) an outreach and coordination effort to mediate between different member ontologies with the goal to coordinate and reduce overlap, through a central email list and regular teleconferences. The present proposal will provide time-limited, catalytic support to increase robustness of existing services by upgrading critical infrastructure on which they are based, by defining and applying standards for metadata and PURL management, and by applying best practices from software engineering to increase maintainability of the codebase. Second, we will introduce new capabilities into our service infrastructure to add automated quality controls to ontologies (individually and in groups), enhance the integration between our services and standardized tools, and add monitoring and metrics. Third, we will perform outreach and training efforts to increase the ability of the community to participate in the OBO project. In accomplishing these aims we will continue to keep our operating costs extremely low, and to freely share the tools and resources we build.