Gender and Developmental Trajectories to Adolescent Substance Use and Sexual Risk Behavior

青少年药物使用和性危险行为的性别和发展轨迹

• 批准号: 9380701
• 负责人: Meeyoung Oh Min
• 金额: $ 29.6万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9380701
• 关键词: Address; Adolescence; Adolescent; Age; Aggressive behavior; Alcohol or Other Drugs use; Behavior; Behavioral; Biological; Biological Process; Birth; Brain; Caregivers; Characteristics; Child; Child Abuse and Neglect; Child Care; Child Development; Childhood; Cocaine; Collaborations; Communities; Data; Data Collection; Data Set; Development; Disease; Drug Exposure; Drug abuse; Early identification; Environment; Equation; Etiology; Exposure to; Fetal Cocaine Exposure; Gender; General Population; Goals; Growth; Healthy People 2020; Heterogeneity; Individual; Language; Lead; Life; Life Style; Long-Term Effects; Matched Group; Minority; Modeling; Monitor; National Institute of Drug Abuse; Nature; Outcome; Pathway interactions; Population; Population Study; Prevention; Prevention program; Problem behavior; Reporting; Research; Risk; Risk Factors; Role; Site; Specific qualifier value; Statistical Models; Stress; Substance Use Disorder; System; Testing; Time; Trauma; Violence; Visit; Woman; adolescent substance use; attentional control; base; behavioral health intervention; behavioral outcome; boys; caregiving; cocaine exposure; cohort; comparative; elementary school; executive function; externalizing behavior; gender difference; girls; health disparity; high risk; high risk population; improved; inattention; low socioeconomic status; male; maltreatment; men; pediatrician; peer; prenatal; prenatal exposure; prevention service; response; screening; sex risk; sexual victimization; substance use prevention; tool

PROJECT SUMMARY/ABSTRACT This application proposes to conduct a secondary comparative analysis study to examine gender differences and similarities in the developmental trajectories of early behavioral problems and subsequent outcomes of substance use (SU) and sexual risk behaviors (SRBs) in adolescents with prenatal cocaine/poly drug exposure (PCE) vs. a matched group without PCE. Childhood behavioral problems (e.g., aggression, inattention) are well-established precursors to SU and SRBs. Although PCE has been associated with more behavioral problems, little is known about how PCE contributes to childhood developmental trajectories of behavioral problems, which may persist, desist, or escalate over time. Further, developmental trajectories of behavioral problems, SU, and SRBs may differ by gender, yet few studies have compared gender-specific childhood developmental trajectories that lead to SU and/or SRBs. The proposed study will harmonize data from two large, existing community-based birth cohorts (N=1,803): The Cleveland Prenatal Cocaine Exposure Study and the Maternal Lifestyle Study. The aims of the original studies examined long-term effects of in-utero exposure to cocaine on child development. In this proposal, we will examine heterogeneity in developmental trajectories, with specific foci on testing whether PCE and gender interactively contribute to specific trajectories along with the role(s) of life adversities (i.e., violence exposure, childhood maltreatment, sexual victimization), also key etiological factors in SU disorders and SRBs. Specific Aims are to: 1) Identify developmental trajectories of behavioral problems (externalizing, internalizing, inhibitory control/attention) and test for trajectory differences in gender, PCE, and environmental and biological correlates; 2) Examine associations between developmental trajectories of behavioral problems with SU and SRBs for boys and girls; and 3) Explore role(s) of life adversity (i.e., violence exposure, childhood maltreatment, sexual victimization) in trajectories leading to SU and SRBs separately for boys and girls. Caregiver-reported behavior from ages 2/3, 4/5, 6/7, 9, 10, 11, and 12/13 will be used to model trajectories using growth mixture modeling; generalized estimation equations will be used to model the effects of the behavioral trajectory class membership on SU and SRBs at ages 15 and 16/17, controlling for confounders such as parental attachment, monitoring and peer attachment. Findings from the proposed analyses will contribute to advanced early identification of those in greatest need of prevention services and specification of modifiable targets that may be gender-specific, promoting the ongoing development of gender-specific prevention programs, a promising way to address NIDA's strategic priorities in prevention of SU disorders. Further, given that children with PCE tend to be of minority and low socioeconomic status (SES), this study will contribute to reducing health disparities in behavioral health interventions observed in this population, one of the four overarching goals of Healthy People 2020.

项目总结/文摘