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PHASER – Pluridirectional High-energy Agile Scanning Electronic Radiotherapy

PHASER — 多向高能敏捷扫描电子放射治疗

基本信息

批准号：
9348329
负责人：
Vinod Bharadwaj
金额：
$ 22.47万
依托单位：
TIBARAY, INC.
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-03-17 至 2019-12-16
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9348329
关键词：
3-Dimensional Address Adverse effects Air Anatomy Animals Cause of Death Characteristics Clinical Collimator Complement Complex Conformal Radiotherapy Development Devices Diagnostic Diagnostic radiologic examination Dose Electrical Engineering Electron Beam Electrons Epidemic External Beam Radiation Therapy Extravasation Failure Feedback Freezing Frequencies Funding Generations Geometry Goals Human Image Intensity-Modulated Radiotherapy Laboratories Lead Legal patent Linear Accelerator Radiotherapy Systems Magnetism Maintenance Measures Mechanics Medical Methodology Minor Mission Modernization Motion Normal tissue morphology Organ Output Patients Performance Phase Photons Physics Physiological Plant Leaves Positioning Attribute Power Sources Production Radiation Radiation Oncology Radiation therapy Resolution Risk Roentgen Rays Scanning Scheme Shapes Source Speed System Techniques Technology Testing Therapeutic Time Translating Tumor Volume Universities X-Ray Computed Tomography attenuation base beamline cancer radiation therapy cancer therapy clinical translation commercialization cost cost effective cost effectiveness design engineering design imaging system improved innovation killings new technology next generation novel operation prototype treatment planning tumor

项目摘要

PROJECT SUMMARY/ABSTRACT The mission of TibaRay, Inc. is to develop and clinically translate next-generation radiation therapy technologies for the treatment of cancer, the single leading cause of death worldwide and increasing epidemically. A major advance in radiation therapy (RT) that has increased its curative potential and decreased side effects is the ability to sculpt radiation doses exquisitely in 3D to conform to tumors and spare surrounding normal organs. This dose sculpting is achieved by delivering radiation beams to the tumor from multiple directions, each of which has an optimized spatial intensity distribution. However, the fastest treatment times are still minutes long, limited by both beam intensities in electron linacs and the mechanical systems that are used to direct and shape the treatment beams. To address these major shortcomings of current state-of-the-art radiation delivery systems, TibaRay is proposing a radical new design for RT systems, Pluridirectional High-energy Agile Scanning Electronic Radiotherapy (PHASER), based on patented, novel technologies to produce intensity-modulated therapeutic energy x-ray beams from multiple directions using no mechanical systems to direct or shape the treatment beams. This is achieved by using an array of novel electron linacs each of which uses a magnetic electron beam scanning scheme paired with an extended bremsstrahlung target and multi-channel collimator array system referred to as Scanning Pencil-array-collimated High Speed Intensity-modulated X-ray source (SPHINX). The multiple linacs obviate the need to move a single linac on a gantry to achieve different beam directions and SPHINX eliminates the need for mechanical moving parts, e.g., multi-leaf collimators (MLCs), for therapy beam shaping. Each of the novel linacs used in PHASER are far more efficient and will generate more beam than conventional medical linacs. In the full PHASER design, it is estimated that the treatment time can be reduced to less than one second, effectively freezing physiological motion. The novel accelerator technology uses much simpler manufacturing techniques and production costs for PHASER are projected to be about the same as current state-of-the-art systems and maintenance/downtime costs should be lower. Initial proof of principle for the subsystems needed for PHASER have been demonstrated. TibaRay, in partnership with the Stanford University Department of Radiation Oncology and the SLAC National Acceleratory Laboratory, proposes to design (Phase I), build and test, and optimize a two-beam PHASER prototype (Phase II). In Phase III, TibaRay will develop the full PHASER prototype which will lead directly to commercialization and clinical translation. Our novel technology will help fill a tremendous worldwide need for high-quality, cost-effective radiation therapy for cancer.

项目概要/摘要 TibaRay, Inc. 的使命是开发下一代放射治疗技术并进行临床转化用于治疗癌症，这是世界范围内导致死亡的唯一主要原因，并且其流行趋势日益严重。放射治疗 (RT) 的一项重大进展是提高其治疗潜力并减少副作用能够以 3D 方式精确调整辐射剂量，以适应肿瘤并保护周围的正常器官。这种剂量控制是通过从多个方向向肿瘤传送辐射束来实现的，每个方向具有优化的空间强度分布。然而，最快的治疗时间仍然只有几分钟，有限通过电子直线加速器中的束强度和用于引导和成形的机械系统治疗光束。为了解决当前最先进的辐射传输系统的这些主要缺点，TibaRay 提出 RT系统的全新设计，多向高能敏捷扫描电子放射治疗 (PHASER)，基于获得专利的新技术，可产生强度调制的治疗能量 X 射线来自多个方向的光束，不使用机械系统来引导或塑造治疗光束。这是通过使用一系列新型电子直线加速器来实现，每个直线加速器都使用磁性电子束扫描该方案与扩展轫致辐射目标和多通道准直器阵列系统配对，称为扫描笔阵列准直高速强度调制 X 射线源 (SPHINX)。多个直线加速器无需在龙门架上移动单个直线加速器即可实现不同的光束方向，并且 SPHINX 消除了需要机械移动部件，例如用于治疗波束整形的多叶准直器 (MLC)。每个 PHASER 中使用的新型直线加速器比传统医疗设备效率更高，并且会产生更多光束直线加速器。在完整的PHASER设计中，预计治疗时间可以缩短到一秒以内，有效冻结生理运动。新颖的加速器技术使用更简单的制造 PHASER 的技术和生产成本预计与当前最先进的水平大致相同系统和维护/停机成本应该更低。 PHASER 所需子系统的初步原理证明已经得到证实。蒂巴雷，在与斯坦福大学放射肿瘤学系和 SLAC 国家加速器合作实验室，建议设计（第一阶段）、构建、测试和优化双光束 PHASER 原型（第一阶段）二）。在第三阶段，TibaRay 将开发完整的 PHASER 原型，这将直接导致商业化和临床翻译。我们的新技术将有助于满足全球对高质量、具有成本效益的放射治疗的巨大需求对于癌症。