University of North Carolina Womens Interagency HIV Study UNC WIHS

描述（由申请人提供）：本申请提议建立北卡罗来纳大学教堂山分校，作为妇女跨机构艾滋病毒研究（WIHS）的新地点。该提案代表了北卡罗来纳大学传染病中心、艾滋病研究中心、莱恩伯格综合癌症中心和塞西尔·g·谢普斯健康服务研究中心的研究人员之间的合作努力。我们建议迅速建立UNC-WIHS队列，为国家WIHS科学计划做出有意义的贡献，并开展一项雄心勃勃的艾滋病毒研究议程，包括社会流行病学和健康结果，先进的流行病学和生物统计方法，发病机制和癌症分子生物学。我们的目标是：1)招募并保留200名艾滋病毒阳性和100名艾滋病毒阴性妇女作为随访对象，她们是艾滋病毒感染的高风险人群，代表了北卡罗来纳州的艾滋病毒流行情况，从而将WIHS队列扩大到生活在美国艾滋病流行前沿地区的妇女；2)描述社会经济背景、获得医疗保险的变化和艾滋病毒+和艾滋病毒-妇女的健康结果之间的关系；3)利用UNC-WIHS和整个WIHS队列的数据开发和应用新的流行病学和统计方法；4)绝经前和绝经后妇女血液和生殖道中HIV持续存在的特征；5)研究乳腺癌和宫颈癌的病理生物学，以确定影响HIV阳性妇女癌症进展和治疗的免疫、微生物和遗传因素。通过提供多样化和互补性的妇女人口、创新的科学和强大的多学科研究骨干，UNC将加强WIHS的努力，扩大可以解决的问题范围，并与整个小组合作，改善艾滋病毒阳性妇女和艾滋病毒感染高风险妇女的健康。

DESCRIPTION (provided by applicant): This application proposes to establish The University of North Carolina at Chapel Hill as a new site for the Women's Interagency HIV Study (WIHS). The proposal represents a collaborative effort between investigators from The UNC Center for Infectious Diseases, Center for AIDS Research, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research. We propose to rapidly establish the UNC-WIHS cohort, contribute meaningfully to the national WIHS scientific program, and undertake an ambitious HIV research agenda that encompasses social epidemiology and health outcomes, advanced epidemiologic and biostatistical methods, pathogenesis, and molecular biology of cancer. We aim to: 1) Recruit and retain in follow-up a cohort of 200 HIV+ and 100 HIV- women who are at high risk for HIV infection and represent NC's HIV epidemic, thus expanding the WIHS Cohort to women who live in a region at the forefront of the US epidemic; 2) Characterize the relationship between socioeconomic context, changes in access to health insurance, and health outcomes among HIV+ and HIV- women; 3) Develop and apply novel epidemiologic and statistical methods using data from the UNC-WIHS and the entire WIHS cohort; 4) Characterize HIV persistence in the blood and genital tract among pre- and post-menopausal women; and 5) Investigate the pathobiology of breast and cervical cancers to identify immunological, microbial and genetic factors that affect cancer progression and treatment in HIV positive women. By contributing a diverse and complementary population of women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the WIHS, expand the range of questions that can be addressed and, in collaboration with the entire group, improve the health of HIV+ women and women at high risk for HIV infection.