ShEEP Request for Acquisition of Sable Promethion Caging

ShEEP 请求收购 Sable Promethion 笼具

• 批准号: 9213046
• 负责人: CATHERINE M KOTZ
• 金额: --
• 依托单位: MINNEAPOLIS VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9213046
• 关键词: Aging; Air; American; Animals; Area; Basic Science; Behavioral; Carbon Dioxide; Cardiovascular system; Cells; Cereals; Computer software; Control Groups; Data; Detection; Devices; Dimensions; Discipline; Doctor of Philosophy; Eating; Energy Metabolism; Environment; Equipment; Equipment and supply inventories; Event; Experimental Designs; Funding; Gases; Generations; Goals; Healthcare; Home environment; Housing; Humidity; Indirect Calorimetry; Information Systems; Intake; International; Investigational Therapies; Light; Malignant Neoplasms; Martes zibellina; Measurement; Measures; Medical; Memory; Metabolic; Minor; Modeling; Monitor; Movement; Mus; Neurosciences; Noise; Obesity; Operating System; Overweight; Physical activity; Positioning Attribute; Productivity; Program Evaluation; Rattus; Reading; Records; Reliability of Results; Reproducibility; Research; Research Design; Research Personnel; Resolution; Rodent; Running; Safety; Sampling; Secure; Services; Sleep; Solid; Stream; Stress; Surveys; System; Technology; Temperature; Testing; Translational Research; Veterans; Water consumption; Weight; abstracting; barometric pressure; base; computer program; data acquisition; equipment acquisition; gas analyzer; instrument; metabolic phenotype; metabolic rate; pressure; programs; research and development; seal; sensor; sound; stem cell therapy

Abstract: We are requesting funds through the Shared Equipment Evaluation Program (ShEEP) under the Research Equipment Management program offered by the Office of Research and Development for purchase of an 8 cage mouse and an 8 cage rat Promethion continuous cage metabolic phenotyping systems (Sable Systems, Las Vegas NV,USA) to expand upon our current Promethion mouse and rat systems. By utilizing continuous air-flow sampling, which allows for rapid metabolic measurements every second for all cages simultaneously, we are able to collect synchronous metabolic and behavioral (movement, food intake, water intake ,wheel running activity) measures. In addition, the new upgraded systems will allow for an Environmental Sensor Array to continuously monitor changes in each of the housing room's environment (temperature, noise, light, etc). The equipment will be housed within the Minneapolis VAHCS Research Services Veterinary Medical Unit. The additional systems will allow for the study of more animals simultaneously, making it possible to complete control and test paradigms more quickly, and reducing variability between control and test groups. This in turn will allow greater throughput of all users' experimental designs, increasing the productivity of the Minneapolis VAHCS investigators.The use of this equipment will compliment an existing inventory of multiuser based instruments with the end goal of increasing the efficiency of and supporting translational VA research. Dr. Catherine Kotz will oversee the administration and usage of the equipment under the full support of Minneapolis VAHCS Director, Mr. Patrick J. Kelly and the Research & Development Committee Chair, Dr. Ronald Bach. The major and minor user groups for this equipment span multiple VA research disciplines and represents both basic and translational research in areas such as: aging, cardiovascular, cancer, neuroscience, stem cell therapies and obesity. The VA funded users combined will be used at least 75% of the instrument capacity. The minor users group will occupy between 25%-30% of instrument capacity. The ability for Minneapolis VAHCS to continue to remain one of the largest and most active research programs in the VAHCS depends on the ability of its investigators to gain access to the newest generation of high-sensitivity, high-resolution instruments. The acquisition of the Promethion continuous cage metabolic phenotyping systems requested would accelerate and enhance the rate at which researchers from multiple disciplines could acquire, analyze, display, and understand data with the long-term goal of benefiting the unique health care needs of US Veterans. This not only benefits the progress of VAHCS research in general but it would benefit the health care of all Americans.

摘要：我们正在通过共享设备评估计划 (ShEEP) 申请资金 研究与发展办公室提供的研究设备管理计划供购买 8 笼小鼠和 8 笼大鼠 Promethion 连续笼代谢表型系统 (Sable Systems，拉斯维加斯内华达州，美国）扩展了我们当前的 Promethion 小鼠和大鼠系统。通过利用 连续气流采样，可以每秒对所有笼子进行快速代谢测量 同时，我们能够收集同步代谢和行为（运动、食物摄入、水 摄入量、车轮运行活动）措施。此外，新升级的系统将允许 环境传感器阵列持续监测每个房间环境的变化 （温度、噪音、光线等）。该设备将安置在明尼阿波利斯 VAHCS 研究中心内 服务兽医医疗单位。额外的系统将允许研究更多的动物 同时，可以更快地完成控制和测试范式，并减少 对照组和测试组之间的差异。这反过来又将为所有用户的实验提供更大的吞吐量 设计，提高明尼阿波利斯 VAHCS 调查人员的生产力。使用该设备将 补充现有的基于多用户的仪器库存，最终目标是提高效率 并支持转化 VA 研究。凯瑟琳·科茨 (Catherine Kotz) 博士将监督管理和使用 该设备得到了明尼阿波利斯 VAHCS 主任 Patrick J. Kelly 先生和研究与中心的全力支持 发展委员会主席罗纳德·巴赫博士。该设备的主要和次要用户组范围 多个 VA 研究学科，代表以下领域的基础研究和转化研究：老龄化、 心血管、癌症、神经科学、干细胞疗法和肥胖症。 VA 资助的用户合计将是 至少使用了仪器容量的 75%。未成年人用户群体将占据25%-30% 仪器容量。明尼阿波利斯 VAHCS 继续保持最大、最先进的地位之一的能力 VAHCS 中活跃的研究项目取决于其研究人员获取最新研究成果的能力 新一代高灵敏度、高分辨率仪器。收购 Promethion 连续笼 所要求的代谢表型系统将加速和提高研究人员的速度 多个学科可以获取、分析、显示和理解数据，以实现受益的长期目标 美国退伍军人独特的医疗保健需求。这不仅有利于VAHCS研究的进展 总体而言，但这将有利于所有美国人的医疗保健。