ShEEP Request for Acquisition of Sable Promethion Caging

翻译后摘要：我们要求通过共享设备评估计划（ShEEP）下的资金， 研究和开发办公室提供的研究设备管理计划，用于购买 8笼小鼠和8笼大鼠的Promethion连续笼代谢表型系统（Sable Systems，拉斯维加斯NV，USA），以扩展我们目前的Promethion小鼠和大鼠系统。通过利用 连续气流采样，允许每秒快速测量所有笼子的代谢 同时，我们能够收集同步代谢和行为（运动，食物摄入，水 进气量、车轮运行活动）测量。此外，新升级的系统将允许 环境传感器阵列可持续监测每个房间环境的变化 （温度、噪音、光线等）。该设备将被安置在明尼阿波利斯VAHCS研究中心内。 兽医服务单位。额外的系统将允许研究更多的动物 同时，使更快地完成控制和测试范例成为可能， 对照组和试验组之间的变异性。这反过来又将允许所有用户的实验 设计，提高了明尼阿波利斯VAHCS调查人员的生产力。该设备的使用将 补充现有的基于多用户的仪器清单，最终目标是提高效率 支持和支持翻译VA研究。凯瑟琳·科茨博士将监督管理和使用 在明尼阿波利斯VAHCS主任帕特里克J.凯利先生和研究与 发展委员会主席，罗纳德巴赫博士。此设备的主要用户组和次要用户组跨越 多个VA研究学科，并代表了基础和转化研究领域，如：老龄化， 心血管、癌症、神经科学、干细胞疗法和肥胖症。VA资助的用户组合将是 使用了至少75%的仪器容量。少数用户群体将占25%-30%， 仪器容量。明尼阿波利斯VAHCS继续保持最大和最大的能力之一， VAHCS的积极研究计划取决于其研究人员获得最新信息的能力 高灵敏度、高分辨率的仪器。Promethion连续笼的获得 所要求的代谢表型分析系统将加速和提高研究人员从 多个学科可以获取、分析、显示和理解数据，其长期目标是受益 美国退伍军人独特的医疗保健需求。这不仅有利于我国VAHCS研究的发展， 这是一个普遍的问题，但它将有利于所有美国人的医疗保健。

Abstract: We are requesting funds through the Shared Equipment Evaluation Program (ShEEP) under the Research Equipment Management program offered by the Office of Research and Development for purchase of an 8 cage mouse and an 8 cage rat Promethion continuous cage metabolic phenotyping systems (Sable Systems, Las Vegas NV,USA) to expand upon our current Promethion mouse and rat systems. By utilizing continuous air-flow sampling, which allows for rapid metabolic measurements every second for all cages simultaneously, we are able to collect synchronous metabolic and behavioral (movement, food intake, water intake ,wheel running activity) measures. In addition, the new upgraded systems will allow for an Environmental Sensor Array to continuously monitor changes in each of the housing room's environment (temperature, noise, light, etc). The equipment will be housed within the Minneapolis VAHCS Research Services Veterinary Medical Unit. The additional systems will allow for the study of more animals simultaneously, making it possible to complete control and test paradigms more quickly, and reducing variability between control and test groups. This in turn will allow greater throughput of all users' experimental designs, increasing the productivity of the Minneapolis VAHCS investigators.The use of this equipment will compliment an existing inventory of multiuser based instruments with the end goal of increasing the efficiency of and supporting translational VA research. Dr. Catherine Kotz will oversee the administration and usage of the equipment under the full support of Minneapolis VAHCS Director, Mr. Patrick J. Kelly and the Research & Development Committee Chair, Dr. Ronald Bach. The major and minor user groups for this equipment span multiple VA research disciplines and represents both basic and translational research in areas such as: aging, cardiovascular, cancer, neuroscience, stem cell therapies and obesity. The VA funded users combined will be used at least 75% of the instrument capacity. The minor users group will occupy between 25%-30% of instrument capacity. The ability for Minneapolis VAHCS to continue to remain one of the largest and most active research programs in the VAHCS depends on the ability of its investigators to gain access to the newest generation of high-sensitivity, high-resolution instruments. The acquisition of the Promethion continuous cage metabolic phenotyping systems requested would accelerate and enhance the rate at which researchers from multiple disciplines could acquire, analyze, display, and understand data with the long-term goal of benefiting the unique health care needs of US Veterans. This not only benefits the progress of VAHCS research in general but it would benefit the health care of all Americans.