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Neural dynamics of directly and indirectly conditioned placebo/nocebo effect

直接和间接调节的安慰剂/反安慰剂效应的神经动力学

基本信息

批准号：
9187423
负责人：
JIAN KONG
金额：
$ 21.75万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-12-01 至 2019-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9187423
关键词：
Affective Amygdaloid structure Anterior Anxiety Brain Brain region Clinical Cognitive Conscious Cues Empathy Goals Hippocampus (Brain)Inferior Insula of Reil Label Learning Life Light Limbic System Lobule Magnetoencephalography Medial Memory Methods Mind Names Pain Pain Disorder Pain intensity Parietal Parietal Lobe Pathway interactions Pattern Pharmaceutical Preparations Placebo Effect Placebos Post-Traumatic Stress Disorders Predisposition Prefrontal Cortex Questionnaires Research Resolution Response Latencies Retrieval Rewards Sensory Signal Transduction Somatosensory Cortex Source Subconscious Temporal Lobe Testing Time Visual Cortex addiction behavioral study cingulate cortex classical conditioning conditioning craving design experience experimental study improved millisecond mirror neuron neuromechanism optimism public health relevance relating to nervous system response social social learning theories trait

项目摘要

DESCRIPTION (provided by applicant): Placebo and nocebo have been intensively explored in direct conditioning/ context learning paradigms. However, most learning in daily life and clinical settings takes place indirectly (e.g., observational / social learning) in response to higly relevant contextual cues and may induce placebo/nocebo effects not only consciously but also subconsciously. Despite the ubiquity of indirect learning and the potential promise of harnessing it, little is known about the brain mechanisms of indirectly learned cue-induced placebo/nocebo. The goal of this proposal is to investigate the neural mechanism of direct and indirect, conscious and subliminal placebo/nocebo learning and retrieval. By applying MEG, featuring millisecond resolution, we will be able to study 1) placebo/nocebo responses evoked with conscious and non-conscious cues; 2) brain networks involved in context learning and placebo / nocebo effect; 3) the oscillatory dynamics underlying the interaction between direct / indirect learning and conscious / non- conscious activation of contextual cues. The use of pseudo drug names as cues will further enhance our understanding of the influence of medication labels on placebo/nocebo response. All subjects will undergo both a classical conditioning (experiencing different cues with different levels of pain intensity) and social observation conditioning (observing others' response to cues and pain). We will then compare subjective pain ratings and MEG signal changes evoked by identical pain preceded by high or low directly or observationally learned pseudo drug names, perceived consciously or non-consciously. The results obtained will shed light on developing new methods of harnessing placebo/nocebo effects, as well as understanding the mechanisms of direct and indirect learning in a clinical setting. Revealing the modulation effects of 'unseen' cues learned through social observation will unveil general mechanisms of non-conscious observational learning, which can be extended to other fields of psychiatric research such as addiction and Post-Traumatic Stress Disorder, where cue-activation of unwanted memories or cravings is relevant.