NK cell regulation of immune responses to dengue

NK 细胞调节登革热免疫反应

• 批准号: 9091417
• 负责人: ANUJA MATHEW
• 金额: $ 19.19万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-16 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9091417
• 关键词: Activated Natural Killer Cell; Address; Antibodies; Antigens; Antiviral Agents; Binding; CD8B1 gene; Cell Line; Cell physiology; Cells; Cessation of life; Chronic; Cytolysis; Cytomegalovirus; Data; Dengue; Dengue Infection; Dengue Virus; Disease; Disease model; Effector Cell; Epitopes; Family; Genotype; HIV; HLA-Bw4; Health; Hepatitis C virus; Human; Human Papillomavirus; Immune response; Individual; Killer Cells; Lead; Licensing; Ligands; MHC Class I Genes; Mediating; Mus; NK Cell Activation; NK cell receptor NKB1; Natural Killer Cells; Patients; Peptides; Peripheral Blood Mononuclear Cell; Phase; Play; Production; Proteins; Regulation; Research; Rest; Role; Severity of illness; Signal Transduction; T-Lymphocyte Epitopes; Validation; Viral Pathogenesis; Virus Diseases; Virus Replication; arm; base; cytokine; cytotoxicity; killer immunoglobulin-like receptor; member; prevent; receptor; research study; response; virus pathogenesis

 DESCRIPTION (provided by applicant): Natural Killer (NK) cells are primary effector cells of the innate immune response and play a critical role in the control of viral replication in several disease models. Depletions or deficiencies of NK cells lead to significantly more severe viral disease and death in both mice and humans. Killer immunoglobulin-like receptors (KIRs) interact with HLA class I ligands and play a central role in the regulation and activation of naturl killer (NK) cells. The interaction between KIRs and their HLA class I ligands can thus have a profound impact on the efficacy of NK cell-mediated control of viral pathogenesis and has been demonstrated for a number of chronic viral infections. Very little is known about the involvement of NK cells in regulating dengue virus infections. We have found that a CD8 T cell epitope on the non-structural protein 1 (NS1) of dengue interacts with a well characterized inhibitory receptor KIR3DL1 on NK cells. In this application, we will use the antigen-specific tetramers and peptides to dissect the interaction with KIR3DL1 and determine how dengue virus modulates the function of this important subset of NK cells. The studies outlined in this application will provide a better understanding of the importance of KIR-MHC class I interactions on NK cells and provide the rationale to target this innate arm of the immune response to control dengue virus replication.



项目成果

Regulation and Function of NK and T Cells During Dengue Virus Infection and Vaccination.

• DOI: 10.1007/978-981-10-8727-1_18
• 发表时间: 2018
• 期刊: Advances in experimental medicine and biology
• 作者: Mathew A

Defining the role of NK cells during dengue virus infection.

定义 NK 细胞在登革热病毒感染过程中的作用。

• DOI: 10.1111/imm.12928
• 发表时间: 2018
• 期刊: Immunology
• 影响因子: 6.4
• 作者: Mathew,Anuja