ShEEP Request for Intravascular Ultrasound System

ShEEP 请求血管内超声系统

基本信息

项目摘要

Abstract We are requesting “Intravascular Ultrasound System (IVUS)” for a group of VA investigators. IVUS has long been used in cardiology and other branches of physiological research for high- resolution intraluminal imaging. It is a unique approach for the evaluation of a wide range of abnormalities within the luminal structures throughout the body by generating tomographic section of the entire length of the luminal cavity. IVUS imaging has been able to obtain information not available with even the most sophisticated percutaneous sonography, CT, or MRI. The uniqueness of this approach has led to a variety of clinical applications. These miniature ultrasound transducer based catheters have played a role in the evaluation of the urinary and gastrointestinal tracts. Currently, a majority of cardiac imaging research techniques have mostly examined the heart using trans-thoracic imaging with ultrasound. We will outline three distinct areas of research where we have significant need for this equipment: 1) cardiology; 2) urology and 3) gastroenterology. Proposed IVUS use is expected to provide more detailed information to be extracted by imaging the heart using a series of tomographic section (from within the heart i.e., from apex to base using a ECG gated pullback) and reconstructing the three dimensional geometry to examine the remodeling of the myocardium during heart failure and during treatment. A single long axis image can be reconstructed using the software built in the IVUS system or many more sections can be created using custom software developed by our group. In addition, we propose to use this system for other important non- vascular intra-luminal investigations including in urethra and anal canal. Because sonographic catheters are smaller than 3mm (3.2 to 9F) in diameter (depending on the imaging frequency: range 9 to 45 MHz), they can be easily passed into the urethra (human and animal model) without the need for dilatation. In addition to thickness, this technique enables the therapeutic injections precisely at the region of the sphincter and to measure the exact depth of the injected material. Transurethral sonography has also been used to assess the deployment of intra- prostatic and intra-sphincter urethral stents. Intra-luminal sonography has been used for imaging urinary bladder neoplasms. Small tumors are clearly identified, and their degree of invasion can be evaluated. Currently, there are no good imaging modalities to assess tumor depth within the urinary bladder. Some urologists use magnetic resonance imaging (MRI) for staging of genitourinary diseases, including bladder cancer. Urologists have been accustomed to ultrasound and continue to use this imaging modality for prostate biopsies. Therefore, the use of transurethral ultrasonography for bladder cancer is more reasonable than any other imaging modality. Proposed equipment will be instrumental in determining the staging of the bladder tumor. In addition, IVUS can help assess the areas and depth of tissue to resect in order to achieve complete resection. This information is important in determining prognosis from bladder cancer, and for appropriate therapeutic interventions. Gastroenterological applications that were developed by Dr. Bhargava have been used for over a decade (see references in bio-sketch) but due to the obsolescence of the older machine a need for the new platform has become imperative. In summary, we anticipate that this equipment will be a significant addition to our research facility and will be jointly used by multiple investigators.
摘要 我们正在为一组VA研究者申请“血管内超声系统(IVUS)”。 IVUS长期以来一直用于心脏病学和生理学研究的其他分支, 分辨率腔内成像。这是一种独特的方法,用于评估各种各样的 通过生成断层扫描, 管腔的整个长度的截面。IVUS成像已经能够获得 即使是最复杂的经皮超声检查、CT也无法获得信息,或 核磁共振这种方法的独特性导致了各种临床应用。这些 基于微型超声换能器的导管在评估 泌尿道和胃肠道。目前,大多数心脏成像研究技术 大多数人都是通过超声波经胸成像来检查心脏的。我们将概述 三个不同的研究领域,我们有显着需要这种设备:1) 心脏病学; 2)泌尿学和3)胃肠病学。预计拟议的IVUS使用将提供更多 通过使用一系列断层摄影切片对心脏成像而提取的详细信息 (from在心脏内即,使用心电图门控回撤从顶点到底部)并重建 三维几何检查心脏过程中心肌重塑 失败和治疗期间。可以使用该软件重建单个长轴图像 内置在IVUS系统中,或者可以使用定制软件创建更多切片 由我们集团开发。此外,我们建议将该系统用于其他重要的非 血管腔内检查,包括尿道和肛管。因为超声波 导管直径小于3 mm(3.2至9 F)(取决于成像频率: 范围9至45 MHz),它们可以很容易地进入尿道(人类和动物模型) 而不需要扩张。除了厚度之外,这种技术还可以使治疗 精确地在括约肌区域注射,并测量注射的确切深度。 材料经尿道超声检查也被用于评估部署内, 前列腺和括约肌内尿道支架。腔内超声已用于 膀胱肿瘤的影像学检查。小肿瘤被清楚地识别,其程度 可以评估入侵。目前,没有很好的成像方式来评估肿瘤, 膀胱内的深度。一些泌尿科医生使用磁共振成像(MRI) 泌尿生殖系统疾病的分期,包括膀胱癌。泌尿科医生已经习惯了 并继续使用这种成像方式进行前列腺活检。因此使用 结论:经尿道超声检查诊断膀胱癌较其他影像学检查更为合理 模态。建议的设备将有助于确定膀胱分期 肿瘤此外,血管内超声可以帮助评估要切除的组织的区域和深度, 实现完全切除。这一信息是重要的,在确定预后从膀胱 癌症,并进行适当的治疗干预。胃肠病学应用, Bhargava博士开发的药物已经使用了十多年(见生物草图中的参考文献) 但由于旧机器的过时,对新平台的需求已经成为 势在必行总之,我们预计,这一设备将是一个重要的补充,我们的 研究设施,并将由多名研究人员共同使用。

项目成果

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MAHADEVAN Raj RAJASEKARAN其他文献

MAHADEVAN Raj RAJASEKARAN的其他文献

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{{ truncateString('MAHADEVAN Raj RAJASEKARAN', 18)}}的其他基金

Repeated Transurethral Interventions and Progressive Urethral Stricture Disease: Elucidation of Mechanisms and Novel Interventional Strategies
反复经尿道干预和进行性尿道狭窄疾病:机制阐明和新的干预策略
  • 批准号:
    10581375
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Feasibility Testing of Transpelvic Magnetic Stimulation as a Novel Intervention toImprove Urogenital Function in Prostate Cancer Survivors
经盆腔磁刺激作为改善前列腺癌幸存者泌尿生殖功能的新型干预措施的可行性测试
  • 批准号:
    10249223
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
ShEEP Request for Zeiss Axio Scan Z1 Digital Scanner
ShEEP 请求蔡司 Axio Scan Z1 数字扫描仪
  • 批准号:
    9905892
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Aging & Urethral Sphincter Dysfunction: Role of Wnt-B Catenin Signaling Pathways
老化
  • 批准号:
    10174741
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Targeting Wnt Signaling Pathways to Treat Age-Related Anal Incontinence
靶向 Wnt 信号通路治疗年龄相关性肛门失禁
  • 批准号:
    8825966
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Targeting Wnt Signaling Pathways to Treat Age-Related Anal Incontinence
靶向 Wnt 信号通路治疗年龄相关性肛门失禁
  • 批准号:
    8633331
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:

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