ShEEP Request for Intravascular Ultrasound System

ShEEP 请求血管内超声系统

• 批准号: 9212574
• 负责人: MAHADEVAN Raj RAJASEKARAN
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9212574
• 关键词: Affect; Aftercare; Aging; Anal canal; Anesthesiology; Animal Model; Animals; Anus; Archives; Area; Bladder; Bladder Neoplasm; Blood Vessels; Boston; Caliber; Cardiac; Cardiology; Catheters; Chest; Clinical; Computer software; Custom; Data; Devices; Dilatation - action; Electrocardiogram; Equipment; Evaluation; Excision; Fees; Frequencies; Gastroenterology; Gastrointestinal tract structure; Genital system; Geometry; Goals; Health; Healthcare; Heart; Heart failure; Human; Image; Image Analysis; Injection of therapeutic agent; Injury; Investigation; Length; Magnetic Resonance Imaging; Malignant neoplasm of urinary bladder; Measurement; Measures; Monitor; Motor; Muscle; Muscle function; Myocardial dysfunction; Myocardium; Physiological; Play; Population; Quality of life; Research; Research Personnel; Research Technics; Resected; Resolution; Role; Scientist; Series; Sphincter; Staging; Stents; Structure; System; Techniques; Therapeutic; Therapeutic Intervention; Thick; Time; Tissues; Training; Translational Research; Ultrasonic Transducer; Ultrasonography; Urethra; Urethral sphincter; Urinary tract; Urogenital Diseases; Urologist; Urology; Veterans; abstracting; age related; analog; base; cardiovascular visualization; clinical application; digital; disease diagnosis; experience; heart imaging; imaging modality; imaging system; improved; instrument; interest; medical specialties; novel; outcome forecast; prostate biopsy; research facility; software development; tissue regeneration; touchscreen; tumor

Abstract We are requesting “Intravascular Ultrasound System (IVUS)” for a group of VA investigators. IVUS has long been used in cardiology and other branches of physiological research for high- resolution intraluminal imaging. It is a unique approach for the evaluation of a wide range of abnormalities within the luminal structures throughout the body by generating tomographic section of the entire length of the luminal cavity. IVUS imaging has been able to obtain information not available with even the most sophisticated percutaneous sonography, CT, or MRI. The uniqueness of this approach has led to a variety of clinical applications. These miniature ultrasound transducer based catheters have played a role in the evaluation of the urinary and gastrointestinal tracts. Currently, a majority of cardiac imaging research techniques have mostly examined the heart using trans-thoracic imaging with ultrasound. We will outline three distinct areas of research where we have significant need for this equipment: 1) cardiology; 2) urology and 3) gastroenterology. Proposed IVUS use is expected to provide more detailed information to be extracted by imaging the heart using a series of tomographic section (from within the heart i.e., from apex to base using a ECG gated pullback) and reconstructing the three dimensional geometry to examine the remodeling of the myocardium during heart failure and during treatment. A single long axis image can be reconstructed using the software built in the IVUS system or many more sections can be created using custom software developed by our group. In addition, we propose to use this system for other important non- vascular intra-luminal investigations including in urethra and anal canal. Because sonographic catheters are smaller than 3mm (3.2 to 9F) in diameter (depending on the imaging frequency: range 9 to 45 MHz), they can be easily passed into the urethra (human and animal model) without the need for dilatation. In addition to thickness, this technique enables the therapeutic injections precisely at the region of the sphincter and to measure the exact depth of the injected material. Transurethral sonography has also been used to assess the deployment of intra- prostatic and intra-sphincter urethral stents. Intra-luminal sonography has been used for imaging urinary bladder neoplasms. Small tumors are clearly identified, and their degree of invasion can be evaluated. Currently, there are no good imaging modalities to assess tumor depth within the urinary bladder. Some urologists use magnetic resonance imaging (MRI) for staging of genitourinary diseases, including bladder cancer. Urologists have been accustomed to ultrasound and continue to use this imaging modality for prostate biopsies. Therefore, the use of transurethral ultrasonography for bladder cancer is more reasonable than any other imaging modality. Proposed equipment will be instrumental in determining the staging of the bladder tumor. In addition, IVUS can help assess the areas and depth of tissue to resect in order to achieve complete resection. This information is important in determining prognosis from bladder cancer, and for appropriate therapeutic interventions. Gastroenterological applications that were developed by Dr. Bhargava have been used for over a decade (see references in bio-sketch) but due to the obsolescence of the older machine a need for the new platform has become imperative. In summary, we anticipate that this equipment will be a significant addition to our research facility and will be jointly used by multiple investigators.

抽象的 我们要求一组VA研究人员要求“血管内超声系统（IVU）”。 长期以来，IVU一直在心脏病学和其他物理研究的分支中用于高级 分辨率内成像。这是评估广泛范围的独特方法 通过产生整个体内腔内结构内部异常 腔腔的整个长度的截面。 IVUS成像已经能够获得 甚至最复杂的经皮超声检查，CT或 MRI。这种方法的独特性导致了各种临床应用。这些 微型超声传感器的导管在评估中发挥了作用 尿和胃肠道。目前，大多数心脏成像研究技术 大多数使用超声检查的胸膜成像检查了心脏。我们将概述 我们非常需要该设备的三个不同研究领域：1） 心脏病学； 2）泌尿科和3）胃肠病学。提议的IVU的使用有望提供更多 详细信息可以通过使用一系列层析成像来对心脏进行成像提取 （从心脏内部，从顶点到基础，使用ECG门控回撤回）然后重建 三维的几何形状检查心脏时心肌的重塑 失败和治疗期间。可以使用软件重建单个长轴图像 在IVUS系统中构建或可以使用自定义软件创建更多部分 由我们的小组开发。此外，我们建议将该系统用于其他重要的非 - 血管内研究，包括尿道和肛管。因为超声 导管的直径小于3mm（3.2至9F）（取决于成像频率： 范围9至45 MHz），可以轻松地进入尿道（人类和动物模型） 无需扩张。除厚度外，该技术还可以治疗 精确注射括约肌区域，并测量注射的精确深度 材料。经尿道超声检查也已用于评估内部的部署 前列腺和晶状尿道支架。腹腔内超声处理已用于 成像泌尿膀胱肿瘤。清楚地鉴定出小肿瘤，其学位 可以评估入侵。目前，没有良好的成像方式来评估肿瘤 膀胱内的深度。一些泌尿科医生使用磁共振成像（MRI） 包括膀胱癌在内的生殖疾病的分期。泌尿科医生习惯了 超声波并继续将这种成像方式用于前列腺活检。因此，使用 膀胱癌的尿道超声检查比任何其他成像更合理 方式。拟议的设备将有助于确定膀胱的分期 瘤。此外，IVU可以帮助评估组织的区域和深度，以便为了 实现完整的切除。此信息对于确定膀胱预后很重要 癌症，并进行适当的治疗干预措施。胃肠病学应用 由Bhargava博士开发的已有十多年了（请参阅《生物 - 熟与者》中的参考文献） 但是，由于旧机器的过时，对新平台的需求已成为 至关重要的。总而言之，我们预计该设备将是我们的重要补充 研究机构将由多个研究人员共同使用。