ShEEP Request for Intravascular Ultrasound System

ShEEP 请求血管内超声系统

基本信息

项目摘要

Abstract We are requesting “Intravascular Ultrasound System (IVUS)” for a group of VA investigators. IVUS has long been used in cardiology and other branches of physiological research for high- resolution intraluminal imaging. It is a unique approach for the evaluation of a wide range of abnormalities within the luminal structures throughout the body by generating tomographic section of the entire length of the luminal cavity. IVUS imaging has been able to obtain information not available with even the most sophisticated percutaneous sonography, CT, or MRI. The uniqueness of this approach has led to a variety of clinical applications. These miniature ultrasound transducer based catheters have played a role in the evaluation of the urinary and gastrointestinal tracts. Currently, a majority of cardiac imaging research techniques have mostly examined the heart using trans-thoracic imaging with ultrasound. We will outline three distinct areas of research where we have significant need for this equipment: 1) cardiology; 2) urology and 3) gastroenterology. Proposed IVUS use is expected to provide more detailed information to be extracted by imaging the heart using a series of tomographic section (from within the heart i.e., from apex to base using a ECG gated pullback) and reconstructing the three dimensional geometry to examine the remodeling of the myocardium during heart failure and during treatment. A single long axis image can be reconstructed using the software built in the IVUS system or many more sections can be created using custom software developed by our group. In addition, we propose to use this system for other important non- vascular intra-luminal investigations including in urethra and anal canal. Because sonographic catheters are smaller than 3mm (3.2 to 9F) in diameter (depending on the imaging frequency: range 9 to 45 MHz), they can be easily passed into the urethra (human and animal model) without the need for dilatation. In addition to thickness, this technique enables the therapeutic injections precisely at the region of the sphincter and to measure the exact depth of the injected material. Transurethral sonography has also been used to assess the deployment of intra- prostatic and intra-sphincter urethral stents. Intra-luminal sonography has been used for imaging urinary bladder neoplasms. Small tumors are clearly identified, and their degree of invasion can be evaluated. Currently, there are no good imaging modalities to assess tumor depth within the urinary bladder. Some urologists use magnetic resonance imaging (MRI) for staging of genitourinary diseases, including bladder cancer. Urologists have been accustomed to ultrasound and continue to use this imaging modality for prostate biopsies. Therefore, the use of transurethral ultrasonography for bladder cancer is more reasonable than any other imaging modality. Proposed equipment will be instrumental in determining the staging of the bladder tumor. In addition, IVUS can help assess the areas and depth of tissue to resect in order to achieve complete resection. This information is important in determining prognosis from bladder cancer, and for appropriate therapeutic interventions. Gastroenterological applications that were developed by Dr. Bhargava have been used for over a decade (see references in bio-sketch) but due to the obsolescence of the older machine a need for the new platform has become imperative. In summary, we anticipate that this equipment will be a significant addition to our research facility and will be jointly used by multiple investigators.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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MAHADEVAN Raj RAJASEKARAN其他文献

MAHADEVAN Raj RAJASEKARAN的其他文献

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{{ truncateString('MAHADEVAN Raj RAJASEKARAN', 18)}}的其他基金

Repeated Transurethral Interventions and Progressive Urethral Stricture Disease: Elucidation of Mechanisms and Novel Interventional Strategies
反复经尿道干预和进行性尿道狭窄疾病:机制阐明和新的干预策略
  • 批准号:
    10581375
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
Feasibility Testing of Transpelvic Magnetic Stimulation as a Novel Intervention toImprove Urogenital Function in Prostate Cancer Survivors
经盆腔磁刺激作为改善前列腺癌幸存者泌尿生殖功能的新型干预措施的可行性测试
  • 批准号:
    10249223
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
ShEEP Request for Zeiss Axio Scan Z1 Digital Scanner
ShEEP 请求蔡司 Axio Scan Z1 数字扫描仪
  • 批准号:
    9905892
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
Aging & Urethral Sphincter Dysfunction: Role of Wnt-B Catenin Signaling Pathways
老化
  • 批准号:
    10174741
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
Targeting Wnt Signaling Pathways to Treat Age-Related Anal Incontinence
靶向 Wnt 信号通路治疗年龄相关性肛门失禁
  • 批准号:
    8825966
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Targeting Wnt Signaling Pathways to Treat Age-Related Anal Incontinence
靶向 Wnt 信号通路治疗年龄相关性肛门失禁
  • 批准号:
    8633331
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:

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