Puberty, neural systems for social processes, and early adolescent mental health: A longitudinal neuroimaging study

青春期、社会过程的神经系统和青少年早期心理健康：一项纵向神经影像学研究

• 批准号: 9111061
• 负责人: Jennifer Hope Pfeifer
• 金额: $ 56.58万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9111061
• 关键词: Adolescence; Adolescent; Adrenal hormone preparation; Age; Anxiety; Behavior; Behavioral; Biological; Brain; Child; Childhood; Cognitive; Complex; Data; Data Analyses; Data Collection; Databases; Development; Developmental Process; Diffusion Magnetic Resonance Imaging; Early Diagnosis; Early Intervention; Female Adolescents; Goals; Gonadal Hormones; Health; Hormonal; Hormones; Incidence; Individual; Intervention; Investigation; Knowledge; Life; Link; Longevity; Measures; Mediating; Mediation; Mediator of activation protein; Mental Depression; Mental Health; Mental disorders; Modeling; Motivation; Neurobiology; Pattern; Phase; Prevention; Prevention strategy; Preventive Intervention; Process; Psychopathology; Puberty; Research; Research Domain Criteria; Rest; Risk; Risk Factors; Sampling; Self Disclosure; Self Perception; Self-Examination; Self-Injurious Behavior; Services; Sex Characteristics; Social Behavior; Social Environment; Social Processes; Staging; Statistical Models; Structure; Symptoms; Syndrome; System; Techniques; Testing; Time; Translating; base; depressive symptoms; developmental plasticity; early adolescence; emotional disclosure; high risk; indexing; mental state; model building; neural circuit; neurobiological mechanism; neuroimaging; novel; programs; prospective; psychologic; relating to nervous system; social; social cognition; treatment program

 DESCRIPTION (provided by applicant): Adolescence is a period of dramatic developmental transitions - from puberty-related changes in hormones, bodies, and brains to a complex psychological reorientation to the social world. The concurrent and marked increase in the onset of many psychiatric syndromes has prompted the search for key developmental processes that drive changes in risk for psychopathology during this period of life. Pubertal development is a prime candidate, but the precise neurobiological mechanisms via which puberty impacts adolescent-emergent mental health problems are still unknown. Hormonal surges associated with pubertal development in early adolescence are believed to impact a range of factors associated with brain development, psychological motivations, and social behavior that have demonstrated associations with risk for mental health symptoms. Therefore, this complex transition spanning molecules, neural circuits, and behavior is particularly well-suited for investigation using the RDoC mechanism. The proposed research focuses on constructs from the RDoC domain of Systems for Social Processes that change rapidly during adolescence: Self-Knowledge, Understanding of Mental States, and Affiliation. We hypothesize that these social processes (and their underlying neural circuitry) mediate the known relationship between the biological cascade of development associated with puberty and adolescent-emergent mental health problems. Accordingly, this proposal aims to conduct a comprehensive multilevel investigation of the connections between social cognitive and biological changes during early adolescence, in order to reveal the ways in which these interconnected changes relate to risk for the emergence of a range of mental health problems that are known to be associated with pubertal development (i.e., symptoms of depression, anxiety, and deliberate self-harm). Specifically, we will accomplish this goal by conducting a prospective longitudinal neuroimaging study of adolescent girls including three waves of data collection separated by 18 months (initial N=170, age 11 ± 1 years). At each time point we will assess: i) levels of adrenal and gonadal hormones associated with pubertal development, as well as anthropometric data and secondary sex characteristics; ii) brain structure, anatomical connectivity (diffusion tensor imaging), and resting-state functional connectivity; iii) social cognitive brain functioning and behavior (in two paradigms measuring self-evaluation, perspective-taking, and intrinsic value of self-disclosure); and iv) mental health symptoms (particularly of depression, anxiety, and deliberate self-harm). We will use advanced statistical modeling techniques to describe the cross-sectional and longitudinal relationships between developmental patterns in each of these domains. The project will therefore inform a mechanistic model of the association between developmental and psychopathological processes during this stage of life, one that will critically inform early intervention and prevention strategies.

 描述(申请人提供)：青春期是一个戏剧性的发展过渡时期-从与青春期有关的荷尔蒙、身体和大脑的变化，到复杂的心理重新定位到社交世界。同时，许多精神综合征的发病显著增加，促使人们寻找关键的发育过程，这些过程推动了这一生命阶段精神病理学风险的变化。青春期发育是一个主要的候选因素，但青春期影响青少年突发心理健康问题的确切神经生物学机制仍不清楚。与青春期早期发育相关的荷尔蒙激增被认为会影响与大脑发育、心理动机和社会行为相关的一系列因素，这些因素已证明与心理健康症状的风险有关。因此，这种跨越分子、神经回路和行为的复杂转变特别适合于使用RDoC机制进行研究。这项拟议的研究集中在RDoC领域的社会过程系统在青春期迅速变化的结构：自我认识、对心理状态的理解和从属关系。我们假设，这些社会过程(及其潜在的神经回路)调解了与青春期相关的生物发育级联和青少年突发心理健康问题之间的已知关系。因此，这项提议旨在对青春期早期社会认知和生物变化之间的联系进行全面的多层次调查，以揭示这些相互关联的变化与出现一系列已知与青春期发育有关的心理健康问题(即抑郁、焦虑和故意自残的症状)的风险的方式。具体地说，我们将通过对青春期女孩进行前瞻性的纵向神经成像研究来实现这一目标，包括三波相隔18个月的数据收集(初始N=170，年龄11±1岁)。在每个时间点，我们将评估：i)与青春期发育有关的肾上腺和性腺激素水平，以及人体测量数据和第二性征；ii)大脑结构、解剖连通性(扩散张量成像)和静息状态功能连通性；iii)社会认知脑功能和行为 衡量自我评价、采取观点和自我表露的内在价值的范式)；和iv)精神健康症状(特别是抑郁、焦虑和故意的自我伤害)。我们将使用先进的统计建模技术来描述这些领域中每个领域的发展模式之间的横向和纵向关系。因此，该项目将提供一个机制模型，说明在生命的这个阶段，发育过程和精神病理过程之间的联系，这将关键地为早期干预和预防战略提供信息。