A prospective longitudinal study of transactional associations between social, neural, and hormonal changes and adolescent girls' mental health trajectories

一项关于社会、神经和荷尔蒙变化与青春期女孩心理健康轨迹之间交互关联的前瞻性纵向研究

• 批准号: 10453386
• 负责人: Jennifer Hope Pfeifer
• 金额: $ 71.84万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-12 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10453386
• 关键词: Address; Adolescence; Adolescent; Affect; Age; Aggressive behavior; Anxiety; Area; Behavior; Behavioral; Biological; Biological Assay; Biological Factors; Biological Markers; Biological Process; Biology; Brain; Buffers; Clinical; Communities; Conflict (Psychology); Data; Data Sources; Development; Diagnosis; Diagnostic; Disease; Early Intervention; Enrollment; Feeling; Female Adolescents; Fostering; Frequencies; Friendships; Funding; Future; Gonadal Steroid Hormones; Hormonal; Hormonal Change; Hormones; Individual; Intervention; Interview; Investigation; Knowledge; Laboratories; Longevity; Longitudinal Studies; Longitudinal prospective study; Measures; Medial; Mediating; Mental Depression; Mental Health; Mental disorders; Modality; Motion; National Institute of Mental Health; Nature; Patient Self-Report; Personal Satisfaction; Phase Transition; Phenotype; Play; Prefrontal Cortex; Prevention; Prevention approach; Process; Puberty; Public Health; Questionnaires; Recording of previous events; Recurrence; Research; Risk; Risk Marker; Role; Sampling; Self Disclosure; Self Perception; Self-Injurious Behavior; Series; Severities; Sexual Maturation; Social Change; Social Development; Social Functioning; Social Processes; Societal Factors; Stressful Event; Structure; Symptoms; Time; Ventral Striatum; Visit; biomarker identification; biopsychosocial; cohort; data acquisition; design; diaries; dynamic system; early adolescence; experience; girls; improved; innovation; insight; interest; intimate behavior; knowledge translation; lens; multimodality; neurodevelopment; novel; peer; personalized intervention; prospective; psychosocial; pubertal timing; racism; relating to nervous system; resilience; rumination; social; social cognition; socioeconomic disparity; stress management; translational neuroscience

ABSTRACT Internalizing problems are common, harmful, and sharply increasing amongst adolescent girls – creating a public health imperative to identify mechanisms as well as markers of risk or resilience, spanning from biology to behavior. It is also essential to identify for whom these issues will be adolescent-limited versus indicative of persistent or worsening mental health, and understand the reasons why. Core biological and social processes of adolescence, such as puberty, brain development, and peer relationships, are promising targets. Socially, building and strengthening close friendships and romantic relationships are central developmental tasks in mid-to-late adolescence. The quality of close peer relationships in mid-to-late adolescent girls is known to have bidirectional and nuanced associations with emergence and recurrence of depression, anxiety, and self-harm. Interrogating this dual nature of close relationships, across timescales from days to years, is critical to begin addressing the emerging mental health crisis in adolescent girls. Furthermore, it is necessary to also account for the extended influence of pubertal processes, as puberty itself is strongly implicated in adolescent girls’ mental health. Ongoing maturation of sex hormones as well as brain structure, function, and connectivity through late adolescence makes it vital to integrate the contribution of developmental change in these biological factors to social processes and internalizing problems. The Transitions in Adolescent Girls (TAG) study, launched in 2015 (R01/R56 MH107418), was designed as a comprehensive multilevel investigation of the connections between biological and social changes during early-to-mid adolescence, as mechanisms of risk for the emergence of depression, anxiety, and self-harm. We enrolled a community sample of N=174 girls (initial ages 10-13 years) into a longitudinal study, with three waves of data collected every 18 months, including two laboratory visits at each wave. The first phase of the TAG study focused on early-to-mid adolescent mental health, as shaped by pubertal, neural, and social development (self-perception and social cognition). We propose to collect three additional waves of data, approximately 18 months apart, extending the cohort’s age range to 21 years. This new phase of the TAG study will have a developmentally-appropriate multilevel emphasis on close peer relationships, assessed via established questionnaires, daily self-reports, and novel paradigms that tap into intimate self-disclosure behavior and brain function. It will conduct innovative analyses to relate daily positive and negative experiences in close friendships and romantic relationships, with changes in well-being. Finally, it will continue to deeply phenotype ongoing biological (neural, hormonal, and pubertal) changes, and relate these to antecedent and subsequent social processes and mental health. We propose that close relationship quality and neurodevelopment during mid-to-late adolescence is not only predictive of concurrent and near-future mental health, but also part of a cascading series of developmental and risk processes that are set into motion by earlier biological and psychosocial changes.

摘要 内化问题在青春期女孩中很常见，危害很大，而且急剧增加。 创建一项公共卫生任务，以确定风险或复原力的机制和标志，跨越 从生物学到行为学。同样重要的是，确定这些问题针对的是哪些青少年，而不是 表明精神健康状况持续或恶化，并了解其原因。核心生物和 青春期的社会过程，如青春期、大脑发育和同伴关系，是有希望的 目标。在社会上，建立和加强亲密的友谊和浪漫关系是核心 青春期中后期的发展任务。中后期亲密同伴关系的质量 众所周知，青春期女孩与新发和复发有双向和微妙的联系。 抑郁、焦虑和自我伤害。询问这种亲密关系的双重性质，跨越时间尺度，从 从日复一日到年复一年，这对于开始解决青春期女孩中新出现的心理健康危机至关重要。此外， 也有必要解释青春期过程的广泛影响，因为青春期本身是强烈的 与青春期女孩的心理健康有关。性激素和大脑结构的持续成熟， 通过青春期后期的功能和连接性，整合发展的贡献是至关重要的 这些生物因素的变化对社会进程和内在化问题的影响。青春期的转变 女孩(TAG)研究于2015年启动(R01/R56 MH107418)，旨在作为一个全面的多层次 青春期早期至中期生物学变化和社会变化之间关系的调查 抑郁、焦虑和自我伤害出现的风险机制。我们登记了一个社区样本 N=174名女孩(初始年龄10-13岁)进入一项纵向研究，每18岁收集三波数据 几个月，包括每波两次实验室访问。TAG研究的第一阶段侧重于早期到中期 青少年心理健康，由青春期、神经和社会性发展(自我感知和社会性)塑造 认知)。我们建议额外收集三波数据，大约相隔18个月，延长 队列的年龄范围从21岁到21岁。TAG研究的这一新阶段将具有适合发展的 多层次强调密切的同伴关系，通过既定的问卷、每日自我报告、 以及新的范例，利用亲密的自我表露行为和大脑功能。它将进行创新 分析了亲密友谊和浪漫关系中的日常积极和消极经历，以及 幸福感的变化。最后，它将继续深入地表现正在进行的生物(神经、激素和 青春期)的变化，并将这些与之前和随后的社会过程和心理健康联系起来。我们 提出亲密关系质量和青春期中后期的神经发育不仅是 预测当前和近期的心理健康，但也是一系列级联发展的一部分 以及由早期的生物和心理社会变化启动的风险过程。