A prospective longitudinal study of transactional associations between social, neural, and hormonal changes and adolescent girls' mental health trajectories

一项关于社会、神经和荷尔蒙变化与青春期女孩心理健康轨迹之间交互关联的前瞻性纵向研究

• 批准号: 10453386
• 负责人: Jennifer Hope Pfeifer
• 金额: $ 71.84万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-12 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10453386
• 关键词: Address; Adolescence; Adolescent; Affect; Age; Aggressive behavior; Anxiety; Area; Behavior; Behavioral; Biological; Biological Assay; Biological Factors; Biological Markers; Biological Process; Biology; Brain; Buffers; Clinical; Communities; Conflict (Psychology); Data; Data Sources; Development; Diagnosis; Diagnostic; Disease; Early Intervention; Enrollment; Feeling; Female Adolescents; Fostering; Frequencies; Friendships; Funding; Future; Gonadal Steroid Hormones; Hormonal; Hormonal Change; Hormones; Individual; Intervention; Interview; Investigation; Knowledge; Laboratories; Longevity; Longitudinal Studies; Longitudinal prospective study; Measures; Medial; Mediating; Mental Depression; Mental Health; Mental disorders; Modality; Motion; National Institute of Mental Health; Nature; Patient Self-Report; Personal Satisfaction; Phase Transition; Phenotype; Play; Prefrontal Cortex; Prevention; Prevention approach; Process; Puberty; Public Health; Questionnaires; Recording of previous events; Recurrence; Research; Risk; Risk Marker; Role; Sampling; Self Disclosure; Self Perception; Self-Injurious Behavior; Series; Severities; Sexual Maturation; Social Change; Social Development; Social Functioning; Social Processes; Societal Factors; Stressful Event; Structure; Symptoms; Time; Ventral Striatum; Visit; biomarker identification; biopsychosocial; cohort; data acquisition; design; diaries; dynamic system; early adolescence; experience; girls; improved; innovation; insight; interest; intimate behavior; knowledge translation; lens; multimodality; neurodevelopment; novel; peer; personalized intervention; prospective; psychosocial; pubertal timing; racism; relating to nervous system; resilience; rumination; social; social cognition; socioeconomic disparity; stress management; translational neuroscience

ABSTRACT Internalizing problems are common, harmful, and sharply increasing amongst adolescent girls – creating a public health imperative to identify mechanisms as well as markers of risk or resilience, spanning from biology to behavior. It is also essential to identify for whom these issues will be adolescent-limited versus indicative of persistent or worsening mental health, and understand the reasons why. Core biological and social processes of adolescence, such as puberty, brain development, and peer relationships, are promising targets. Socially, building and strengthening close friendships and romantic relationships are central developmental tasks in mid-to-late adolescence. The quality of close peer relationships in mid-to-late adolescent girls is known to have bidirectional and nuanced associations with emergence and recurrence of depression, anxiety, and self-harm. Interrogating this dual nature of close relationships, across timescales from days to years, is critical to begin addressing the emerging mental health crisis in adolescent girls. Furthermore, it is necessary to also account for the extended influence of pubertal processes, as puberty itself is strongly implicated in adolescent girls’ mental health. Ongoing maturation of sex hormones as well as brain structure, function, and connectivity through late adolescence makes it vital to integrate the contribution of developmental change in these biological factors to social processes and internalizing problems. The Transitions in Adolescent Girls (TAG) study, launched in 2015 (R01/R56 MH107418), was designed as a comprehensive multilevel investigation of the connections between biological and social changes during early-to-mid adolescence, as mechanisms of risk for the emergence of depression, anxiety, and self-harm. We enrolled a community sample of N=174 girls (initial ages 10-13 years) into a longitudinal study, with three waves of data collected every 18 months, including two laboratory visits at each wave. The first phase of the TAG study focused on early-to-mid adolescent mental health, as shaped by pubertal, neural, and social development (self-perception and social cognition). We propose to collect three additional waves of data, approximately 18 months apart, extending the cohort’s age range to 21 years. This new phase of the TAG study will have a developmentally-appropriate multilevel emphasis on close peer relationships, assessed via established questionnaires, daily self-reports, and novel paradigms that tap into intimate self-disclosure behavior and brain function. It will conduct innovative analyses to relate daily positive and negative experiences in close friendships and romantic relationships, with changes in well-being. Finally, it will continue to deeply phenotype ongoing biological (neural, hormonal, and pubertal) changes, and relate these to antecedent and subsequent social processes and mental health. We propose that close relationship quality and neurodevelopment during mid-to-late adolescence is not only predictive of concurrent and near-future mental health, but also part of a cascading series of developmental and risk processes that are set into motion by earlier biological and psychosocial changes.

抽象的 在青春期女孩中，间隔问题是普遍，有害和急剧增加的 - 创建公共卫生必须确定机制以及风险或弹性标记，跨越 从生物学到行为。确定这些问题将是青少年有限与 指示持续或担心心理健康，并了解原因。核心生物学和 青少年的社会过程，例如青春期，大脑发展和同伴关系，有希望 目标。在社交上，建立和加强亲密的朋友和浪漫的关系是中心 中部青少年的发展任务。中及中期亲密关系的质量 众所周知，青春期女孩与出现和复发的双向和细微差别的关联 抑郁，焦虑和自我伤害。询问跨时标的亲密关系的这种双重性质 几天到几年，开始解决青春期女孩的新兴心理健康危机至关重要。此外， 有必要考虑青春期过程的扩展影响，因为青春期本身很强 在青春期女孩的心理健康中实施。性激素和大脑结构的持续成熟， 功能和通过青少年晚期的连通性使整合发展的贡献至关重要 这些生物学因素将社会过程和内部化问题变化。青少年的过渡 Girls（Tag）研究于2015年推出（R01/R56 MH107418），被设计为综合的多级 研究早期至中心期间生物学变化与社会变化之间的联系，作为 抑郁症，动画和自我伤害的风险机制。我们注册了社区样本 n = 174个女孩（最初年龄10-13岁）进行了一项纵向研究，每18次收集三个数据波 几个月，包括两个实验室在每个浪潮中访问。标签研究的第一阶段集中于早到中 青春期的心理健康，由青春期，神经和社会发展（自我感知与社会）塑造 认识）。我们建议收集三个额外的数据浪潮，相距约18个月，以扩展 队列的年龄范围为21岁。标签研究的新阶段将具有适当的开发 多层次强调密切的同伴关系，通过既定的问卷，每日自我报告评估， 和新的范式，这些范式利用了私密的自我披露行为和大脑功能。它将进行创新 分析关系中的每日积极和负面经历，以及与亲密关系和浪漫关系的分析 幸福感的变化。最后，它将继续深入持续的生物学（神经，荷尔蒙和 青春期的变化，并将其与先前和随后的社会过程以及心理健康相关。我们 提议在中间青少年期间紧密的关系质量和神经发育不仅是 预测并发和近乎未来的心理健康，但也是一系列级联发展的一部分 以及早期的生物学和社会心理变化运动的风险过程。