Training in Translational Immunology Research

转化免疫学研究培训

• 批准号: 10311071
• 负责人: Megan Sykes
• 金额: $ 30.98万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10311071
• 关键词: Immunology; Research; Training

Project Summary The field of immunology has exploded in the past decade, mainly as a result of technical developments enabling the study of complex organized structures and systems. Translational immunology research is immunological research that is oriented toward human immune diseases or therapies, ultimately aiming to convert basic discoveries made in laboratories into improved clinical therapies. Translational immunology encompasses molecular and animal research that addresses human diseases while emphasizing studies of the human immune system in an iterative “bench to bedside and back” approach. Because control of immunological processes is the goal of research in cancer, infectious disease, transplantation and autoimmunity, knowledge gained in one area is relevant to the other areas of applied immunology, resulting in a need for “horizontal translation” between disciplines. In order to harness the revolutionary leaps that have been made in our ability to study and control the human immune system, multidisciplinary training is needed that integrates knowledge from multiple disciplines at the basic and clinical levels and teaches young scientists how to use and analyze big data obtained from high throughput platforms such as next generation sequencing, proteomics, lipidomics and metabolomics. Analyzing these datasets increasingly demands cutting-edge bioinformatics capabilities that must be integrated into training the next generation of translational immunologists. We are proposing an integrative training program to meet this need by bringing together 29 established investigators at Columbia University Irving Medical Center (CUIMC) and offering mentored research opportunities in six complementary fields of immunology: basic immunology, developmental immunology, immunity to pathogens, tumor immunology, transplantation . immunology and autoimmunity. Cutting-edge research along these themes will be supported by the outstanding Department of Systems Biology at CUIMC. We believe this comprehensive program will expose trainees to cutting edge translational immunology research that integrates bioinformatics analyses The ultimate goal of our program is to provide fellows with the necessary competence to become future leaders in translational immunology.

项目概要 免疫学领域在过去十年中呈爆炸式增长，主要是由于技术的发展使得 对复杂组织结构和系统的研究。转化免疫学研究是免疫学的 针对人类免疫疾病或疗法的研究，最终旨在转化基础免疫疾病 实验室的发现改进了临床疗法。转化免疫学包括 解决人类疾病的分子和动物研究，同时强调人类免疫研究 系统采用迭代的“从工作台到床边再到后面”的方法。因为免疫过程的控制是 癌症、传染病、移植和自身免疫研究的目标，在其中获得的知识 领域与应用免疫学的其他领域相关，因此需要在它们之间进行“水平翻译” 学科。为了利用我们的学习和控制能力所取得的革命性飞跃 人体免疫系统需要多学科培训，整合多个领域的知识 基础和临床层面的学科，并教授年轻科学家如何使用和分析获得的大数据 来自高通量平台，如下一代测序、蛋白质组学、脂质组学和代谢组学。 分析这些数据集越来越需要必须集成的尖端生物信息学能力 培训下一代转化免疫学家。我们提出综合培训计划 为了满足这一需求，哥伦比亚大学欧文医学中心汇集了 29 名资深研究人员 （CUIMC）并在免疫学的六个互补领域提供指导研究机会：基础 免疫学、发育免疫学、病原体免疫、肿瘤免疫学、移植 。 免疫学和自身免疫。围绕这些主题的前沿研究将得到杰出学者的支持 CUIMC 系统生物学系。我们相信这个全面的计划将使学员能够接触到 整合生物信息学分析的尖端转化免疫学研究我们的最终目标 该计划旨在为研究员提供必要的能力，使其成为转化领域的未来领导者 免疫学。