Training in Translational Immunology Research

项目摘要 免疫学领域在过去十年中呈爆炸性增长，这主要是由于技术发展使 对复杂的有组织的结构和系统的研究。翻译免疫学研究是免疫学的 以人类免疫疾病或疗法为导向的研究，最终目标是将基础 实验室中的发现转化为改进的临床疗法。翻译免疫学包括 针对人类疾病的分子和动物研究，同时强调对人类免疫的研究 系统采用迭代的“从床到床、从床到背”的方法。因为对免疫过程的控制 癌症、传染病、移植和自身免疫的研究目标，集知识于一身 该领域与应用免疫学的其他领域相关，因此需要在 纪律。为了利用我们的学习和控制能力已经取得的革命性飞跃 对于人类免疫系统，需要多学科的培训，将来自 基础和临床层面的学科，并教年轻科学家如何使用和分析获得的大数据 来自高通量平台，如下一代测序、蛋白质组学、脂类组学和代谢组学。 分析这些数据集越来越需要必须集成的尖端生物信息学能力 培养下一代转化型免疫学家。我们正在提出一项综合培训计划 为了满足这一需求，哥伦比亚大学欧文医学中心的29名资深研究人员聚集在一起 (CUIMC)，并在免疫学的六个互补领域提供指导研究机会：基础 免疫学、发育免疫学、病原体免疫学、肿瘤免疫学、移植 。 免疫学和自身免疫学。这些主题的前沿研究将得到杰出的 清华大学系统生物学系。我们相信，这一综合计划将使学员接触到 结合生物信息学的尖端翻译免疫学研究分析了我们的最终目标 计划是为研究员提供必要的能力，使其成为未来翻译领域的领导者 免疫学。

Project Summary The field of immunology has exploded in the past decade, mainly as a result of technical developments enabling the study of complex organized structures and systems. Translational immunology research is immunological research that is oriented toward human immune diseases or therapies, ultimately aiming to convert basic discoveries made in laboratories into improved clinical therapies. Translational immunology encompasses molecular and animal research that addresses human diseases while emphasizing studies of the human immune system in an iterative “bench to bedside and back” approach. Because control of immunological processes is the goal of research in cancer, infectious disease, transplantation and autoimmunity, knowledge gained in one area is relevant to the other areas of applied immunology, resulting in a need for “horizontal translation” between disciplines. In order to harness the revolutionary leaps that have been made in our ability to study and control the human immune system, multidisciplinary training is needed that integrates knowledge from multiple disciplines at the basic and clinical levels and teaches young scientists how to use and analyze big data obtained from high throughput platforms such as next generation sequencing, proteomics, lipidomics and metabolomics. Analyzing these datasets increasingly demands cutting-edge bioinformatics capabilities that must be integrated into training the next generation of translational immunologists. We are proposing an integrative training program to meet this need by bringing together 29 established investigators at Columbia University Irving Medical Center (CUIMC) and offering mentored research opportunities in six complementary fields of immunology: basic immunology, developmental immunology, immunity to pathogens, tumor immunology, transplantation . immunology and autoimmunity. Cutting-edge research along these themes will be supported by the outstanding Department of Systems Biology at CUIMC. We believe this comprehensive program will expose trainees to cutting edge translational immunology research that integrates bioinformatics analyses The ultimate goal of our program is to provide fellows with the necessary competence to become future leaders in translational immunology.