Administrative Core

摘要 行政核心(核心A)将提供所有科学、管理、后勤、 和财务监督，以促进和协调本文件中所述的研究 程序。集中管理是高效协调、管理的关键 并执行每个项目。行政核心将确保成年人学习 艾滋病毒研究(项目1)，儿童艾滋病毒研究(项目2)，临床前非人类灵长类 (NHP)研究(项目3)，数学建模和生物信息学核心(核心B) 遵守这些章节中描述的时间表和可交付成果。 行政核心将每月组织两次电话会议，并定期在- 调查人员之间的人员会议，与临床现场的接口，维护 所有临床前的监管审批，提供财务和后勤监督，管理 分包，并协调与科学咨询委员会和艾滋病司的会议 项目官员。这种详细的行政和管理结构将确保 所有研究的重点仍然放在推进 对艾滋病病毒反弹的认识

ABSTRACT The Administrative Core (Core A) will provide all scientific, managerial, logistic, and financial oversight to facilitate and to coordinate the studies described in this program. Centralized administration is critical for efficient coordination, management and execution each project. The Administrative Core will ensure that the Adults studies of HIV (Project 1), Pediatric HIV studies (Project 2), the preclinical non-human primate (NHP) studies (Project 3), the Mathematical Modeling and Bioinformatics Core (Core B) adhere to the timelines and deliverables described in those sections. The Administrative Core will organize twice-monthly conference calls and regular in- person meetings among the investigators, interface with clinical sites, maintain regulatory approvals for all preclinical, provide fiscal and logistic oversight, manage subcontracts, and coordinate meetings with the Scientific Advisory Board and DAIDS Program Officials. This detailed administration and management structure will ensure that all the studies remain focused on the overall objective of advancing the understanding of HIV rebound