EFFECT OF PHTHALATES ON PRIMATE PREGNANCY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 有明确的证据表明，一些邻苯二甲酸酯对雄性哺乳动物的睾丸发育有直接影响，导致先天性缺陷。这些研究中的缺陷仅限于雄激素分泌的靶细胞，因此已知的缺陷仅限于男性和性发育。然而，以前的所有实验研究都采用了啮齿动物模型，这些动物模型不依赖于雄激素的产生来普遍支持怀孕。在这项研究中，我们假设邻苯二甲酸酯将以胎儿灵长类动物的肾上腺为靶点，并通过限制肾上腺类固醇的产生来扰乱妊娠，肾上腺类固醇是胎盘产生妊娠雌激素所必需的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is clear evidence that some phthalates have a direct effect on the developing testis resulting in congenital defects in male mammals. Defects in these studies have been limited to androgen secreting target cells thus the known defects are limited to males and sexual development. However, all previous experimental studies have employed rodent animal models which do not depend upon androgen production for general support of pregnancy. In this study we hypothesize that phthalates will target the fetal primate adrenal and disrupt pregnancy by limiting the production of adrenal steroids which are essential for placental production of the estrogens of pregnancy.