Intravascular Deployment of a Wirelessly Powered Micro-Pacer

无线供电微型起搏器的血管内部署

• 批准号: 10358490
• 负责人: Tzung K Hsiai
• 金额: $ 39.77万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-05 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10358490
• 关键词: 3-Dimensional; Address; Anatomy; Anterior; Architecture; Bradycardia; Brain; Cardiac; Cardiovascular system; Charge; Clinical; Collaborations; Consumption; Coupling; Development; Devices; Diagnostic; Effectiveness; Electric Capacitance; Electrical Engineering; Electrocardiogram; Electrodes; Encapsulated; Engineering; Family suidae; Feedback; Frequencies; Goals; Gold; Heart; Immune; Implant; In Situ; Lead; Length; Life; Magnetism; Mechanics; Mediating; Metabolic; Modeling; Oils; Output; Pacemakers; Patients; Peripheral Nerve Stimulation; Pre-Clinical Model; Procedures; Research; Semiconductors; Silicone Oils; Spinal Cord; Stomach; Surface; System; Technology; Therapeutic; Time; Variant; absorption; base; biomaterial compatibility; cardiac vein; circadian; density; design; experience; flexibility; implantable device; in vivo; integrated circuit; metal oxide; multi-electrode arrays; neural stimulation; neuroregulation; novel; parylene; parylene C; printed circuit board; response; sample fixation; sensor; subcutaneous; transmission process; voltage; wireless

Abstract Despite recent advances in implantable biomedical devices, the utilization of wireless power delivery continues to be a challenge due to anatomical size constraints that limit sufficient power transfer. In addition to pacemakers, implantable stimulators, including neuromodulation devices used for spinal cord, deep brain, and peripheral nerve stimulation, are confined by the same lead-based architecture. Thus, developing wireless power transfer for implantable devices, including the pacemaker, has the potential to mitigate a host of device- related complications. A primary challenge in inductively powered biomedical devices remains in developing a micro-scale receiver antenna with sufficient power output while minimizing transmitter power consumption over an anatomically and wirelessly feasible range. Eliminating the pacing leads, bulky batteries, fixation-associated mechanical burden, and repeated procedures for battery replacement and device retraction remains an unmet clinical need. In this context, we seek to advance a long-range inductively powered wireless and batteryless micro (µ)-system with sufficient power for pacing functionality. Our encouraging preliminary results support the feasibility of a pacing system with a subcutaneous unit and micro-scale pacer unit to induce sufficient power transfer for ex vivo pacing to a porcine heart. We hereby address the fundamental constraints of in vivo long- range pacing using an intravascular micro-pacing system. Our objective is to integrate advanced antenna and circuit design into a pacer system to enable intravascular deployment of wirelessly powered µ-pacer to the anterior cardiac vein (ACV) for pacing. Our goal is to eliminate the device fixation- and lead-related mechanical complications for optimal power transfer efficiency. To deliver our objective, we have three aims. In Aim 1, we will demonstrate the fundamental µ-antenna design and fabrication to enhance power transfer efficiency. In Aim 2, we will integrate CMOS technology and the novel parylene-on-oil encapsulation to enable intravascular deployment. In Aim 3, we will demonstrate the µ-pacer for real-time intravascular pacing in our pre-clinical model. Successful deployment of this wireless power transmission system provides the theoretical and experimental framework to overcome the anatomical size constraints that limit sufficient power transfer with translational implications for both cardiac and non-cardiac stimulation.

摘要 尽管植入式生物医学设备最近取得了进展，但无线电力输送的应用仍在继续 这是一个挑战，因为解剖尺寸的限制限制了足够的能量转移。除了……之外 起搏器，植入式刺激器，包括用于脊髓、脑深部和 外周神经刺激，都受到相同的铅基架构的限制。因此，开发无线 包括起搏器在内的植入式设备的能量转移有可能缓解一系列设备- 相关并发症。感应供电生物医学设备的主要挑战仍然是开发一种 微尺度接收器天线，具有足够的功率输出，同时将发射机功耗降至最低 一个解剖学上和无线上可行的射程。消除起搏导线、笨重的电池、与固定相关的 机械负担，以及电池更换和设备收回的重复程序仍然没有得到满足 临床需要。在这种背景下，我们寻求推进一种远程感应供电的无线和无电池 微(µ)-具有足够功率以实现起搏功能的系统。我们令人鼓舞的初步结果支持了 具有皮下单位和微型起搏器单位的起搏系统产生足够能量的可行性 将体外起搏转移到猪的心脏。我们在此解决体内长时间的基本限制- 使用血管内微起搏系统的射程起搏。我们的目标是将先进的天线和 将电路设计集成到起搏器系统中，使无线供电的微起搏器能够在血管内部署到 心脏前静脉(ACV)用于起搏。我们的目标是消除设备固定和铅相关的机械 最佳电能传输效率的复杂性。为了实现我们的目标，我们有三个目标。在目标1中，我们 将演示微天线的基本设计和制造，以提高功率传输效率。在……里面 目标2，将cmos技术与新型的对二甲苯-油包覆技术相结合，实现血管内 部署。在目标3中，我们将在临床前演示用于实时血管内起搏的µ起搏器 模特。该无线输电系统的成功部署提供了理论和实践依据 克服限制足够能量传递的解剖尺寸限制的实验框架 对于心脏刺激和非心脏刺激的翻译含义。