Quantitative Fundus Autofluorescence in Retinal Disorders
视网膜疾病中的定量眼底自发荧光
基本信息
- 批准号:10358501
- 负责人:
- 金额:$ 39.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-06-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AbbreviationsAcuteAddressAdverse effectsAgeAge related macular degenerationAllelesAnalysis of VarianceCellsCharacteristicsChoroideremiaClinicalConfidence IntervalsDark AdaptationDataDiagnosisDiseaseDisease ProgressionEthnic OriginEyeFemaleFluorescenceFundingFundusGenderGeneticGenotypeGlyoxalHumanHydroxychloroquineImageIndividualInferiorInfluentialsInvestigationLasersLegal BlindnessLesionLightLinkLipofuscinLiquid ChromatographyMeasuresMedical GeneticsMelaninsMembraneMethodsMonitorMosaicismMultimodal ImagingMutationNatural HistoryNormal RangeNuclearOphthalmoscopyOptical Coherence TomographyOutcome MeasureParticipantPathogenicityPatientsPatternPerformancePhenotypePhotoreceptorsPredispositionProcessProgressive DiseasePublic HealthPyruvaldehydeRab escort proteinRetinaRetinal DegenerationRetinal DiseasesRetinitis PigmentosaRetinol dehydrogenaseScanningSerousSignal TransductionSourceSpatial DistributionSpectrometry, Mass, Electrospray IonizationStandardizationStargardt&aposs diseaseStructure of retinal pigment epitheliumTestingTherapeuticThickToxic effectVisual AcuityWorkagedclinical diagnosisconfocal imagingdisorder of macula of retinafundus imaginggenetic testinginterestmaculamutation carrierretinal imagingtherapy outcome
项目摘要
Description: Project Summary and Relevance
The inherent autofluorescence (AF) of the fundus originates from RPE bisretinoid lipofuscin. While RPE
lipofuscin is amassed even in healthy eyes, imaging of fundus AF by confocal scanning laser ophthalmoscopy
(cSLO) has shown that the patterns and intensities of AF deviate from normal in several retinal disorders.
Accordingly, we previously demonstrated that a standardized approach to quantifying short wavelength fundus
AF (qAF) can assist in the diagnosis of retinal disease, in the monitoring of disease progression and in the
assessment of therapeutic outcomes.
To enable these investigations we have gathered normative qAF data from a large number of participants with
healthy eye status (aged 6-60) so as to establish ranges of qAF values with respect to age, gender and
ethnicity. Going forward we will use these normal values to determine whether bisretinoid lipofuscin
accumulation, a cellular burden that distinguishes RPE cells, confers susceptibility to the adverse effects of
HCQ on retina and whether qAF levels in inferior macula can serve as an early sign of HCQ toxicity (Specific
Aim 1). We will also determine why female carriers of choroideremia, present with reduced RPE lipofuscin
measured as qAF (Specific Aim 2). Using the qAF approach we will test for a relationship between the loss of
the ellipsoid zone in SD-OCT images and changes in short wavelength fundus autofluorescence (SW-AF)
intensities in patients diagnosed with central serous chorioretinopathy (Specific Aim 3). Homozygous mutations
in ABCA4 are well known to confer elevated qAF although the spatial distribution of the fluorescence intensity
is not uniform. By multi-modal imaging we will elucidate the underlying structural basis of this topographic
distribution (Specific Aim 4).
In summary, the studies proposed in this application will examine the contribution that the lipofuscin of retina
makes to the onset and progression of several retinal diseases and will demonstrate that quantitation of fundus
AF facilitates the diagnosis and monitoring of some retinal disorders.
描述:项目摘要和相关性
眼底固有的自体荧光(AF)来源于RPE双维A酸脂褐素。而RPE
即使在健康的眼睛中也有脂褐素积聚。共焦扫描激光眼底镜对眼底房颤的成像
(CSLO)的研究表明,在一些视网膜疾病中,房颤的模式和强度偏离了正常。
因此,我们以前证明了一种量化短波长眼底的标准化方法
房颤(QAF)有助于视网膜疾病的诊断、病情进展的监测和治疗。
对治疗结果的评估。
为了进行这些调查,我们从大量参与者那里收集了标准化的QAF数据
健康的眼睛状况(6-60岁),以建立年龄、性别和年龄相关的QAF值范围
种族问题。展望未来,我们将使用这些正常值来确定双维A酸脂褐素
堆积,一种区别于RPE细胞的细胞负担,使人对
HCQ对视网膜的影响以及黄斑下部的QAF水平是否可以作为HCQ中毒的早期迹象(特异性
目标1)。我们还将确定为什么女性脉络膜血症携带者RPE脂褐素降低
以QAF(特定目标2)衡量。使用QAF方法,我们将测试损失与
SD-OCT图像中的椭球区与眼底短波自体荧光的变化
诊断为中心性浆液性脉络膜视网膜病变患者的强度(特定目标3)。纯合突变
在ABCA4中,众所周知,尽管荧光强度的空间分布增加了QAF
是不统一的。通过多模式成像,我们将阐明这一地形的潜在结构基础
分配(具体目标4)。
总之,在本申请中提出的研究将检查视网膜的脂褐素的贡献
与几种视网膜疾病的发生和发展有关,并将证明眼底定量
房颤有助于某些视网膜疾病的诊断和监测。
项目成果
期刊论文数量(26)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Photoreceptor cells as a source of fundus autofluorescence in recessive Stargardt disease.
- DOI:10.1002/jnr.24252
- 发表时间:2019-01
- 期刊:
- 影响因子:4.2
- 作者:Paavo M;Lee W;Allikmets R;Tsang S;Sparrow JR
- 通讯作者:Sparrow JR
Retinal Pigment Epithelium Atrophy in Recessive Stargardt Disease as Measured by Short-Wavelength and Near-Infrared Autofluorescence.
- DOI:10.1167/tvst.10.1.3
- 发表时间:2021-01
- 期刊:
- 影响因子:3
- 作者:Jauregui R;Nuzbrokh Y;Su PY;Zernant J;Allikmets R;Tsang SH;Sparrow JR
- 通讯作者:Sparrow JR
Light Come Shining: Fundus Autofluorescence.
光来闪耀:眼底自发荧光。
- DOI:10.3928/01913913-20180709-01
- 发表时间:2018
- 期刊:
- 影响因子:1.2
- 作者:Sparrow,JanetR
- 通讯作者:Sparrow,JanetR
MULTIMODAL IMAGING OF DISEASE-ASSOCIATED PIGMENTARY CHANGES IN RETINITIS PIGMENTOSA.
- DOI:10.1097/iae.0000000000001256
- 发表时间:2016-12
- 期刊:
- 影响因子:0
- 作者:Schuerch K;Marsiglia M;Lee W;Tsang SH;Sparrow JR
- 通讯作者:Sparrow JR
Clinical spectrum, genetic complexity and therapeutic approaches for retinal disease caused by ABCA4 mutations.
- DOI:10.1016/j.preteyeres.2020.100861
- 发表时间:2020-11
- 期刊:
- 影响因子:17.8
- 作者:Cremers FPM;Lee W;Collin RWJ;Allikmets R
- 通讯作者:Allikmets R
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Janet Ruthe Sparrow其他文献
Janet Ruthe Sparrow的其他文献
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{{ truncateString('Janet Ruthe Sparrow', 18)}}的其他基金
Precision genome surgery in autologous stem cell transplant
自体干细胞移植中的精准基因组手术
- 批准号:
9811117 - 财政年份:2019
- 资助金额:
$ 39.29万 - 项目类别:
Retinal Disease Promoted by Iron-Induced Bisretinoid Oxidation
铁诱导的双维A酸氧化促进视网膜疾病
- 批准号:
10402760 - 财政年份:2018
- 资助金额:
$ 39.29万 - 项目类别:
Retinal Disease Promoted by Iron-Induced Bisretinoid Oxidation
铁诱导的双维A酸氧化促进视网膜疾病
- 批准号:
10090468 - 财政年份:2018
- 资助金额:
$ 39.29万 - 项目类别:
Quantitative Fundus Autofluorescence in Retinal Disorders
视网膜疾病中的定量眼底自发荧光
- 批准号:
8619402 - 财政年份:2014
- 资助金额:
$ 39.29万 - 项目类别:
Quantitative Fundus Autofluorescence in Retinal Disorders
视网膜疾病中的定量眼底自发荧光
- 批准号:
9084593 - 财政年份:2014
- 资助金额:
$ 39.29万 - 项目类别:
Imaging, Histology and Functional Diagnostics Core
影像、组织学和功能诊断核心
- 批准号:
10273969 - 财政年份:2010
- 资助金额:
$ 39.29万 - 项目类别:
Imaging, Histology and Functional Diagnostics Core
影像、组织学和功能诊断核心
- 批准号:
10475818 - 财政年份:2010
- 资助金额:
$ 39.29万 - 项目类别:
Imaging, Histology and Functional Diagnostics Core
影像、组织学和功能诊断核心
- 批准号:
10681428 - 财政年份:2010
- 资助金额:
$ 39.29万 - 项目类别:
IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLS
脂褐质对视网膜色素上皮细胞的影响
- 批准号:
6086563 - 财政年份:2000
- 资助金额:
$ 39.29万 - 项目类别:
Impact of Lipofuscin in Retinal Pigment Epithelial Cells
脂褐质对视网膜色素上皮细胞的影响
- 批准号:
8511140 - 财政年份:2000
- 资助金额:
$ 39.29万 - 项目类别:
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