Statistics Core

统计核心

• 批准号: 10359066
• 负责人: ROBERT J GRAY
• 金额: $ 312.79万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-29 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10359066
• 关键词: Address; American College of Radiology Imaging Network; Biometry; Computational Biology; Dana-Farber Cancer Institute; Data Analyses; Data Reporting; Development; Diagnostic Imaging; Eastern Cooperative Oncology Group; Lead; Leadership; Manuscripts; Methodology; Mission; Monitor; Outcome; Process; Reporting; Research; Research Personnel; Research Support; Safety; Structure; Therapeutic Trials; Time; Translational Research; Universities; Work; data management; design; experience; imaging study; programs; statistics

The Statistics core activities are performed by the Biostatistics Center of the ECOG-ACRIN Statistics and Data Management Center. The Biostatistics Center is responsible for design and analysis of all ECOG-ACRIN studies. The Biostatistics Center has two components, SDMC-DFCI at the Dana-Farber Cancer Institute, which has primary responsibility for therapeutic trials, and SDMC-Brown at Brown University, which has primary responsibility for diagnostic and imaging studies. The Center includes a group of highly experienced statisticians who are led by Drs. Constantine Gatsonis and Robert Gray. The Center also has expertise in computational biology and has access to leading experts in this field at DFCI and Brown. The research structure of ECOG-ACRIN is organized into a number of scientific committees, which are responsible for developing the Group's studies. ECOG-ACRIN statisticians are assigned to work with specific scientific committees. They participate fully in the development of scientific directions and collaborate on study concepts from the earliest discussions within the committees through the entire process of development. Statisticians are responsible for developing statistical designs and analysis plans to robustly address study's objectives. The Biostatistics Center is responsible for comprehensive monitoring of all EA studies, including producing reports for monitoring study progress and safety and producing confidential reports for the Data Safety Monitoring Committee, which include interim analyses of outcome when appropriate. Statisticians also produce comprehensive reports on study results at the completion of studies and collaborate with lead study investigators on the development of manuscripts. Statisticians also collaborate with investigators on design and analysis of the ECOG- ACRIN's translational science initiatives.

统计核心活动由 ECOG-ACRIN 统计生物统计中心执行 和数据管理中心。生物统计中心负责所有数据的设计和分析 ECOG-ACRIN 研究。生物统计中心有两个组成部分：位于丹娜—法伯癌症研究所的 SDMC-DFCI 主要负责治疗试验的癌症研究所和布朗大学的 SDMC-Brown 大学主要负责诊断和成像研究。该中心包括一个 由博士领导的一群经验丰富的统计学家。康斯坦丁·加特索尼斯和罗伯特·格雷。 该中心还拥有计算生物学方面的专业知识，并可以接触到该领域的领先专家 在 DFCI 和布朗。 ECOG-ACRIN 的研究结构由多个科学委​​员会组成，分别是 负责开展小组的研究。 ECOG-ACRIN 统计员被指派与 具体的科学委员会。他们充分参与科学方向的制定和 从委员会内部最早的讨论到整个研究概念的合作 发展过程。统计学家负责开发统计设计和分析 计划强有力地实现研究目标。生物统计中心负责综合统计 监测所有 EA 研究，包括生成监测研究进展和安全性的报告，以及 为数据安全监测委员会制作机密报告，其中包括临时报告 适当时对结果进行分析。统计学家还制作综合研究报告 研究完成后得出结果，并与主要研究人员合作开发 手稿。统计学家还与研究人员合作设计和分析 ECOG- ACRIN 的转化科学计划。