Statistics Core

统计核心活动由ECOG-ACRIN统计的生物统计中心执行 数据管理中心。生物统计中心负责设计和分析所有 ECOG-ACRIN研究。生物统计中心有两个组成部分，SDMC-DFCI在达纳法伯 主要负责治疗试验的癌症研究所和布朗大学的SDMC-Brown 该大学主要负责诊断和成像研究。该中心包括一个 由Constantine Gatsonis博士和Robert Gray博士领导的一组经验丰富的统计学家。 该中心还拥有计算生物学方面的专业知识，并能接触到该领域的顶尖专家 在DFCI和布朗。 ECOG-ACRIN的研究结构分为若干科学委员会， 负责编写小组的研究报告。ECOG-ACRIN统计学家被指派与 具体的科学委员会。他们充分参与科学方向的发展， 从委员会内部的最早讨论到整个研究概念的合作 发展的过程。统计学家负责开发统计设计和分析 计划有力地解决研究的目标。生物统计中心负责全面的 监测所有EA研究，包括生成用于监测研究进展和安全性的报告，以及 为数据安全监查委员会编制机密报告，包括临时报告 适当时分析结果。统计学家还编写关于研究的综合报告 研究完成时的结果，并与主要研究者合作制定 手稿统计学家还与研究者合作设计和分析ECOG- ACRIN的转化科学倡议。

The Statistics core activities are performed by the Biostatistics Center of the ECOG-ACRIN Statistics and Data Management Center. The Biostatistics Center is responsible for design and analysis of all ECOG-ACRIN studies. The Biostatistics Center has two components, SDMC-DFCI at the Dana-Farber Cancer Institute, which has primary responsibility for therapeutic trials, and SDMC-Brown at Brown University, which has primary responsibility for diagnostic and imaging studies. The Center includes a group of highly experienced statisticians who are led by Drs. Constantine Gatsonis and Robert Gray. The Center also has expertise in computational biology and has access to leading experts in this field at DFCI and Brown. The research structure of ECOG-ACRIN is organized into a number of scientific committees, which are responsible for developing the Group's studies. ECOG-ACRIN statisticians are assigned to work with specific scientific committees. They participate fully in the development of scientific directions and collaborate on study concepts from the earliest discussions within the committees through the entire process of development. Statisticians are responsible for developing statistical designs and analysis plans to robustly address study's objectives. The Biostatistics Center is responsible for comprehensive monitoring of all EA studies, including producing reports for monitoring study progress and safety and producing confidential reports for the Data Safety Monitoring Committee, which include interim analyses of outcome when appropriate. Statisticians also produce comprehensive reports on study results at the completion of studies and collaborate with lead study investigators on the development of manuscripts. Statisticians also collaborate with investigators on design and analysis of the ECOG- ACRIN's translational science initiatives.