Proteomics Laboratory Shared Resources

蛋白质组学实验室共享资源

• 批准号: 10358547
• 负责人: Beatrix Magdalena Ueberheide
• 金额: $ 6.52万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10358547
• 关键词: Biochemistry; Biological; Cancer Center; Cancer Center Support Grant; Collaborations; Custom; Data Analyses; Doctor of Philosophy; Education; Educational process of instructing; Ensure; Experimental Designs; Individual; Label; Laboratories; Mass Spectrum Analysis; Mission; Molecular; Paper; Peptides; Pharmacology; Post-Translational Protein Processing; Postdoctoral Fellow; Preparation; Protein Analysis; Proteomics; Proteomics Shared Resource; Publications; Research; Research Personnel; Resource Sharing; Resources; Sampling; Scientist; Students; Technical Expertise; Techniques; Technology; Training; base; data analysis pipeline; experience; graduate student; hands on instruction; innovation; instrumentation; member; method development; novel; operation; professor; protein complex

Abstract/Project Summary PROTEOMICS RESOURCE LABORATORY SHARED RESOURCE (PRL) The Proteomics Resource Laboratory (PRL) provides support for mass spectrometry-based proteomics analysis for all Perlmutter Cancer Center (PCC) investigators through a centralized facility, with state-of-the-art instrumentation and highly specialized technical expertise. Under the direction of Dr. Beatrix Ueberheide, a well-established expert in biological mass spectromety, PRL was established 5 years ago to expand upon the successful Proteomics Core. PRL aids scientific discovery at PCC by providing access to specialized expertise and state-of-the-art instrumentation for the analysis of proteins and peptides using mass spectrometry (MS). A special focus of the laboratory is assistance with experimental design and full support for downstream data analysis, often involving innovative data analysis pipelines. Significant economies of scale are achieved by this centralization of resources. PRL achieves its mission via four Specific Aims: Aim 1) To provide mass spectrometry-based, state-of-the-art proteomics technologies to PCC investigators and full downstream data analysis support; Aim 2) To provide highly customized support tailored to specific projects and research questions of PCC investigators; Aim 3) To develop and implement novel techniques to ensure continued support of state-of-the-art proteomics technology for PCC investigators; Aim 4) To provide education to graduate students and post-doctoral researchers on proteomics techniques through graduate teaching and close collaboration with PCC investigators.

摘要/项目摘要 蛋白质组学资源实验室共享资源 (PRL) 蛋白质组学资源实验室 (PRL) 为基于质谱的方法提供支持 通过一个集中的数据库为所有 Perlmutter 癌症中心 (PCC) 研究人员进行蛋白质组学分析 设施，拥有最先进的仪器和高度专业的技术知识。在下面 著名生物量专家 Beatrix Ueberheide 博士的指导 PRL 成立于 5 年前，旨在扩展成功的蛋白质组学 核。 PRL 通过提供专业知识和知识来帮助 PCC 进行科学发现 使用质量分析蛋白质和肽的最先进仪器 光谱测定（MS）。实验室的一个特别重点是协助实验设计和 全面支持下游数据分析，通常涉及创新的数据分析管道。 这种资源集中可以实现显着的规模经济。 PRL 达到 其使命通过四个具体目标实现： 目标 1) 提供基于质谱的最先进技术 为 PCC 研究人员提供蛋白质组学技术和完整的下游数据分析支持；目的 2）针对特定项目和研究问题提供高度定制的支持 PCC 调查员；目标 3）开发和实施新技术以确保持续 为 PCC 研究人员提供最先进的蛋白质组学技术支持；目标 4) 提供 对研究生和博士后研究人员进行蛋白质组学技术教育 通过研究生教学以及与 PCC 研究人员的密切合作。