UT Southwestern Center for Translational Medicine

联系PD/PI：Toto，Robert D 总体：项目摘要/摘要 德克萨斯大学西南分校的转化医学中心(CTM)是由7位学者合作的 机构、5个医疗保健系统、6个教学医院和北德克萨斯社区。我们的任务是 至 通过创新和教育改善当地和全球社区的健康。 在过去的两年中， 我们的CTSA促进了创新，并改变了我们计划中心的文化和景观。我们 培训了1,000名翻译员工，共同领导了应计到临床的形成 试验CTSA网络并建立了新的翻译技术、方法和流程，对 每一级的翻译过程。我们很早就让我们的当地社区参与设计和实施 临床研究。我们还建立了新的合作研究服务以及教育和培训计划 旨在解决我们社区和国家面临的最大健康挑战。通过这些努力， CTM已经产生了相当大的动力来推动翻译科学的发展，这是由一个高度 团队科学和社区参与的硬连接的协作环境。 在未来5年内，我们将优化CTSA集线器的组织结构，以实现更高效的翻译 将生物医学发现转化为干预措施，最终将改善我们当地的健康 并与CTSA网络合作，为更广泛的美国人口提供服务。我们会发现， 开发、演示和传播新的信息学和人工智能解决方案，以应对 各级翻译中存在的问题。与中心合作伙伴和相关国家CTSA网络协作， 我们建议开发新的方法和程序，以进一步将研究与实践相结合 护理点。在我们成功的基础上，我们现在正准备实现CTSA的五个主要目标 该计划和转化医学中心有以下具体目标： 目标1.培养一支训练有素、技能高超、多样化的翻译劳动力队伍。 目标2.灌输社区参与和团队科学。 目标3.将不同人群的生命周期整合到临床和转化性研究中。 目标4.推动创新和新的科学方法和过程。 目标5.开发创新的信息学解决方案，以克服翻译障碍。 目标6.增加劳动力异质性。 影响：随着我们高度集成的动态研究和培训环境到位，我们的中心将拥有 对翻译科学领域产生了强大而持久的影响。我们将在以下方面实现重大飞跃： 临床和转化性研究的范围、效率和质量，造福于我们的中心和国家 财团。我们将与领先创新与协作中心、试验创新中心合作 网络和健康数据中心，以弥合科学发现和改善健康之间的差距。 项目摘要/摘要页164 联系PD/PI：Toto，Robert D O.总体而言：

Contact PD/PI: Toto, Robert D OVERALL: PROJECT SUMMARY/ABSTRACT The Center for Translational Medicine (CTM) at UT Southwestern is a collaboration among 7 academic institutions, 5 health care systems, 6 teaching hospitals and the North Texas community. Our mission is to improve health in local and global communities through innovation and education. Over the past two funding cycles, our CTSA catalyzed innovation and transformed the culture and landscape of our program Hub. We have trained >1,000 members of the translational workforce, co-led the formation of the Accrual to Clinical Trials CTSA network and established new translational technologies, methods, and processes critical to the translational process at every level. We engaged our local communities early on in the design and conduct of clinical research. We also formed new collaborative research services and education and training programs designed to address the top health challenges of our community and the nation. Through these efforts, the CTM has generated considerable momentum toward advancing translational science propelled by a highly collaborative environment that is hard-wired for Team Science and Community Engagement. Over the next 5 years, we will optimize the organization of our CTSA Hub for more efficient translation of biomedical discoveries into interventions that will ultimately result in the improved health of both our local populations and, in collaboration with the CTSA Network, the broader U.S. population. We will discover, develop, demonstrate, and disseminate new informatics and artificial intelligence solutions to challenging problems in translation at all levels. In collaboration with Hub partners and relevant national CTSA networks, we propose to develop new methods and processes to further the integration of research into practice at the point of care. Building on our success, we are now poised to achieve the five key objectives of the CTSA Program and the Center for Translational Medicine with the following Specific Aims: Aim 1. Produce a well-trained, highly skilled, diverse Translational Workforce. Aim 2. Inculcate Community Engagement and Team Science. Aim 3. Integrate diverse populations across the lifespan into clinical and translational research. Aim 4. Promote innovation and new scientific Methods and Processes. Aim 5. Develop innovative Informatics solutions to overcome translational roadblocks. Aim 6. Increase Workforce Heterogeneity. Impact: With our highly-integrated dynamic research and training environment in place, our Hub will have a powerful and sustained impact on the field of translational science. We will make a major leap forward in the scope, efficiency, and quality of clinical and translational research for the benefit of our Hub and the national consortium. We will collaborate with the Center for Leading Innovation and Collaboration, the Trial Innovation Network, and the Center for Data to Health to bridge the gap between scientific discovery and improved health. Project Summary/Abstract Page 164 Contact PD/PI: Toto, Robert D O. OVERALL: