UT Southwestern Center for Translational Medicine

德州大学西南转化医学中心

• 批准号: 10614619
• 负责人: ROBERT Daniel TOTO
• 金额: $ 793.3万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-26 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10614619
• 关键词: Acceleration; Address; Adoption; Artificial Intelligence; Basic Science; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Data; Data Collection; Education; Ensure; Entrepreneurship; Environment; Faculty; Family; Fostering; Foundations; Funding; Goals; Health; Health Personnel; Healthcare; Healthcare Systems; Heterogeneity; Individual; Industry; Informatics; Institution; Intervention; Leadership; Longevity; Mentors; Methods; Mission; Outcome; Patients; Phase; Policy Maker; Population; Population Heterogeneity; Process; Published Comment; Qualitative Methods; Reproducibility; Research; Resources; Rural Community; Rural Population; Science; Scientist; Services; Special Population; Teaching Hospitals; Technology; Testing; Texas; Training; Training Programs; Training and Education; Translating; Translation Process; Translational Research; Translations; Underserved Population; Urban Community; Urban Population; academic program; biomedical scientist; catalyst; clinical practice; collaborative environment; community engagement; design; equity, diversity, and inclusion; ethnic diversity; improved; informatics training; innovation; member; multimodality; novel; novel strategies; personalized medicine; point of care; population health; pre-clinical; programs; racial diversity; recruit; research to practice; skills; success; tool; translational medicine; user-friendly

Contact PD/PI: Toto, Robert D OVERALL: PROJECT SUMMARY/ABSTRACT The Center for Translational Medicine (CTM) at UT Southwestern is a collaboration among 7 academic institutions, 5 health care systems, 6 teaching hospitals and the North Texas community. Our mission is to improve health in local and global communities through innovation and education. Over the past two funding cycles, our CTSA catalyzed innovation and transformed the culture and landscape of our program Hub. We have trained >1,000 members of the translational workforce, co-led the formation of the Accrual to Clinical Trials CTSA network and established new translational technologies, methods, and processes critical to the translational process at every level. We engaged our local communities early on in the design and conduct of clinical research. We also formed new collaborative research services and education and training programs designed to address the top health challenges of our community and the nation. Through these efforts, the CTM has generated considerable momentum toward advancing translational science propelled by a highly collaborative environment that is hard-wired for Team Science and Community Engagement. Over the next 5 years, we will optimize the organization of our CTSA Hub for more efficient translation of biomedical discoveries into interventions that will ultimately result in the improved health of both our local populations and, in collaboration with the CTSA Network, the broader U.S. population. We will discover, develop, demonstrate, and disseminate new informatics and artificial intelligence solutions to challenging problems in translation at all levels. In collaboration with Hub partners and relevant national CTSA networks, we propose to develop new methods and processes to further the integration of research into practice at the point of care. Building on our success, we are now poised to achieve the five key objectives of the CTSA Program and the Center for Translational Medicine with the following Specific Aims: Aim 1. Produce a well-trained, highly skilled, diverse Translational Workforce. Aim 2. Inculcate Community Engagement and Team Science. Aim 3. Integrate diverse populations across the lifespan into clinical and translational research. Aim 4. Promote innovation and new scientific Methods and Processes. Aim 5. Develop innovative Informatics solutions to overcome translational roadblocks. Aim 6. Increase Workforce Heterogeneity. Impact: With our highly-integrated dynamic research and training environment in place, our Hub will have a powerful and sustained impact on the field of translational science. We will make a major leap forward in the scope, efficiency, and quality of clinical and translational research for the benefit of our Hub and the national consortium. We will collaborate with the Center for Leading Innovation and Collaboration, the Trial Innovation Network, and the Center for Data to Health to bridge the gap between scientific discovery and improved health. Project Summary/Abstract Page 164 Contact PD/PI: Toto, Robert D O. OVERALL:

联系PD/PI：Toto，Robert D 总体：项目总结/摘要 该中心的转化医学（CTM）在UT西南是一个合作的7个学术 机构，5个医疗保健系统，6个教学医院和北德克萨斯州社区。我们的使命是 到 通过创新和教育改善当地和全球社区的健康。 在过去的两次融资中 我们的CTSA促进了创新，并改变了我们的计划中心的文化和景观。我们 培训了超过1，000名翻译人员，共同领导了Accrual to Clinical 试验CTSA网络和建立新的翻译技术，方法和流程的关键， 在各个层面的翻译过程。我们很早就让当地社区参与了 临床研究我们还建立了新的合作研究服务和教育培训计划 旨在解决我们社区和国家面临的最大健康挑战。通过这些努力， CTM已经产生了相当大的势头，推进转化科学的高度推动下， 协作环境，是硬连线的团队科学和社区参与。 在接下来的5年里，我们将优化CTSA中心的组织结构，以提高翻译效率。 将生物医学发现转化为干预措施，最终改善我们当地居民的健康状况， 人口，并与CTSA网络合作，更广泛的美国人口。我们会发现， 开发、展示和传播新的信息学和人工智能解决方案，以应对挑战 在各个层面的翻译问题。与中心合作伙伴和相关的国家CTSA网络合作， 我们建议开发新的方法和流程，以进一步将研究融入实践， 护理点。在我们成功的基础上，我们现在准备实现CTSA的五个主要目标 项目和转化医学中心具有以下具体目标： 目标1.培养一支训练有素、技能高超、多样化的翻译队伍。 目标2.灌输社区参与和团队科学。 目标3.将整个生命周期的不同人群整合到临床和转化研究中。 目标4。促进创新和新的科学方法和流程。 目标5。开发创新的信息学解决方案，克服翻译障碍。 目标6。增加劳动力异质性。 影响：随着我们高度集成的动态研究和培训环境的到位，我们的枢纽将有一个 对翻译科学领域产生了巨大而持久的影响。我们将在以下方面实现重大飞跃： 临床和转化研究的范围，效率和质量，有利于我们的中心和国家 财团我们将与领先创新与合作中心（The Center for Leading Innovation and Collaboration）合作， 网络和健康数据中心，以弥合科学发现和改善健康之间的差距。 项目摘要/摘要第164页 联系PD/PI：Toto，Robert D O.总体：

项目成果

Searching Full-Text Anatomic Pathology Reports Using Business Intelligence Software.

• DOI: 10.1016/j.jpi.2022.100014
• 发表时间: 2022
• 期刊: Journal of pathology informatics
• 作者: Arvisais-Anhalt S;Lehmann CU;Bishop JA;Balani J;Boutte L;Morales M;Park JY;Araj E
• 通讯作者: Araj E

Risk Prediction for Acute Kidney Injury in Patients Hospitalized With COVID-19.

• DOI: 10.1016/j.xkme.2022.100463
• 发表时间: 2022-06
• 期刊: Kidney medicine
• 影响因子: 3.9
• 作者: McAdams MC;Xu P;Saleh SN;Li M;Ostrosky-Frid M;Gregg LP;Willett DL;Velasco F;Lehmann CU;Hedayati SS
• 通讯作者: Hedayati SS

ChatGPT and the clinical informatics board examination: the end of unproctored maintenance of certification?

• DOI: 10.1093/jamia/ocad104
• 发表时间: 2023-06-19
• 期刊: JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
• 影响因子: 6.4
• 作者: Kumah-Crystal, Yaa;Mankowitz, Scott;Lehmann, Christoph U.
• 通讯作者: Lehmann, Christoph U.

AMIA's code of professional and ethical conduct 2022.

AMIA 2022 年职业和道德行为准则。

• DOI: 10.1093/jamia/ocac192
• 发表时间: 2022
• 期刊: Journal of the American Medical Informatics Association : JAMIA
• 作者: Petersen,Carolyn;Berner,EtaS;Cardillo,Anthony;FultzHollis,Kate;Goodman,KennethW;Koppel,Ross;Korngiebel,DianeM;Lehmann,ChristophU;Solomonides,AnthonyE;Subbian,Vignesh
• 通讯作者: Subbian,Vignesh

Applied Clinical Informatics Journal: A Brief History.

应用临床信息学杂志：简史。

• DOI: 10.1055/s-0042-1749165
• 发表时间: 2022
• 期刊: Applied clinical informatics
• 影响因子: 2.9
• 作者: Lehmann,ChristophU;Ball,MarionJ;Haux,Reinhold;Lehmann,JennaS
• 通讯作者: Lehmann,JennaS