UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)

UT 西南转化医学中心 (UL1/KL2/TL1)

• 批准号: 8915945
• 负责人: ROBERT Daniel TOTO
• 金额: $ 9.72万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-26 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8915945
• 关键词: Applications Grants; Area; Award; Bioinformatics; Biometry; Clinical; Clinical Research; Communities; Community Health; Detection; Devices; Diagnosis; Disease; Elements; Environment; Funding; Genomics; Goals; Grant; Health; Health Personnel; Health Sciences; Home environment; Hospitals; Human; Instruction; Intervention; Knowledge; Leadership; Malignant Neoplasms; Medical; Movement; Outcomes Research; Patient-Focused Outcomes; Pharmaceutical Preparations; Population Research; Population Sciences; Positioning Attribute; Prevention; Principal Investigator; Proteomics; Public Health; Recruitment Activity; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Scientist; Systems Biology; Texas; Training and Education; Translating; Translational Research; Translations; Validation; Vision; Work; biomedical informatics; clinical practice; commercialization; design; effective therapy; falls; improved; innovation; metabolomics; novel diagnostics; novel therapeutics; programs; stem cell biology; translational medicine

Program Director/Principal Investigator (Last, First, Middle): T o t O , R o b e r t D . PROJECT SUMMARY (See instmctions): The CTSA has had a major impact on the clinical and translational research (CTR) environment at UT Southwestern. Many new and highly successful programs in education and training, pilot grant awards, biomedical informatics (BMI), biostatistics, population research, community health sciences, and patient- centered outcomes research have been established. Concurrently, the CTSA stimulated UT Southwestern to invest heavily in CTR infrastructure by recruiting new clinical and translational researchers into leadership positions of major clinical departments, by creating a new research institute that focuses on stem cell biology and cancer and by greatly enhancing genomics, metabolomics, proteomics, bioinformatics, and systems biology. Two new, state-of-the art hospitals are under construction, to open in fall 2014, and they incorporate design elements that will support CTR. Our vision is to accelerate translation of new discoveries into clinical practice (T0-T4) by leveraging our scientific strengths. We will integrate and centralize our resources to work in an encouraging and collaborative research environment. Our three Specific Aims are to: 1) Enhance our Research Environment to Accelerate Translation of Discovery into Practice. We formed the Center for Translational Medicine (Center), directed by the CTSA PI, to serve as the new integrated home for our CTSA. The Center will coordinate and expand the clinical research enterprise while it educates clinical and translational researchers at every level. 2) Leverage Existinq and New Resources to Build on Four Innovative Programs in Translation including: a) Target Identification and Validation; b) Discovery in Humans; c) Intervention in Humans and d) Population Science and Community Engagement. 3) Share Knowledge and Discoverv. and Contribute to the Leadership of the National Consortium. We will share gains that are made in our programs in educational and translational research programs with the Texas Regional CTSA consortium and National CTSA Consortium. We will contribute to leadership in areas of translation including T0-T4 research, and discovery and commercialization of new drugs and devices. Our vision for accelerating CTR is well aligned with the new NCATS initiatives and takes full advantage of gains made in the previous funding. We will establish new and improved programs that will enable investigators to discover, translate and disseminate new knowledge that will improve the prevention, detection, diagnosis, and effective treatment of disease. RELEVANCE (See instructions): Improving the health of our nation requires a concerted effort by medical scientists, health care providers and public health policymakers. This grant application will provide the crucial infrastructure necessary for medical scientists to discover and apply new diagnostics and therapeutics for the detection, prevention, detection, diagnosis and effective treatment of disease. The goal is to accelerate the movement of these new discoveries into clinical practice to improve our nation's health in a safe and effective manner.

项目负责人/主要研究者（最后一名、第一名、中间名）：T o t O、R o B e r t D。 项目总结（见说明）： CTSA对UT的临床和转化研究（CTR）环境产生了重大影响 西南部许多新的和非常成功的教育和培训计划，试点赠款奖， 生物医学信息学（BMI）、生物统计学、人口研究、社区健康科学和患者- 建立了以结果为中心的研究。同时，CTSA刺激了UT西南 通过招募新的临床和转化研究人员进入领导层，大力投资CTR基础设施 通过创建一个专注于干细胞生物学的新研究所， 和癌症，并大大提高基因组学，代谢组学，蛋白质组学，生物信息学和系统 生物学两个新的，最先进的医院正在建设中，将于2014年秋季开放，他们 包含支持CTR的设计元素。我们的愿景是加速新发现的转化 临床实践（T0-T4）通过利用我们的科学优势。我们将整合和集中我们的 资源在一个令人鼓舞的和协作的研究环境中工作。我们的三个具体目标是 1）改善我们的研究环境，以加速将发现转化为实践。我们 成立了转化医学中心（中心），由CTSA PI指导，作为新的 为我们的CTSA提供了一个综合性的家。中心将协调和拓展临床研究事业 同时它为各个级别的临床和转化研究人员提供教育。2)利用传统和新 资源建立在四个创新的翻译计划，包括：a）目标识别和 验证; B）人类发现; c）人类干预和d）人口科学和社区 订婚3)分享知识和发现。并为国家的领导作出贡献 财团我们将分享我们在教育和转化研究项目中取得的成果 与德克萨斯州区域CTSA联盟和国家CTSA联盟合作。我们将有助于 在翻译领域的领导地位，包括T0-T4研究，以及新的发现和商业化 药物和设备。 我们加快CTR的愿景与新的NCATS计划保持一致，并充分考虑到 利用以前的资金取得的收益。我们将建立新的和改进的方案， 使调查人员能够发现、翻译和传播有助于改进预防工作的新知识， 检测、诊断和有效治疗疾病。 相关性（参见说明）： 改善我们国家的健康状况需要医学科学家、卫生保健提供者和 公共卫生政策制定者。这项拨款申请将提供必要的关键基础设施， 医学科学家发现和应用新的诊断和治疗方法，用于检测，预防， 检测、诊断和有效治疗疾病。我们的目标是加速这些 将新发现应用于临床实践，以安全有效的方式改善我们国家的健康。