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中文摘要
翻译
洛克菲勒大学临床和转化科学中心(CCTS)的总体愿景得到支持 通过CTSA计划,是开发,展示和传播创新计划,以创建一个模型, 临床研究企业建立在严谨、负责任和透明的报告以及科学诚信的基础上, 将突破性的发现转化为更好的人类健康。我们的首要目标是 KL2临床学者硕士学位课程是准备我们的学员成功,科学 独立的翻译研究人员,可以领导翻译团队开展改善人类健康的项目。 该计划的核心是一个指导的翻译研究经验,其中学者作为一个 翻译团队科学领导者,并开发,进行,分析和传播人类的结果 在一位杰出的高级科学导师的指导下, 翻译科学团队专家/教育工作者的骨干。这种经验是由一个说教的补充 课程包括临床和转化科学,生物统计学,生物信息学, 流行病学;由杰出的翻译研究者举办的每周临床研究研讨会;私人周刊 与研讨会发言人会晤;团队科学领导力培训;研究生水平的科学课程; 人文和转化科学特别活动;以及负责任的研究行为培训。我们 该计划受益于该计划导师的科学实力,其中10名导师是学者 在目前的赠款期间当选为国家科学院的成员。因此,我们的具体 目标是:1.将医生科学家和博士水平的卫生专业人员培养为杰出的, 独立的翻译研究人员在3年的指导KL2临床学者硕士学位课程, 包括:a)从概念到报告的人类参与者协议的领导,B)教学课程, 帮助学者掌握作为一个严格的独立翻译科学家的能力,c) 集中的指导和反馈,以发展团队科学领导能力,成功地 领导一个转化科学团队2.引入新的教育项目,最大限度地提高学者的教育水平 经验和能力,考虑各种各样的职业选择,以及受益于新兴的 技术和资源:a)团队科学领导培训,B)药物生产和配制, d)本体驱动的人类表型分析,e)搜索电子健康记录和因果推断,e)从 从发现到增进健康的产品,以及f)让社区作为全面合作伙伴参与。3.加强 实现尽可能高水平的严格性、再现性和报告(R3)的重要性,并协助 学者们在研究生涯的早期发展最佳实践,以便他们可以采用新的方法 和政策,以不断提高他们对不断发展的标准的遵守。
英文摘要
The overall vision of the Rockefeller University Center for Clinical and Translational Science (CCTS), supported by the CTSA program, is to develop, demonstrate, and disseminate innovative programs so as to create a model clinical research enterprise built on rigor, responsible and transparent reporting, and scientific integrity to empower translation of paradigm-breaking discoveries into better human health. The overarching goal of our KL2 Clinical Scholars Master's degree program is to prepare our trainees to be successful, scientifically independent, translational investigators who can lead translational teams on projects to improve human health. The core of the program is a mentored translational research experience in which the Scholar serves as a translational team science leader, and develops, conducts, analyzes, and disseminates the results of a human participant study under the guidance of a distinguished senior scientific mentor and with the assistance of a cadre of Translational Science Team Experts/Educators. This experience is complemented by a didactic curriculum including tutorials in Clinical and Translational Science, Biostatistics, Bioinformatics, and Epidemiology; a weekly Clinical Research Seminar by outstanding translational investigators; a private weekly meeting with the seminar speaker; team science leadership training; a graduate level scientific course; Humanities and Translational Science special events; and training in the Responsible Conduct of Research. Our program benefits from the scientific strength of the mentors in the program, with 10 of the mentors of Scholars during the current grant period being elected members of the National Academy of Sciences. Thus, our specific aims are: 1. To train physician scientists and doctoral level health professionals as outstanding, scientifically independent translational investigators in a 3 year mentored KL2 Clinical Scholars Master's degree program that includes: a) leadership of a human participant protocol from conception to reporting, b) a didactic curriculum to help the Scholar master the competencies to function as a rigorous independent translational scientist, c) focused instruction and feedback to develop the team science leadership competencies required to successfully lead a translational science team. 2. To introduce new educational programs to maximize Scholars' educational experience and ability to consider a wide variety of career choices, as well as benefit from emerging new technology and resources: a) Team science leadership training, b) Pharmaceutical production and formulation, d) Ontology-driven human phenotyping, e) Searching Electronics Health Records and causal inference, e) From discovery to health-enhancing product, and f) Engaging communities as full partners. 3. Reinforce the importance of achieving the highest possible levels of rigor, reproducibility, and reporting (R3) and assist Scholars in developing best practices early in their research careers so that they can incorporate new methods and policies to constantly improve their adherence to evolving standards.
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Institutional Career Development Core
  • 批准号:
    10625360
  • 项目类别:
  • 资助金额:
    $91.86万
  • 财政年份:
    2016
  • 负责人:
    Sarah Jane Schlesinger
  • 依托单位:
Institutional Career Development Core
  • 批准号:
    10413257
  • 项目类别:
  • 资助金额:
    $60.9万
  • 财政年份:
    2016
  • 负责人:
    Sarah Jane Schlesinger
  • 依托单位:
A New Anti-CD27 Monoclonal Antibody Adjuvant for Pancreatic Cancer Vaccines
  • 批准号:
    8416332
  • 项目类别:
  • 资助金额:
    $25.43万
  • 财政年份:
    2012
  • 负责人:
    Sarah Jane Schlesinger
  • 依托单位:
A New Anti-CD27 Monoclonal Antibody Adjuvant for Pancreatic Cancer Vaccines
  • 批准号:
    8273920
  • 项目类别:
  • 资助金额:
    $21.19万
  • 财政年份:
    2012
  • 负责人:
    Sarah Jane Schlesinger
  • 依托单位:
海外基金