Generating an Earlier Science of When to Worry: A Neurodevelopmental, Transactional Approach to Characterizing Irritability Patterns Beginning in Infancy

形成关于何时担心的早期科学：一种神经发育、交易方法来表征从婴儿期开始的烦躁模式

• 批准号: 10349344
• 负责人: LAUREN S WAKSCHLAG
• 金额: $ 15.92万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-02 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10349344
• 关键词: Administrative Supplement; Age; Anatomy; Behavioral; Brain; COVID-19; Childhood; Clinical; Communities; Cross-Sectional Studies; Data Collection; Development; Dimensions; Early Intervention; Foundations; Goals; Image; Individual Differences; Infant; Joints; Link; Magnetic Resonance Imaging; Maps; Mental disorders; Nursery Schools; Outcome; Parents; Pattern; Performance; Phase; Phenotype; Prevention; Process; Psychopathology; Regulation; Reporting; Sampling; Science; Shapes; Sleep; Specific qualifier value; Testing; Time; base; clinical predictors; clinical risk; cohort; early childhood; evidence base; executive function; follow-up; high risk; infancy; innovation; population based; vocalization

PROJECT SUMMARY: Irritability emerges during infancy as a substrate of psychopathology. However, reliable identification of irritable infants at high risk for clinical progression is challenging, due to substantial individual differences in adaptive or maladaptive outcomes for irritable infants over time. The When to Worry (W2W) study utilizes a neurodevelopmental framework to generate empirically derived, parameters for differentiation of irritability patterns that mark clinical risk. This administrative supplement request supports completion of the 36 month clinical endpoint and imaging sub-sample assessments, delayed due to COVID-19 disruptions. Key innovations are: (1) specification of developmentally atypical patterns of irritability beginning in infancy; (2) joint developmental consideration of irritability, executive function, and prefrontal cortical regions; and (3) transactional focus. We first conduct a cross-sectional survey of a representative sample of 12-36 mos. olds (N=2,000). We then ascertain an independent community cohort (N=356 infants oversampled for irritability), with longitudinal follow-up (12-36). Irritability assessments are: (a) bimonthly parent reports and real-time irritable vocalizations via the LENA; and (b) annual direct observations of irritability with executive function tasks (12-36 mos.) Performance-based assessments of executive function occur annually. The 36 mo. timepoint is the key clinical endpoint, when preschool psychopathology is well validated. Transactional processes are assessed via parent-infant mutual regulation processes. SPECIFIC AIMS: IA. Differentiate developmentally atypical irritability patterns from infancy-early preschool age via population-based parameters cross-sectionally (IAi) and quantitative longitudinal parameters (IAii). IB. Specify longitudinal parameters of irritability to optimize prediction of clinical progression. IIA-B. Map developmentally atypical irritability patterns to disruptions in the maturation of executive function and prefrontal cortical (PFC) regions and test the hypothesis that their joint consideration will enhance predictive clinical utility. Prefrontal cortical maturation will be assessed from infant natural sleep-MRI at 12 & 36 months (n=50-75). We test whether atypical irritability patterns predict slowed executive function development and abnormal PFC anatomy. IIIA-B. Elucidate how transactional processes shape clinical prediction, testing the hypothesis that parent-infant mutual regulation processes modulate clinical progression. Specification of irritability phenotypes in transactional context is key for prevention. The supplement is key for completing data collection to meet critical objectives of the W2W study.

项目概要：易怒出现在婴儿期，作为精神病理学的基础。然而，在这方面， 可靠地鉴定临床进展高风险的易激惹婴儿是具有挑战性的， 随着时间的推移，易激惹婴儿的适应性或适应不良结果的个体差异。什么时候该担心 (W2W)一项研究利用神经发育框架来生成经验推导的参数， 区分标记临床风险的易怒模式。本行政补充请求支持 完成36个月临床终点和成像子样本评估，因COVID-19而延迟 干扰关键的创新是：（1）规范的发展非典型模式的易怒开始， 婴儿期;（2）对易激惹、执行功能和前额叶皮层区域的联合发育考虑; （3）交易焦点。我们首先对12-36个月的代表性样本进行横断面调查。 奥尔兹（N= 2，000）。然后，我们确定了一个独立的社区队列（N=356名婴儿， 易怒），纵向随访（12-36）。易怒性评估是：（a）每两个月一次的家长报告， 通过LENA的实时易激发声;和（B）执行的易激性的年度直接观察 功能任务（12-36个月）执行功能的绩效评估每年进行一次。36个月。 当学龄前精神病理学得到充分验证时，时间点是关键的临床终点。事务性 过程通过父母-婴儿相互调节过程进行评估。具体目标：IA。区分 从婴儿期到学龄前早期的发育性非典型易怒模式 横截面参数（IAi）和定量纵向参数（IAii）。IB.指定 刺激性的纵向参数，以优化临床进展的预测。IIA-B地图 发育性非典型易怒模式对执行功能成熟的破坏， 前额叶皮层（PFC）区域，并测试假设，他们的联合考虑将提高 预测临床效用。前额叶皮质成熟将从婴儿自然睡眠-MRI在12 & 36个月（n=50-75）。我们测试了非典型的易怒模式是否预示着执行功能的减慢 发育和异常PFC解剖。IIIA-B.阐明事务流程如何塑造临床 预测，测试假设，父母-婴儿相互调节过程调节临床 进展在交易背景下的易怒表型的规范是预防的关键。的 补充是完成数据收集以满足W2 W研究关键目标的关键。

项目成果

Developmental Trajectories of Irritability across the Transition to Toddlerhood: Associations with Effortful Control and Psychopathology.

从幼儿期过渡到易怒的发展轨迹：与努力控制和精神病理学的关联。

• DOI: 10.1007/s10802-023-01098-1
• 发表时间: 2024
• 期刊: Research on child and adolescent psychopathology
• 影响因子: 2.5
• 作者: Zhang,Yudong;MacNeill,LeighaA;Edwards,ReneeC;Burns,JamesL;Zola,AnneR;Poleon,RoshayeB;Nili,AmandaN;Giase,GinaM;Ahrenholtz,RachelM;Wiggins,JillianLee;Norton,ElizabethS;Wakschlag,LaurenS
• 通讯作者: Wakschlag,LaurenS

Modeling the normal:abnormal spectrum of early childhood internalizing behaviors: A clinical-developmental approach for the Multidimensional Assessment Profiles Internalizing Dimensions.

• DOI: 10.1002/mpr.1987
• 发表时间: 2023-11
• 期刊: INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
• 影响因子: 3.1
• 作者: Wakschlag, Lauren S.;Sherlock, Phillip;Blackwell, Courtney K.;Burns, James L.;Krogh-Jespersen, Sheila;Gershon, Richard C.;Cella, David;Buss, Kristin A.;Luby, Joan L.
• 通讯作者: Luby, Joan L.

Drs. Wiggins and Wakschlag Reply.

博士。

• DOI: 10.1016/j.jaac.2020.12.006
• 发表时间: 2021
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Wiggins,JillianLee;Wakschlag,LaurenS
• 通讯作者: Wakschlag,LaurenS

Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.

• DOI: 10.1016/j.neubiorev.2021.07.022
• 发表时间: 2021-10
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: Nielsen AN;Wakschlag LS;Norton ES
• 通讯作者: Norton ES

Developmental patterning of irritability enhances prediction of psychopathology in preadolescence: Improving RDoC with developmental science.

• DOI: 10.1037/abn0000655
• 发表时间: 2022-08
• 期刊: JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
• 作者: Damme, Katherine S F;Norton, Elizabeth S;Briggs-Gowan, Margaret J;Wakschlag, Lauren S;Mittal, Vijay A
• 通讯作者: Mittal, Vijay A