Generating an Earlier Science of When to Worry: A Neurodevelopmental, Transactional Approach to Characterizing Irritability Patterns Beginning in Infancy

形成关于何时担心的早期科学：一种神经发育、交易方法来表征从婴儿期开始的烦躁模式

• 批准号: 10349344
• 负责人: LAUREN S WAKSCHLAG
• 金额: $ 15.92万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-02 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10349344
• 关键词: Administrative Supplement; Age; Anatomy; Behavioral; Brain; COVID-19; Childhood; Clinical; Communities; Cross-Sectional Studies; Data Collection; Development; Dimensions; Early Intervention; Foundations; Goals; Image; Individual Differences; Infant; Joints; Link; Magnetic Resonance Imaging; Maps; Mental disorders; Nursery Schools; Outcome; Parents; Pattern; Performance; Phase; Phenotype; Prevention; Process; Psychopathology; Regulation; Reporting; Sampling; Science; Shapes; Sleep; Specific qualifier value; Testing; Time; base; clinical predictors; clinical risk; cohort; early childhood; evidence base; executive function; follow-up; high risk; infancy; innovation; population based; vocalization

PROJECT SUMMARY: Irritability emerges during infancy as a substrate of psychopathology. However, reliable identification of irritable infants at high risk for clinical progression is challenging, due to substantial individual differences in adaptive or maladaptive outcomes for irritable infants over time. The When to Worry (W2W) study utilizes a neurodevelopmental framework to generate empirically derived, parameters for differentiation of irritability patterns that mark clinical risk. This administrative supplement request supports completion of the 36 month clinical endpoint and imaging sub-sample assessments, delayed due to COVID-19 disruptions. Key innovations are: (1) specification of developmentally atypical patterns of irritability beginning in infancy; (2) joint developmental consideration of irritability, executive function, and prefrontal cortical regions; and (3) transactional focus. We first conduct a cross-sectional survey of a representative sample of 12-36 mos. olds (N=2,000). We then ascertain an independent community cohort (N=356 infants oversampled for irritability), with longitudinal follow-up (12-36). Irritability assessments are: (a) bimonthly parent reports and real-time irritable vocalizations via the LENA; and (b) annual direct observations of irritability with executive function tasks (12-36 mos.) Performance-based assessments of executive function occur annually. The 36 mo. timepoint is the key clinical endpoint, when preschool psychopathology is well validated. Transactional processes are assessed via parent-infant mutual regulation processes. SPECIFIC AIMS: IA. Differentiate developmentally atypical irritability patterns from infancy-early preschool age via population-based parameters cross-sectionally (IAi) and quantitative longitudinal parameters (IAii). IB. Specify longitudinal parameters of irritability to optimize prediction of clinical progression. IIA-B. Map developmentally atypical irritability patterns to disruptions in the maturation of executive function and prefrontal cortical (PFC) regions and test the hypothesis that their joint consideration will enhance predictive clinical utility. Prefrontal cortical maturation will be assessed from infant natural sleep-MRI at 12 & 36 months (n=50-75). We test whether atypical irritability patterns predict slowed executive function development and abnormal PFC anatomy. IIIA-B. Elucidate how transactional processes shape clinical prediction, testing the hypothesis that parent-infant mutual regulation processes modulate clinical progression. Specification of irritability phenotypes in transactional context is key for prevention. The supplement is key for completing data collection to meet critical objectives of the W2W study.

项目摘要：在婴儿期作为心理病理学的底物出现烦恼。然而， 由于实质性的 随着时间的流逝，易激的婴儿的适应性或适应不良结果的个体差异。何时担心 （W2W）研究利用神经发育框架来生成经验得出的参数 标志着临床风险的易怒模式的区分。此行政补充请求支持 完成为36个月的临床终点和成像子样本评估，延迟了COVID-19 干扰。关键创新是：（1）从发育开发的非典型模式的规范。 婴儿期； （2）共同考虑烦躁，执行功能和前额叶皮质区域的共同发展； （3）交易重点。我们首先对12-36 MO的代表性样本进行了横断面调查。 老板（n = 2,000）。然后，我们确定一个独立的社区队列（n = 356名婴儿 烦恼），纵向随访（12-36）。烦躁的评估是：（a）双月父母报告和 通过Lena进行实时易怒的发声； （b）每年直接观察到执行 功能任务（12-36个月）每年都会进行基于绩效的执行功能评估。 36 mo。 当学龄前心理病理学得到充分验证时，时间点是关键的临床终点。交易 通过父母的共同调节过程评估过程。具体目的：ia。区分 从婴儿期到基于人群的学龄前年龄的发育上的非典型易怒模式 参数横截面（IAI）和定量纵向参数（IAII）。 IB。指定 纵向参数是易怒的，以优化临床进展的预测。 iia-b。地图 发育中非典型的易怒模式，使执行功能成熟和 前额叶皮质（PFC）区域，并检验其联合考虑将增强的假设 预测性临床实用程序。前额叶皮质成熟将从婴儿自然睡眠中心进行12时评估 36个月（n = 50-75）。我们测试非典型的烦躁模式是否可以预测执行功能放缓 发育和异常PFC解剖结构。 IIIA-B。阐明交易过程如何塑造临床 预测，检验父母共同调节过程调节临床的假设 进展。在交易背景下的易怒表型的规范是预防的关键。这 补充是完成数据收集以满足W2W研究的关键目标的关键。

项目成果

Developmental Trajectories of Irritability across the Transition to Toddlerhood: Associations with Effortful Control and Psychopathology.

从幼儿期过渡到易怒的发展轨迹：与努力控制和精神病理学的关联。

• DOI: 10.1007/s10802-023-01098-1
• 发表时间: 2024
• 期刊: Research on child and adolescent psychopathology
• 影响因子: 2.5
• 作者: Zhang,Yudong;MacNeill,LeighaA;Edwards,ReneeC;Burns,JamesL;Zola,AnneR;Poleon,RoshayeB;Nili,AmandaN;Giase,GinaM;Ahrenholtz,RachelM;Wiggins,JillianLee;Norton,ElizabethS;Wakschlag,LaurenS
• 通讯作者: Wakschlag,LaurenS

Drs. Wiggins and Wakschlag Reply.

博士。

• DOI: 10.1016/j.jaac.2020.12.006
• 发表时间: 2021
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Wiggins,JillianLee;Wakschlag,LaurenS
• 通讯作者: Wakschlag,LaurenS

Modeling the normal:abnormal spectrum of early childhood internalizing behaviors: A clinical-developmental approach for the Multidimensional Assessment Profiles Internalizing Dimensions.

• DOI: 10.1002/mpr.1987
• 发表时间: 2023-11
• 期刊: INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
• 影响因子: 3.1
• 作者: Wakschlag, Lauren S.;Sherlock, Phillip;Blackwell, Courtney K.;Burns, James L.;Krogh-Jespersen, Sheila;Gershon, Richard C.;Cella, David;Buss, Kristin A.;Luby, Joan L.
• 通讯作者: Luby, Joan L.

Developmental patterning of irritability enhances prediction of psychopathology in preadolescence: Improving RDoC with developmental science.

• DOI: 10.1037/abn0000655
• 发表时间: 2022-08
• 期刊: JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
• 作者: Damme, Katherine S F;Norton, Elizabeth S;Briggs-Gowan, Margaret J;Wakschlag, Lauren S;Mittal, Vijay A
• 通讯作者: Mittal, Vijay A

Calibrating temper loss severity in the transition to toddlerhood: Implications for developmental science.

• DOI: 10.1080/10888691.2021.1995386
• 发表时间: 2022
• 期刊: APPLIED DEVELOPMENTAL SCIENCE
• 影响因子: 3.8
• 作者: Krogh-Jespersen, Sheila;Kaat, Aaron J.;Petitclerc, Amelie;Perlman, Susan B.;Briggs-Gowan, Margaret J.;Burns, James L.;Adam, Hubert;Nili, Amanda;Gray, Larry;Wakschlag, Lauren S.
• 通讯作者: Wakschlag, Lauren S.