Alliance NCORP Research Base - BIQSFP Supplements

联系PD/PI：Bertagnolli，Monica M. 项目总结/摘要 肿瘤临床试验联盟（Alliance for Clinical Trials in Oncology）是五个国家临床试验网络组织之一， 作为联盟NCI社区肿瘤学研究计划（NCORP）研究的母组织 基地（Alliance NCORP）。联盟NCORP进行干预性和观察性临床研究， 转化研究以及数据库研究-所有这些都解决了与癌症相关的重要问题 预防、症状控制和癌症护理提供。此外，联盟NCORP进行临床 重要的生活质量研究，嵌入在癌症治疗试验中。它特别强调 少数人，服务不足和老年患者有患癌症的风险或被诊断患有癌症，并建立强大的大学 与NCORP社区站点和少数民族/服务不足社区站点的关系。联盟NCORP 委员会成员包括来自社区和学术医疗中心的丰富代表， 以及患者倡导者，从而产生与美国癌症患者相关的研究结果。 States.该联盟还强调对初级调查员的辅导和培训。过去一 授权周期，即，自2014年8月以来，联盟NCORP已发表了240多篇手稿和摘要。 这项工作包括在预防化疗引起的肿瘤等领域改变实践的研究。 恶心和呕吐，预防骨转移瘤相关事件， 脑转移，以及将患者报告的结果整合到癌症临床试验中。联盟 NCORP进行转化研究，需要收集肿瘤组织，癌前组织 样本、血液和其他人类生物标本;并共享数据和生物标本，用于合并分析， 其他科学合作。这些生物标本为了解临床 从机械的角度来看。联盟NCORP还与其他NCI广泛合作- 资助的调查人员和财团，以及通过非NCI来源支持的调查人员。这 改变实践的研究和联盟NCORP回答的科学问题提供了有意义的 和创新的贡献，临床和转化肿瘤学，这只能在一个公开的， 资助的研究网络。

Contact PD/PI: Bertagnolli, Monica M. PROJECT SUMMARY/ABSTRACT The Alliance for Clinical Trials in Oncology (Alliance), one of five National Clinical Trials Network groups, serves as the parent organization for the Alliance NCI Community Oncology Research Program (NCORP) Research Base (Alliance NCORP). The Alliance NCORP conducts interventional and observational clinical and translational research as well as database studies – all of which address important questions relevant to cancer prevention, symptom control, and cancer care delivery. In addition, the Alliance NCORP conducts clinically important quality of life studies that are embedded within cancer treatment trials. It places special emphasis on minority, underserved and older patients at risk for or diagnosed with cancer, and on building strong collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance NCORP committee membership includes rich representation from both community-based and academic medical centers, as well as patient advocates, thus generating research results relevant to cancer patients across the United States. The Alliance NCORP also emphasizes mentorship and training of junior investigators. Over this past grant cycle, i.e., since August 2014, the Alliance NCORP has published over 240 manuscripts and abstracts. This work has included practice-changing research in such areas as the prevention of chemotherapy-induced nausea and vomiting, the prevention of skeletal-related events from osseous metastases, the management of brain metastases, and the integration of patient-reported outcomes into cancer clinical trials. The Alliance NCORP conducts translational research that requires the collection of tumor tissue, premalignant tissue samples, blood, and other human biospecimens; and shares data and biospecimens for pooled analyses and other scientific collaborations. These biospecimens create an invaluable repository for understanding clinical observations from a mechanistic standpoint. The Alliance NCORP also collaborates broadly with other NCI- funded investigators and consortia, as well as with investigators supported through non-NCI sources. This practice-changing research and the scientific questions answered by the Alliance NCORP provide meaningful and innovative contributions to clinical and translational oncology, which can be conducted only within a publicly- funded research network.