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Epidemiology of Biomarkers of AMD Progression

AMD 进展生物标志物的流行病学

基本信息

批准号：
10489288
负责人：
Jonathan L Haines
金额：
$ 58.26万
依托单位：
DOHENY EYE INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10489288
关键词：
Address Age Age Years Age related macular degeneration Amish Angiogenesis Inhibitors Angiography Atrophic Background Diabetic Retinopathy Biological Markers Blindness Calibration Choroid Choroidal Neovascularization Classification Clinic Clinical Clinical Research Clinical Trials Color Data Deposition Development Diabetic Retinopathy Disease Drusen Early Intervention Elderly Epidemiology Evolution Eye Eye diseases Film Functional disorder Funding Fundus Genetic Genetic Markers Genetic Variation Image Imaging technology Individual Intervention Intervention Trial Knowledge Methods Modeling Modernization Multimodal Imaging Nonexudative age-related macular degeneration Optical Coherence Tomography Outcome Assessment Patients Phase Phenotype Population Population Study Principal Component Analysis Probability Protocols documentation Research Research Personnel Resources Retina Risk Risk Factors Series Severities Severity of illness Staging Staging System System Techniques Testing Therapeutic Trials Time Uncertainty United States Validation Visit age related clinical practice cohort cost deep learning design digital imaging effective therapy effectiveness evaluation epidemiology study follow-up genetic risk factor geographic atrophy high risk improved insight learning algorithm macula neovascularization novel population based prevent progression risk recruit risk variant social statistical learning success therapy development three-dimensional visualization

项目摘要

Project Abstract There are currently no effective treatments for atrophic age-related macular degeneration (AMD), in part because we may be intervening too late in the disease course after geographic atrophy (GA) has developed. A far preferable strategy would be to intervene at an earlier phase of the disease, but there is uncertainty with regards to disease biomarkers to select the most appropriate patients as well as endpoints which could be used to conduct an interventional trial in a clinically-practical time-frame. This is in large part because of the lack of a sufficiently granular staging system describing the progression from early to late stage AMD. The best currently available data comes from studies such as the Age-Related Eye Diseases Study and the Beaver Dam Eye Study, but these studies were largely based on color fundus photographs with AMD disease features assessed using historical protocols developed in the film-based imaging era. The AMD disease severity scales and staging systems built from these studies are insufficiently granular and fail to take advantage of modern, pervasive digital imaging technologies such as optical coherence tomography (OCT) and OCT angiography (OCT-A) which readily lend themselves to quantification. Extensive research over the past decade has identified a number of structural OCT features of AMD, such as intraretinal hyper-reflective foci and subretinal drusenoid deposits, which appear to increase the risk for developing late AMD (atrophy and/or neovascularization). More recently, choriocapillaris (CC) flow deficits have been shown to increase with age and in AMD. The relationship between CC flow deficits and the onset and stage of AMD still remains to be defined. In addition, although a number of genetic risk factors for AMD have been identified, the genetics of AMD progression are not yet elucidated. This research application proposes to address these critical knowledge gaps by evaluating elderly subjects with AMD who have previously been recruited as part of the NEI-funded Amish Eye Study. The Amish represent a homogenous population with regards to environmental and social exposures which reduces variability and makes this group ideally suited for epidemiologic studies of AMD progression. Through that previous study, baseline (and some 2-year follow up) clinical, multimodal imaging (including OCT), and genetic data have already been collected. However, long-term (7 year) data, which will be a focus of our proposed research, is critical to actually establish which individuals go on to progress to late AMD, which is vital in order to determine which baseline features are associated with a higher risk of progression, and to develop a granular and quantitative staging system for AMD. The development of this novel AMD staging system will provide points of intervention and outcome assessment to enable early intervention clinical trials and provide new insights into the genetics and pathophysiology of AMD.

项目摘要

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of OCT B-Scan Density on Sensitivity for Detection of Intraretinal Hyperreflective Foci in Eyes with Age-Related Macular Degeneration.

DOI：
10.1080/02713683.2022.2081981
发表时间：
2022-09
期刊：
Current eye research
影响因子：
2
作者：
通讯作者：

Longitudinal evaluation of the distribution of intraretinal hyper-reflective foci in eyes with intermediate age-related macular degeneration.

中度年龄相关性黄斑变性眼视网膜内高反射灶分布的纵向评估。

DOI：
10.21203/rs.3.rs-3273570/v1
发表时间：
2023
期刊：
Research square
影响因子：
0
作者：
Sadda,Srinivas;Verma,Aditya;Corradetti,Giulia;Nittala,Muneeswar;He,Ye;Nassisi,Marco;Velaga,SwethaBindu;Haines,Jonathan;Pericak-Vance,Margaret;Stambolian,Dwight
通讯作者：
Stambolian,Dwight

Enhanced Detection of Reticular Pseudodrusen on Color Fundus Photos by Image Embossing.

DOI：
10.1080/02713683.2022.2126860
发表时间：
2022-11
期刊：
Current eye research
影响因子：
2
作者：
通讯作者：

Drusen morphometrics on optical coherence tomography in eyes with age-related macular degeneration and normal aging.

DOI：
10.1007/s00417-023-06088-z
发表时间：
2023-09
期刊：
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
影响因子：
2.7
作者：
Oncel, Deniz;Corradetti, Giulia;Wakatsuki, Yu;Nittala, Muneeswar Gupta;Velaga, Swetha Bindu;Stambolian, Dwight;Pericak-Vance, Margaret A.;Haines, Jonathan L.;Sadda, SriniVas R.
通讯作者：
Sadda, SriniVas R.

Risk Factors for Progression of Age-Related Macular Degeneration: Population-Based Amish Eye Study.