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Greater Caribbean Center for Ciguatera Research

大加勒比雪卡研究中心

基本信息

批准号：
10443681
负责人：
Michael Parsons
金额：
$ 45.88万
依托单位：
FLORIDA GULF COAST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10443681
关键词：
Abdominal Pain Affect Alabama Bradycardia Caribbean region Cell Wall Cells Cellular biology Ciguatera Poisoning Ciguatoxins Communities Consumption Coupled Detection Development Diagnosis Diarrhea Dinophyceae Disease Disease Outbreaks Dysesthesias Educational Activities Event Exposure to Fisheries Fishes Florida Flowers Food Webs Frequencies Future Gambierdiscus Geography Goals Growth High temperature of physical object Hypotension Institution Ion Channel Gating Island Laboratories Link Lipids Louisiana Malignant Neoplasms Measures Medical Membrane Metabolic Biotransformation Metabolism Mexico Molecular Movement Muscle Myalgia Nature Nausea Nerve Nerve Tissue Neurologic Signs Neurologic Symptoms Neurotoxins Oceanography Output Permeability Persons Physiological Play Prevention Process Production Pruritus Public Health Recreation Research Research Project Grants Rest Risk Role Science Scientist Sea Seafood Secure Stress Surface Symptoms Temperature Testing Tetrodotoxin Texas Toxic effect Toxin Translating United States United States Virgin Islands Universities Vomiting Vulnerable Populations Water Work bioaccumulation climate change community engagement contaminated fish coral economic impact experience exposed human population gastrointestinal symptom genotoxicity gulf coast marine mortality neuronal excitability novel organizational structure response seafood poisoning sodium ion synergism toxic algae voltage

项目摘要

Ciguatera fish poisoning (CFP) is the most common form of phycotoxin-borne seafood illness across the globe, affecting tens of thousands of people annually. CFP is caused by the consumption of seafood (primarily reef fish) contaminated with ciguatoxins. Gambiertoxins, precursors of ciguatoxins produced by the (sub)tropical benthic dinoflagellate genus Gambierdiscus, enter reef food webs when herbivores and detritivores consume Gambierdiscus directly or indirectly by grazing on macroalgae. These precursor molecules are transferred to higher trophic levels by bioaccumulation, bioconversion and biomagnification until they reach predatory finfish species that are targeted in many commercial and recreational fisheries. When people subsequently consume the contaminated fish, they are exposed to the toxins, thereby experiencing CFP. Historically, CFP outbreaks have been linked with warm water temperatures and coral reef impacts, both of which are expected to increase in the setting of climate change. Consequently, CFP is predicted to increase on geographic and temporal scales. For example, although CFP is endemic to the Caribbean, the Florida Keys, and South Florida, CFP appears to be expanding northwards into the Gulf of Mexico, highlighted by the recent identification of toxic fish in the Flower Garden Marine Sanctuary off of the Texas/Louisiana coast. Ciguatoxin is a novel type of voltage-gated ion channel toxin. In nerve tissues, ciguatoxin causes a tetrodotoxin-sensitive increase in sodium ion permeability and depolarization of the resting membrane. Depending on the magnitude of the depolarization, the consequence can be an increase in excitability of the neuronal membrane or a depolarizing type of conduction block at high concentrations. The onset of CFP is typically characterized by gastrointestinal and neurological symptoms and signs typically persist for days to weeks, with vomiting, diarrhea, nausea, abdominal pain, dysesthesia, pruritus, myalgia being common. Severe cases of ciguatera may involve hypotension and bradycardia, but fatalities are rare. Occasionally, neurological signs may persist for several months. Remarkably, the diagnosis of ciguatera is still largely dependent on the astuteness of the clinician. In the absence of a confirmatory laboratory test, a sizable proportion of cases still go undiagnosed and unreported. The enigmatic nature of CFP events, coupled with a lack of sustained scientific research on the environmental and physiological factors that contribute to outbreaks, has hindered progress in the development of management strategies to protect people against exposure to ciguatoxins. The purpose of this project, therefore, is to establish a Greater Caribbean Center for Ciguatera Research to 1) examine the role climate change may play in the geographic and temporal expansion of CFP into more temperate latitudes; 2) obtain a better understanding of the toxic metabolites produced by certain Gambierdiscus strains, and the subsequent transfer and biotransformation of these compounds into coastal/reef food webs; and 3) study the genotoxicity and impacts on cellular metabolism caused by these toxins upon exposure.

雪卡水鱼中毒（CFP）是全球最常见的藻毒素引起的海产品疾病，