权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Histology, Biomechanics, and Human Tissue Core

组织学、生物力学和人体组织核心

基本信息

批准号：
10495744
负责人：
Jinhu Xiong
金额：
$ 22.06万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-16 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10495744
关键词：
Animals Arkansas Bioinformatics Biology Biomechanics Bone Marrow Bone Marrow Cells Bone Tissue Clinical Clinical Data Collaborations DNA Decalcification Disease Doctor of Philosophy Educational Activities Educational workshop Endocrinology Ensure Equipment Faculty Frozen Sections Gene Expression Genetic Goals Hindlimb Suspension Hip region structure Histologic Histology Human Human Resources Image In Situ Institution Knowledge Laboratories Maintenance Measurement Medical Mesenchymal Stem Cells Metastatic Neoplasm to the Bone Microtomy Molecular Mus Musculoskeletal Musculoskeletal Diseases Operative Surgical Procedures Orthopedics Osteogenesis Osteoporosis Paraffin Embedding Pathologic Patient Care Patients Phase Physiological Plasma Plastic Embedding Process RNA Research Research Infrastructure Research Personnel Research Project Grants Resources Sampling Science Serum Services Skeleton Stains System Testing Thick Tissue Sample Tissues Training Training and Education Translational Research Universities Urine Work biobank biomechanical test bone bone imaging design experience experimental study hip replacement arthroplasty human tissue in vivo investigator training long bone member mouse model new technology novel programs research faculty skeletal skeletal disorder spine bone structure success tibia transcriptomics

项目摘要

PROJECT SUMMARY/ABSTRACT – CORE C The goal of the Histology, Biomechanics, and Human Tissue Core (Core C) is to provide state-of-the-art services for the characterization of tissue and cellular changes that underlie the pathological mechanisms of skeletal diseases in both mice and humans. The core will provide 3 services: 1) high quality and reliable hard- tissue histology services that will help investigators identify the cellular basis of musculoskeletal changes and formulate new mechanistic hypotheses for disease processes; 2) comprehensive in vivo and ex vivo biomechanical testing to quantify the mechano-responsiveness, quality, and strength of the skeleton under physiological and pathological conditions; and 3) banking and access to human tissue samples from hip replacement surgeries and bone marrow cells with their associated clinical data from patients with various conditions. This is a novel component that will expand the translational research opportunities in the Center for Musculoskeletal Disease Research (CMDR) for Project Leaders, CMDR faculty, and eventually additional researchers at the University of Arkansas for Medical Sciences (UAMS) and affiliated institutions. The core will be essential to accomplish the goals of each Phase 2 research project. Core C will extensively interact with the other cores of the CMDR by providing histological and biomechanical analysis for new mouse models created by the Genetic Mouse Model Core (Core B), working with the Bone Imaging Core (Core D) for biomechanical analysis and providing samples for histomorphometric analysis, and collaborating with the Bioinformatics Core (Core E) for developing spatial transcriptomics. Overall, the Histology, Biomechanics, and Human Tissue Core provides unique and essential services and thereby significantly expands the musculoskeletal research infrastructure at UAMS and its affiliates.

项目摘要/摘要-核心c