Histology, Biomechanics, and Human Tissue Core
组织学、生物力学和人体组织核心
基本信息
- 批准号:10495744
- 负责人:
- 金额:$ 22.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-02-16 至 2028-01-31
- 项目状态:未结题
- 来源:
- 关键词:AnimalsArkansasBioinformaticsBiologyBiomechanicsBone MarrowBone Marrow CellsBone TissueClinicalClinical DataCollaborationsDNADecalcificationDiseaseDoctor of PhilosophyEducational ActivitiesEducational workshopEndocrinologyEnsureEquipmentFacultyFrozen SectionsGene ExpressionGeneticGoalsHindlimb SuspensionHip region structureHistologicHistologyHumanHuman ResourcesImageIn SituInstitutionKnowledgeLaboratoriesMaintenanceMeasurementMedicalMesenchymal Stem CellsMetastatic Neoplasm to the BoneMicrotomyMolecularMusMusculoskeletalMusculoskeletal DiseasesOperative Surgical ProceduresOrthopedicsOsteogenesisOsteoporosisParaffin EmbeddingPathologicPatient CarePatientsPhasePhysiologicalPlasmaPlastic EmbeddingProcessRNAResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesSamplingScienceSerumServicesSkeletonStainsSystemTestingThickTissue SampleTissuesTrainingTraining and EducationTranslational ResearchUniversitiesUrineWorkbiobankbiomechanical testbonebone imagingdesignexperienceexperimental studyhip replacement arthroplastyhuman tissuein vivoinvestigator traininglong bonemembermouse modelnew technologynovelprogramsresearch facultyskeletalskeletal disorderspine bone structuresuccesstibiatranscriptomics
项目摘要
PROJECT SUMMARY/ABSTRACT – CORE C
The goal of the Histology, Biomechanics, and Human Tissue Core (Core C) is to provide state-of-the-art
services for the characterization of tissue and cellular changes that underlie the pathological mechanisms of
skeletal diseases in both mice and humans. The core will provide 3 services: 1) high quality and reliable hard-
tissue histology services that will help investigators identify the cellular basis of musculoskeletal changes and
formulate new mechanistic hypotheses for disease processes; 2) comprehensive in vivo and ex vivo
biomechanical testing to quantify the mechano-responsiveness, quality, and strength of the skeleton under
physiological and pathological conditions; and 3) banking and access to human tissue samples from hip
replacement surgeries and bone marrow cells with their associated clinical data from patients with various
conditions. This is a novel component that will expand the translational research opportunities in the Center for
Musculoskeletal Disease Research (CMDR) for Project Leaders, CMDR faculty, and eventually additional
researchers at the University of Arkansas for Medical Sciences (UAMS) and affiliated institutions. The core will
be essential to accomplish the goals of each Phase 2 research project. Core C will extensively interact with the
other cores of the CMDR by providing histological and biomechanical analysis for new mouse models created
by the Genetic Mouse Model Core (Core B), working with the Bone Imaging Core (Core D) for biomechanical
analysis and providing samples for histomorphometric analysis, and collaborating with the Bioinformatics Core
(Core E) for developing spatial transcriptomics. Overall, the Histology, Biomechanics, and Human Tissue Core
provides unique and essential services and thereby significantly expands the musculoskeletal research
infrastructure at UAMS and its affiliates.
项目摘要/摘要-核心c
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jinhu Xiong其他文献
Jinhu Xiong的其他文献
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{{ truncateString('Jinhu Xiong', 18)}}的其他基金
The role of Piezo1 in bone homeostasis and mechanotransduction
Piezo1 在骨稳态和力传导中的作用
- 批准号:
10642770 - 财政年份:2020
- 资助金额:
$ 22.06万 - 项目类别:
The role of Piezo1 in bone homeostasis and mechanotransduction
Piezo1 在骨稳态和力传导中的作用
- 批准号:
10418767 - 财政年份:2020
- 资助金额:
$ 22.06万 - 项目类别:
The role of Piezo1 in bone homeostasis and mechanotransduction
Piezo1 在骨稳态和力传导中的作用
- 批准号:
10238777 - 财政年份:2020
- 资助金额:
$ 22.06万 - 项目类别:
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