Mentored Clinical Scientist Research Career Development Award

指导临床科学家研究职业发展奖

• 批准号: 9517094
• 负责人: Alexander M Friedman
• 金额: $ 16.61万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9517094
• 关键词: Adherence; Agreement; Antibiotics; Area; Biometry; Birth; Caring; Cesarean section; Characteristics; Childbirth; Clinical; Clinical Research; Clinical Trials; Complex; Coronary Artery Bypass; Data; Data Set; Development; Discipline of obstetrics; Epidemiologist; Epidemiology; Faculty; Fetal Distress; Fetal Heart Rate; Foundations; Goals; Gynecologic Oncologist; Health; Health Services Research; Healthcare; Hospitals; Human; Individual; Induced Labor; International; Intervention; Journals; K-Series Research Career Programs; Knowledge; Lead; Leadership; Measurement; Measures; Mechanics; Medical; Mentors; Mentorship; Methodology; Modeling; Morbidity - disease rate; Myocardial Infarction; Neonatal; Operative Surgical Procedures; Outcome; Outcomes Research; Patients; Performance; Perinatal; Physicians; Pneumonia; Population Research; Process Measure; Prophylactic treatment; Prostaglandins; Provider; Quality of Care; Recommendation; Reporting; Reproduction; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Risk Reduction; Scientist; Source; Statistical Methods; Streptococcus Group B; System; Thromboembolism; Time; Training; Trial of Labor; Vaginal delivery procedure; Variant; Venous; Woman; Work; adverse outcome; base; clinically relevant; comparative effectiveness; effectiveness research; experience; high risk; improved; innovation; intrapartum; lectures; mortality; neonatal outcome; novel; population based; preference; public health relevance; randomized trial; skills; symposium; translational scientist

 DESCRIPTION (provided by applicant): The purpose of this application for a Mentored Clinical Scientist Research Career Development Award (K08) is to allow the applicant sufficient protected time to 1) develop the statistical and methodological skills necessary to perform high quality health services research, 2) develop additional skills in study design and implementation, and 3) further develop leadership and management skills to lead a productive research team. In the long term, Dr. Friedman hopes to: 1) identify areas of sub-optimal care and health care variation using administrative datasets and data from large clinical trials, 2) identify optimal cae improvement strategies within the context of comparative effectiveness research, and 3) perform clinical research to assess the validity and benefit of quality improvement initiatives. Specifically, Dr. Friedman's plan includes a focus on developing an expertise in causal inference methodology, a framework of analysis that will allow him uniquely poised to perform high-impact research in his field. Through formal biostatistical training, active participation in analysis of complex datasets, close mentorship by Dr. Cande Ananth and Dr. Jason Wright, attending lectures, journal clubs, conferences, and symposia, and performing the research analysis evaluating intrapartum care quality outlined in the application, Dr. Friedman hopes to substantially enhance his capabilities as a researcher. Dr. Friedman has identified Dr. Wright and Dr. Ananth because of their expertise in epidemiology, biostatistics, and health outcomes research as well as their long track record of successfully mentoring junior faculty. Dr. Ananth is an internationally renowned perinatal epidemiologist whose research work focuses on developing and applying innovative statistical approaches to studies in human reproduction. Dr. Jason Wright is a gynecologic oncologist, experienced clinical trialist, translational researcher, and epidemiologist. Dr. Wright and Dr. Ananth are both committed to working closely with Dr. Friedman. With increased knowledge of the complexities of biostatistics and research methodology, Dr. Friedman will gain the ability to independently perform high-quality health outcomes research. He has identified a senior advisory panel to oversee his progress and will meet quarterly with this group. The research strategy for this application is a novel population-based care quality study evaluating candidate measures for quality of intrapartum care. To summarize the study, Dr. Friedman notes that little is known about baseline adherence to obstetric practices that may be representative of care quality during labor and childbirth and how physician, provider, and patient factors influence adherence. Given that there is no agreement on how to best measure the quality of obstetric care, valid measures of intrapartum care quality are urgently needed. With his excellent mentorship team, Dr. Friedman's research plan may result in clinically relevant and useful findings that improve maternal care.

 描述（由申请人提供）：申请指导临床科学家研究职业发展奖（K08）的目的是让申请人有足够的保护时间来 1) 培养进行高质量卫生服务研究所需的统计和方法技能，2) 培养研究设计和实施方面的额外技能，以及 3) 进一步培养领导和管理技能，以领导一个富有成效的研究团队。从长远来看，Friedman 博士希望：1) 使用管理数据集和大型临床试验的数据来确定次优护理和医疗保健变化的领域，2) 在比较有效性研究的背景下确定最佳的 cae 改进策略，3) 进行临床研究以评估质量改进举措的有效性和益处。具体来说，弗里德曼博士的计划包括重点发展因果推理方法方面的专业知识，这是一种分析框架，使他能够在自己的领域中进行高影响力的研究。通过正式的生物统计培训、积极参与复杂数据集的分析、Cande Ananth 博士和 Jason Wright 博士的密切指导、参加讲座、期刊俱乐部、会议和研讨会，以及进行评估申请中概述的产时护理质量的研究分析，Friedman 博士希望能够大幅提高他作为研究人员的能力。弗里德曼博士之所以选中 Wright 博士和 Ananth 博士，是因为他们在流行病学、生物统计学和健康结果研究方面的专业知识，以及他们在指导初级教师方面的长期成功记录。阿南特博士是 国际知名的围产期流行病学家，其研究工作重点是开发和应用创新的统计方法来研究人类生殖。 Jason Wright 博士是一位妇科肿瘤学家、经验丰富的临床试验师、转化研究员和流行病学家。 Wright 博士和 Ananth 博士都致力于与 Friedman 博士密切合作。随着对生物统计学和研究方法的复杂性了解的增加，弗里德曼博士将获得独立进行高质量健康结果研究的能力。他已经任命了一个高级顾问小组来监督他的进展，并将每季度与该小组会面。该应用程序的研究策略是一项新颖的基于人群的护理质量研究，评估产时护理质量的候选指标。弗里德曼博士总结了这项研究，指出人们对产科实践的基线依从性知之甚少，这些基线可能代表临产和分娩期间的护理质量，以及医生、提供者和患者因素如何影响依从性。鉴于如何最好地衡量产科护理质量尚未达成一致，因此迫切需要有效的产时护理质量衡量标准。凭借其优秀的指导团队，弗里德曼博士的研究计划可能会产生临床相关且有用的发现，从而改善孕产妇护理。

项目成果

Maternal Outcomes by Race for Women Aged 40 Years or Older.

40 岁或以上女性按种族划分的产妇结果。

• DOI: 10.1097/aog.0000000000002751
• 发表时间: 2018
• 期刊: Obstetrics and gynecology
• 影响因子: 7.2
• 作者: Booker,WhitneyA;Gyamfi-Bannerman,Cynthia;Sheen,Jean-Ju;Wright,JasonD;Siddiq,Zainab;D'Alton,MaryE;Friedman,AlexanderM
• 通讯作者: Friedman,AlexanderM

Hospital delivery volume, severe obstetrical morbidity, and failure to rescue.

• DOI: 10.1016/j.ajog.2016.07.039
• 发表时间: 2016-12
• 期刊: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
• 影响因子: 9.8
• 作者: Friedman, Alexander M.;Ananth, Cande V.;Huang, Yongmei;D'Alton, Mary E.;Wright, Jason D.
• 通讯作者: Wright, Jason D.

Fragmentation of postoperative care after surgical management of ovarian cancer at 30 days and 90 days.

卵巢癌手术治疗后 30 天和 90 天的术后护理的碎片化。

• DOI: 10.1016/j.ajog.2019.09.005
• 发表时间: 2020
• 期刊: American journal of obstetrics and gynecology
• 影响因子: 9.8
• 作者: Cham,Stephanie;Wen,Timothy;Friedman,Alexander;Wright,JasonD
• 通讯作者: Wright,JasonD

Postpartum readmissions among women with opioid use disorder.

患有阿片类药物使用障碍的女性产后再入院。

• DOI: 10.1016/j.ajogmf.2019.02.004
• 发表时间: 2019
• 期刊: American journal of obstetrics & gynecology MFM
• 影响因子: 6.3
• 作者: Wen,Timothy;Batista,Naralys;Wright,JasonD;D'Alton,MaryE;Attenello,FrankJ;Mack,WilliamJ;Friedman,AlexanderM
• 通讯作者: Friedman,AlexanderM

Oral Opioid Use during Vaginal Delivery Hospitalizations.

阴道分娩住院期间口服阿片类药物的使用。

• DOI: 10.1055/s-0039-1678566
• 发表时间: 2020
• 期刊: American journal of perinatology
• 影响因子: 2
• 作者: Mourad,Mirella;Landau,Ruth;Wright,JasonD;Siddiq,Zainab;Duffy,CassandraR;Kern-Goldberger,AdinaR;D'Alton,MaryE;Friedman,AlexanderM
• 通讯作者: Friedman,AlexanderM