Cancer Epidemiology Research Program (CE) (Project-008)

癌症流行病学研究计划 (CE)（项目-008）

• 批准号: 9553536
• 负责人: Wei Zheng
• 金额: $ 9.19万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9553536
• 关键词: Advisory Committees; Affect; American Cancer Society; Area; Award; Basic Science; Biological Markers; Breast Cancer survivor; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Etiology; Cancer Patient; Cancer Prognosis; Case-Control Studies; Catchment Area; Chemoprevention; Clinical Research; Clinical Sciences; Cohort Studies; Collaborations; Country; Data; Development; Doctor of Philosophy; Early Diagnosis; Educational workshop; Environment; Environmental Risk Factor; Epidemiology; Etiology; Faculty Recruitment; Fostering; Funding; Genetic; Goals; Grant; Growth; Guidelines; Institution; International; Investigation; Joints; Journals; Knowledge; Laboratories; Leadership; Life Style; Malignant Neoplasms; Mentors; Methodology; Mission; Modification; Molecular Epidemiology; Molecular Epidemiology of Cancer; Morbidity - disease rate; Participant; Peer Review; Play; Population; Population Research; Populations at Risk; Postdoctoral Fellow; Prevention; Prevention strategy; Prognostic Factor; Program Research Project Grants; Publications; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Risk Assessment; Role; Schools; Scientist; Technology; Testing; Training; Training Programs; Underrepresented Groups; United States; United States National Institutes of Health; Women' s Health; anticancer research; base; cancer biomarkers; cancer epidemiology; cancer genetics; cancer prevention; cancer research center director; cancer risk; cancer survival; career development; design; editorial; epidemiology study; experience; genetic epidemiology; global health; health disparity; improved; lifestyle factors; medical schools; member; mortality; next generation; nutrition; nutritional epidemiology; population based; professor; programs; success; tumor progression

PROJECT 008 – CANCER EPIDEMIOLOGY RESEARCH PROGRAM PROJECT SUMMARY/ABSTRACT With a significant growth in population-based research at the Vanderbilt-Ingram Cancer Center (VICC), the original Cancer Epidemiology, Prevention and Control program is now divided into two more focused programs. The newly formed Cancer Epidemiology (CE) Research Program, directed by Wei Zheng, MD, PhD and Xiao-Ou Shu, MD, PhD, seeks to conduct high-impact research to improve understanding of the etiology and genetics of cancer and identify biomarkers for cancer risk and prognosis to inform the development of effective cancer prevention strategies. The CE program is broadly organized into four main cancer research thematic areas: 1) molecular and genetic epidemiology; 2) epidemiology of nutrition, lifestyle and environmental factors for cancer risk; 3) investigation of prognostic factors for cancer survival; and 4) international studies and health disparities research. One of the key CE strengths lies in the establishment and conduct of large cohort studies with extensive exposure data and biospecimens obtained from 223,000 study participants. CE members are also conducting large cancer case-control studies. These resources provide exceptional population-based field laboratories for many significant investigations. CE members are at the forefront of identifying genetic and lifestyle factors and biomarkers for multiple cancers, with research significantly advancing knowledge of cancer etiology and genetics, contributing to the modification of American Cancer Society’s lifestyle guidelines for breast cancer survivors, and launching two chemoprevention trials. The research is directly relevant to the VICC catchment area, involving participation by multiple segments of this population, including historically underrepresented groups. CE also has a large portfolio of international research to test scientific hypotheses that cannot be adequately investigated in U.S.-based studies and plays a leadership role in multiple large cancer epidemiology consortia. CE hosts three NIH-funded training programs and has successfully fostered the career development of multiple junior investigators. There are 26 program members from five departments and two schools with $11.0 M in NCI funding and $1.5M in other peer-reviewed cancer-related funding. Out of 421 publications, 58% are intra-programmatic and 63% are inter-programmatic. Members also have 181 collaborative publications with investigators at other institutions.

项目008 -癌症流行病学研究 项目总结/摘要 随着范德比尔特-英格拉姆癌症中心（VICC）基于人群的研究的显著增长， 原来的癌症流行病学，预防和控制计划，现在分为两个更集中 程序.新成立的癌症流行病学（CE）研究项目，由Wei Zheng，MD，PhD 和Xiao-Ou Shu，MD，PhD，寻求进行高影响力的研究，以提高对病因的理解 和癌症遗传学，并确定癌症风险和预后的生物标志物， 有效的癌症预防策略。CE计划大致分为四个主要的癌症研究 专题领域：1）分子和遗传流行病学; 2）营养、生活方式和 癌症风险的环境因素; 3）癌症存活的预后因素的调查;以及4） 国际研究和健康差距研究。 CE的主要优势之一在于建立和开展大型队列研究， 从223，000名研究参与者中获得的大量接触数据和生物样本。行政长官成员亦 进行大型癌症病例对照研究。这些资源提供了特殊的基于人口的领域 许多重要研究的实验室。CE成员站在识别遗传和 多种癌症的生活方式因素和生物标志物，研究显著提高了对癌症的认识 病因学和遗传学，有助于修改美国癌症协会的生活方式指南， 乳腺癌幸存者，并启动了两项化学预防试验。这项研究直接关系到 维也纳国际中心服务区，涉及这一人口的多个部分，包括历史上 代表性不足的群体。CE还拥有大量的国际研究组合，以测试科学假设 在美国无法充分调查基于研究，并在多个大型 癌症流行病学联盟。CE主办了三个NIH资助的培训项目，并成功地培养了 多名初级调查员的职业发展 有来自五个部门和两所学校的26名项目成员，NCI资助了1100万美元 以及150万美元的其他同行评审癌症相关资金。在421份出版物中，58%是方案内出版物 63%是跨项目的。成员还与其他研究人员合作出版了181份出版物 机构职能体系