Quantifying the Mechanism and Impact of Hip Extensor Muscle Dysfunction During Aerobic Exercise in Hip Osteoarthritis

量化髋部骨关节炎有氧运动期间髋部伸肌功能障碍的机制和影响

• 批准号: 10449466
• 负责人: Michael A Samaan
• 金额: $ 12.8万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10449466
• 关键词: Advisory Committees; Aerobic Exercise; Age; Aging; Area; Biochemical; Biological Markers; Biomechanics; Biometry; Cartilage; Cartilage Matrix; Chronic; Clinical; Data; Degenerative polyarthritis; Development; Disease; Disease Progression; Elderly; Exercise; Exhibits; Extensor; Fibrosis; Functional disorder; Goals; Health; Hip Joint; Hip Osteoarthritis; Hip Pain; Hip region structure; Image; Intervention; Knee Osteoarthritis; Knowledge; Lead; Literature; Magnetic Resonance Imaging; Measures; Mechanical Stress; Mechanics; Mentored Research Scientist Development Award; Muscle; Muscle function; Musculoskeletal; Pain; Patient Self-Report; Patients; Physical therapy; Population; Principal Investigator; Protocols documentation; Recommendation; Research; Research Personnel; Resources; Serum; Stress Tests; Techniques; Therapeutic; Torque; Total Hip Replacement; Training; United States; Work; age related; aging population; base; career; chronic pain patient; exercise intervention; exercise program; gait rehabilitation; improved; innovation; insight; joint loading; mammalian COMP; multidisciplinary; multimodality; muscle physiology; novel; novel imaging technique; preservation; programs; prospective; simulation; skills; symptom treatment

Project Summary/Abstract Hip osteoarthritis (OA) impacts approximately 25% of the population over the age of 45 years. Current conservative treatments include exercise-based programs yet these interventions are ineffective in reducing hip OA-related clinical and functional abnormalities. One limitation of these exercise programs is the lack of evidence used to establish these treatment paradigms, which leads to the ineffectiveness of these programs in treating hip OA. Current experimental protocols used to inform exercise programs for the hip OA population lack precision in measuring hip joint muscular dysfunction. Therefore, there is a need to establish an experimental platform that can precisely measure hip joint muscular dysfunction. The novel experimental platform proposed in this application will be able to precisely assess hip muscle dysfunction and will provide clinicians with the evidence needed to develop effective multi-disciplinary, exercise programs for conservative treatment of symptomatic hip OA. The principal investigator (PI) of this K01 award will develop a novel, multi-modal experimental platform that will precisely measure the effects of hip extensor muscle dysfunction in patients with symptomatic hip OA. The PI will utilize novel imaging techniques and assessment of muscle torque development to assess the pathomechanism of hip extensor dysfunction in patients with symptomatic hip OA. The corresponding effects of hip extensor dysfunction during aerobic exercise (mechanical stress test) will be assessed in patients with symptomatic hip OA. Musculoskeletal simulations and serum-based biomarkers of cartilage health will be used to quantify the changes that occur in hip joint contact forces and systemic cartilage turnover/synthesis, respectively, during the mechanical stress test. These study results will be used to determine the relationship of gluteus maximus muscle fibrosis and hip extensor rate of torque development with changes in hip loading, cartilage health and self-reported hip pain in the symptomatic hip OA population. Upon completion of this K01 project, the applicant will possess the knowledge needed to implement this novel experimental platform on a large scale basis to assess the longitudinal relationship between hip extensor dysfunction with hip OA disease progression in the subsequent R01 application. The PI has developed a strong training plan in aging, muscle-imaging, muscle-physiology and biochemical biomarkers. The PI has established a diverse advisory committee with expertise in aging, physical therapy, biomechanics, muscle-physiology, exercise for OA, biomarkers of OA and biostatistics. This K01- award will provide the PI with the training and resources needed to accomplish the goals of this project and will lead the PI towards a successful career as an independent investigator in aging-related research.

项目概要/摘要 髋骨关节炎 (OA) 影响着 45 岁以上人口的约 25%。当前的 保守治疗包括基于运动的计划，但这些干预措施无法有效减少 髋关节 OA 相关的临床和功能异常。这些锻炼计划的一个局限性是缺乏 用于建立这些治疗范式的证据，导致这些方案在 治疗髋关节骨关节炎。当前用于为髋部 OA 人群制定锻炼计划的实验方案 测量髋关节肌肉功能障碍缺乏精确性。因此，有必要建立一个 可以精确测量髋关节肌肉功能障碍的实验平台。小说实验 本申请中提出的平台将能够精确评估髋部肌肉功能障碍，并提供 临床医生拥有为保守派制定有效的多学科锻炼计划所需的证据 治疗症状性髋关节骨关节炎。 本次K01奖的首席研究员（PI）将开发一个新颖的多模态实验平台 这将精确测量髋部伸肌功能障碍对有症状的髋部 OA 患者的影响。 PI 将利用新颖的成像技术和肌肉扭矩发展评估来评估 有症状的髋关节 OA 患者髋部伸肌功能障碍的病理机制。对应的效果 将评估有氧运动（机械压力测试）期间髋部伸肌功能障碍的患者 有症状的髋关节骨关节炎。将使用肌肉骨骼模拟和基于血清的软骨健康生物标志物 量化髋关节接触力和全身软骨更新/合成发生的变化， 分别在机械应力测试期间。这些研究结果将用于确定关系 臀大肌纤维化和髋部伸肌扭矩发展速率随髋部负荷变化的变化， 有症状的髋部 OA 人群的软骨健康状况和自我报告的髋部疼痛。完成本 K01 后 项目，申请人将拥有在一个平台上实施这个新颖的实验平台所需的知识 大规模基础评估髋关节伸肌功能障碍与髋关节 OA 疾病之间的纵向关系 后续R01申请的进展。 PI 在衰老、肌肉成像、肌肉生理学和 生化生物标志物。 PI 建立了一个多元化的咨询委员会，拥有老龄化、身体健康等方面的专业知识。 治疗、生物力学、肌肉生理学、骨关节炎运动、骨关节炎生物标志物和生物统计学。这个K01- 奖项将为 PI 提供实现该项目目标所需的培训和资源，并将 带领 PI 作为衰老相关研究的独立研究者取得成功的职业生涯。