Emotional Awareness: An integrative neural mechanism linking childhood trauma with psychopathology

情绪意识：将童年创伤与精神病理学联系起来的综合神经机制

• 批准号: 10449625
• 负责人: David G Weissman
• 金额: $ 12.28万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10449625
• 关键词: Adolescence; Adolescent; Affective; Amygdaloid structure; Anger; Anterior; Area; Awareness; Behavioral; Brain; Brain region; Chronic; Clinical; Cognition; Cues; Detection; Development; Early Intervention; Ecological momentary assessment; Emotional; Emotions; Exposure to; Functional Magnetic Resonance Imaging; Grain; Incidence; Individual; Individual Differences; Insula of Reil; Interoception; Interpersonal Violence; Intervention; Knowledge; Label; Life; Link; Measures; Mediating; Mental Health; Methods; Modeling; Neurophysiology - biologic function; Patient Self-Report; Perception; Phase; Physiological; Play; Prefrontal Cortex; Process; Properdin; Psychopathology; Research; Risk; Role; Sample Size; Sampling; Self Perception; System; Testing; Work; Youth; aged; behavior measurement; behavioral health; biological adaptation to stress; emotion regulation; emotional functioning; experience; follow up assessment; improved outcome; longitudinal design; multimodality; neural circuit; neuroimaging; neuromechanism; novel; pediatric trauma; pre-clinical; psychologic; recruit; relating to nervous system; research study; response; rumination; skills; trauma exposure

PROJECT SUMMARY Childhood trauma is common and increases risk for multiple forms of psychopathology emerging in adolescence. Enhanced threat detection, heightened emotional reactivity, altered physiological responses, and difficulties with emotion regulation have all been identified as emotion processes linking childhood trauma with psychopathology. However, existing knowledge on mechanisms linking childhood trauma and psychopathology—including altered perceptions, cognitions, and neural mechanisms—is poorly integrated and has yet to contribute to effective preclinical interventions. The proposed project tests the hypothesis that emotional awareness and the associated neural circuitry is an integrative mechanism linking childhood trauma with transdiagnostic psychopathology risk in adolescence. Emotional awareness is an aspect of self- knowledge, which reflects an individual’s subjective understanding of their emotional state. In the K99 phase study, the role of emotional awareness in the association between childhood trauma and psychopathology will be investigated in a sample of 80 adolescents aged 13-18 years, half with exposure to childhood trauma. Emotional awareness and related emotion processes will be assessed at multiple levels of analysis including self-report, behavioral tasks, and neural function. Multiple forms of psychopathology will be assessed and used to construct a general psychopathology (“p”) factor. Analyses will evaluate the relation between childhood trauma and low emotional awareness and whether low emotional awareness explains the link between childhood trauma and general psychopathology (Aim 1). The K99 study will also identify aspects of neural function during emotion labelling and interoception that correspond with behavioral measures of emotion differentiation and interoceptive accuracy (Aim 2). The R00 phase aims to expand on the K99 findings using a larger sample size that is more appropriate for individual differences analyses and a longitudinal design. This study will recruit 120 adolescents aged 13-18 to investigate how childhood trauma influences emotional awareness across adolescence and will include a behavioral and mental health follow-up assessment 18 months later. Analyses will investigate whether that association is mediated by enhanced threat detection, heightened emotional reactivity, and low interoceptive accuracy (Aim 3). Associations between CT, emotion differentiation, emotion regulation, and psychopathology in adolescents’ daily lives will be investigated using ecological momentary assessments (EMA) (Aim 4). Analyses will also evaluate whether neural mechanisms related to emotional awareness, identified in the K99 study link CT with psychopathology (Aim 5). The proposed research tests an integrative model of the affective mechanisms linking childhood trauma with psychopathology, with the potential to identify novel targets for early interventions. The project ties together the candidate’s diverse research experience and will provide him with the opportunity to build capacity and skills in key areas that will aid in his transition to research independence.

项目摘要 童年创伤是常见的，并增加了多种形式的精神病理学出现的风险， 青春期增强的威胁检测，提高情绪反应，改变生理反应， 情绪调节的困难都被认为是与童年创伤有关的情绪过程， 精神病理学然而，关于儿童创伤和 精神病理学--包括改变的知觉、认知和神经机制--整合不良， 尚未对有效的临床前干预做出贡献。拟议的项目检验的假设是， 情绪意识和相关的神经回路是一种整合机制， 在青春期有跨诊断精神病理学风险。情感意识是自我的一个方面， 知识，它反映了一个人对自己情绪状态的主观理解。在K99阶段 研究表明，情绪意识在儿童创伤和精神病理学之间的联系中所起的作用将 在80名13-18岁的青少年样本中进行调查，其中一半有童年创伤。 情绪意识和相关的情绪过程将在多个分析层次进行评估，包括 自我报告、行为任务和神经功能。多种形式的精神病理学将被评估和使用 以构建一般精神病理学（“p”）因素。分析将评估童年与 创伤和低情绪意识以及低情绪意识是否解释了 儿童创伤和一般精神病理学（目标1）。K99研究还将确定神经系统的各个方面， 与情绪行为测量相对应的情绪标记和内感受功能 差异化和内感受准确性（目标2）。R 00阶段的目标是使用 更大的样本量更适合个体差异分析和纵向设计。这 研究将招募120名13-18岁的青少年，调查童年创伤如何影响情绪 在整个青春期的认识，并将包括行为和心理健康的后续评估18 月后分析将调查这种关联是否是由增强的威胁检测介导的， 情绪反应性增强，内感受准确性低（目标3）。CT与情绪之间的关系 青少年日常生活中的分化，情绪调节和精神病理学将使用 生态瞬时评估（目标4）。分析还将评估神经机制是否 K99研究将CT与精神病理学联系起来（目标5）。的 拟议的研究测试了一个情感机制的综合模型，该模型将儿童创伤与 精神病理学，有可能确定新的早期干预目标。该项目将 候选人的多样化的研究经验，并将为他提供机会，建立能力和技能， 关键领域，这将有助于他过渡到研究独立。