High Resolution Ultrasound in Interventional Radiology

介入放射学中的高分辨率超声

• 批准号: 10448971
• 负责人: Katherine W Ferrara
• 金额: $ 62.46万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-04 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448971
• 关键词: Abdomen; Ablation; Acoustics; Address; Adult; Adverse effects; Algorithms; Anatomy; Animals; Biopsy; Blood flow; Buffers; California; Cancerous; Clinical; Color; Contrast Media; Crystallization; Cyst; Dependence; Development; Diagnosis; Diagnostic Imaging; Dimensions; Disease; Electronics; Elements; Exposure to; Family suidae; Future; Geometry; Hospitals; Image; Image Enhancement; Imaging Device; Individual; Intervention; Intervention Studies; Interventional Imaging; Interventional radiology; Ionizing radiation; Lesion; Liquid substance; Liver; Magnetic Resonance Imaging; Maps; Medical Imaging; Methods; Monitor; Needle biopsy procedure; Needles; Noise; Operative Surgical Procedures; Patients; Performance; Physiology; Procedures; Protocols documentation; Radiation; Radiation Dose Unit; Radiology Specialty; Resolution; Resource-limited setting; Scanning; Signal Transduction; Speed; System; Technology; Testing; Time; Tissues; Transducers; Ultrasonography; Universities; Update; Vision; Visualization; X-Ray Computed Tomography; angiogenesis; base; clinical application; contrast enhanced; contrast enhanced computed tomography; contrast imaging; cost; design; high resolution imaging; image guided; image guided intervention; imaging modality; imaging software; imaging study; imaging system; improved; in vivo; integrated circuit; liver ablation; liver imaging; liver visualization; microwave ablation; minimally invasive; nephrotoxicity; novel; three-dimensional visualization; tool; transmission process; tumor; ultrasound; vector; volunteer

We seek to create a real-time ultrasound imaging tool for guiding interventions, with resolution that exceeds that obtained using CT but without the need for radiation or iodinated contrast agents. Advancements in medical imaging and device technology allow minimally-invasive procedures for the diagnosis and treatment of various disorders. Real-time ultrasound has become an integral aspect of many image-guided interventions. Advantages of US imaging include the low cost, lack of ionizing radiation and real-time visualization of anatomy and physiology. Our approach will be to: 1) create an extended aperture 2D transducer (512 by 16 elements) capable of imaging an extended azimuthal field of 9 cm with in-plane resolution of hundreds of microns (to provide a wide field of view at high resolution), 2) apply the 2D array to image multiple adjacent planes (to facilitate the view of biopsy needles or ablations), 3) achieve a 30 volume per second update rate by using plane wave transmissions to enhance contrast imaging modes and implement novel beam formation algorithms, 4) integrate methods for aberration correction, and 5) apply this technology in B-Mode, color Doppler, volumetric vector flow imaging and contrast imaging. The array will be realized using tiled modules that can be switched in a mode-dependent fashion to accomplish B-Mode imaging, color Doppler and contrast imaging. Over the past 4 years, Stanford and the University of Southern California have designed an adult extended-aperture abdominal-imaging system and demonstrated the improved spatial resolution, field of view and contrast that can be achieved. We exploit these tools here to develop a high-volume rate capability for monitoring liver interventions. Our aims to accomplish this are to: 1) Create and integrate tileable acoustic/electronic modules to implement signal buffering and multiplexing and create a large aperture array with elevational focusing. Utilizing newly designed Integrated Circuits (IC)’s and highly sensitive and wide-bandwidth single crystal transducer material, we will construct individual 2D array modules with co-integrated transducers and electronics. 2) Optimize the protocols for guiding biopsy and ablation in phantom and animal studies. A) Create software for imaging of small lesions and microwave ablation. We will implement singular value decomposition (SVD) based beam formation for aberration correction. B) Evaluate performance in phantoms and ex vivo tissue. C) Assess speed and accuracy of needle placements. D) Conduct contrast imaging and ablative studies in porcine liver in vivo. 3) Conduct diagnostic and interventional imaging studies as a proof of concept. A) Test the protocols to image the liver of adult volunteers and establish the signal to noise ratio in vivo as compared with phantoms. B) Assess 3D visualization of liver vasculature and lesions in patients referred for MR or CT imaging of a liver lesion. C) Compare the 3D visualization of ablated zones to contrast-enhanced CT (CECT) in patients that are referred for liver ablation.

我们寻求创建一种用于指导干预的实时超声成像工具，其分辨率超过 使用 CT 获得，但无需辐射或碘造影剂。医学的进步 成像和设备技术允许微创手术诊断和治疗各种疾病 失调。实时超声已成为许多图像引导干预措施的一个组成部分。优点 美国成像的优点包括低成本、缺乏电离辐射和解剖结构的实时可视化 生理。我们的方法是：1) 创建一个具有扩展孔径的 2D 传感器（512 x 16 元件） 成像 9 厘米的扩展方位角场，面内分辨率为数百微米（以提供宽 高分辨率视场），2）应用2D阵列对多个相邻平面进行成像（以方便查看 活检针或消融），3）通过使用平面波传输实现每秒 30 体积的更新率 为了增强对比度成像模式并实现新颖的波束形成算法，4）集成方法 像差校正，5) 将此技术应用于 B 模式、彩色多普勒、体积矢量流成像和 对比成像。该阵列将使用平铺模块来实现，这些模块可以根据模式进行切换 时尚来完成 B 型成像、彩色多普勒和对比成像。过去 4 年里，斯坦福大学和 南加州大学设计了一种成人大孔径腹部成像系统 展示了可以实现的改进的空间分辨率、视野和对比度。我们利用这些 这里的工具可开发用于监测肝脏干预的高容量速率能力。我们的目标是实现这一目标 目的是： 1) 创建并集成可平铺的声学/电子模块以实现信号缓冲和复用 并创建具有仰角聚焦的大孔径阵列。利用新设计的集成电路（IC） 和高灵敏度、宽带宽的单晶换能器材料，我们将构建单独的二维阵列 具有共同集成的传感器和电子设备的模块。 2）优化指导活检和消融的方案 在幻觉和动物研究中。 A) 创建用于小病变成像和微波消融的软件。我们 将实施基于奇异值分解（SVD）的波束形成以进行像差校正。 B）评估 在体模和离体组织中的表现。 C) 评估针放置的速度和准确性。 D) 行为 猪肝脏体内对比成像和消融研究。 3）进行诊断和介入成像 研究作为概念证明。 A) 测试成年志愿者肝脏成像协议并建立信号 体内与模型相比的噪声比。 B) 评估肝血管系统和病变的 3D 可视化 转诊进行肝脏病变 MR 或 CT 成像的患者。 C) 将消融区域的 3D 可视化与 对转诊进行肝脏消融的患者进行对比增强 CT (CECT)。