High Resolution Ultrasound in Interventional Radiology
介入放射学中的高分辨率超声
基本信息
- 批准号:10448971
- 负责人:
- 金额:$ 62.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-04 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:AbdomenAblationAcousticsAddressAdultAdverse effectsAlgorithmsAnatomyAnimalsBiopsyBlood flowBuffersCaliforniaCancerousClinicalColorContrast MediaCrystallizationCystDependenceDevelopmentDiagnosisDiagnostic ImagingDimensionsDiseaseElectronicsElementsExposure toFamily suidaeFutureGeometryHospitalsImageImage EnhancementImaging DeviceIndividualInterventionIntervention StudiesInterventional ImagingInterventional radiologyIonizing radiationLesionLiquid substanceLiverMagnetic Resonance ImagingMapsMedical ImagingMethodsMonitorNeedle biopsy procedureNeedlesNoiseOperative Surgical ProceduresPatientsPerformancePhysiologyProceduresProtocols documentationRadiationRadiation Dose UnitRadiology SpecialtyResolutionResource-limited settingScanningSignal TransductionSpeedSystemTechnologyTestingTimeTissuesTransducersUltrasonographyUniversitiesUpdateVisionVisualizationX-Ray Computed Tomographyangiogenesisbaseclinical applicationcontrast enhancedcontrast enhanced computed tomographycontrast imagingcostdesignhigh resolution imagingimage guidedimage guided interventionimaging modalityimaging softwareimaging studyimaging systemimprovedin vivointegrated circuitliver ablationliver imagingliver visualizationmicrowave ablationminimally invasivenephrotoxicitynovelthree-dimensional visualizationtooltransmission processtumorultrasoundvectorvolunteer
项目摘要
We seek to create a real-time ultrasound imaging tool for guiding interventions, with resolution that exceeds that
obtained using CT but without the need for radiation or iodinated contrast agents. Advancements in medical
imaging and device technology allow minimally-invasive procedures for the diagnosis and treatment of various
disorders. Real-time ultrasound has become an integral aspect of many image-guided interventions. Advantages
of US imaging include the low cost, lack of ionizing radiation and real-time visualization of anatomy and
physiology. Our approach will be to: 1) create an extended aperture 2D transducer (512 by 16 elements) capable
of imaging an extended azimuthal field of 9 cm with in-plane resolution of hundreds of microns (to provide a wide
field of view at high resolution), 2) apply the 2D array to image multiple adjacent planes (to facilitate the view of
biopsy needles or ablations), 3) achieve a 30 volume per second update rate by using plane wave transmissions
to enhance contrast imaging modes and implement novel beam formation algorithms, 4) integrate methods for
aberration correction, and 5) apply this technology in B-Mode, color Doppler, volumetric vector flow imaging and
contrast imaging. The array will be realized using tiled modules that can be switched in a mode-dependent
fashion to accomplish B-Mode imaging, color Doppler and contrast imaging. Over the past 4 years, Stanford and
the University of Southern California have designed an adult extended-aperture abdominal-imaging system and
demonstrated the improved spatial resolution, field of view and contrast that can be achieved. We exploit these
tools here to develop a high-volume rate capability for monitoring liver interventions. Our aims to accomplish this
are to: 1) Create and integrate tileable acoustic/electronic modules to implement signal buffering and multiplexing
and create a large aperture array with elevational focusing. Utilizing newly designed Integrated Circuits (IC)’s
and highly sensitive and wide-bandwidth single crystal transducer material, we will construct individual 2D array
modules with co-integrated transducers and electronics. 2) Optimize the protocols for guiding biopsy and ablation
in phantom and animal studies. A) Create software for imaging of small lesions and microwave ablation. We
will implement singular value decomposition (SVD) based beam formation for aberration correction. B) Evaluate
performance in phantoms and ex vivo tissue. C) Assess speed and accuracy of needle placements. D) Conduct
contrast imaging and ablative studies in porcine liver in vivo. 3) Conduct diagnostic and interventional imaging
studies as a proof of concept. A) Test the protocols to image the liver of adult volunteers and establish the signal
to noise ratio in vivo as compared with phantoms. B) Assess 3D visualization of liver vasculature and lesions in
patients referred for MR or CT imaging of a liver lesion. C) Compare the 3D visualization of ablated zones to
contrast-enhanced CT (CECT) in patients that are referred for liver ablation.
我们试图创造一种实时超声成像工具来指导干预,其分辨率超过了它
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Katherine W Ferrara其他文献
Katherine W Ferrara的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Katherine W Ferrara', 18)}}的其他基金
High Resolution Ultrasound in Interventional Radiology
介入放射学中的高分辨率超声
- 批准号:
10584507 - 财政年份:2022
- 资助金额:
$ 62.46万 - 项目类别:
Quantitative volumetric ultrasonic and photoacoustic tomography
定量体积超声和光声断层扫描
- 批准号:
10374704 - 财政年份:2021
- 资助金额:
$ 62.46万 - 项目类别:
Quantitative volumetric ultrasonic and photoacoustic tomography
定量体积超声和光声断层扫描
- 批准号:
10541211 - 财政年份:2021
- 资助金额:
$ 62.46万 - 项目类别:
相似海外基金
Targeted ablation of cerebral atherosclerosis using supramolecular self-assembly
利用超分子自组装靶向消融脑动脉粥样硬化
- 批准号:
24K21101 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
心房細動に対するPulsed Field Ablationの組織創傷治癒過程を明らかにする網羅的研究
阐明房颤脉冲场消融组织伤口愈合过程的综合研究
- 批准号:
24K11201 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
遅延造影心臓MRIによる心房細動Ablation冷却効果の比較:28 vs. 31 mm Cryoballoon
使用延迟对比增强心脏 MRI 比较房颤消融冷却效果:28 毫米与 31 毫米 Cryoballoon
- 批准号:
24K11281 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
InSPACE-VT_Development and Validation of Virtual Pace Mapping to Guide Catheter Ablation of Ventricular Tachycardia
InSPACE-VT_虚拟起搏测绘的开发和验证以指导室性心动过速导管消融
- 批准号:
EP/Z001145/1 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Fellowship
CAREER: Heat Penetration Depth and Direction Control with Closed-Loop Device for Precision Ablation
职业:利用闭环装置控制热穿透深度和方向,实现精确烧蚀
- 批准号:
2338890 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334777 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334775 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Continuing Grant
Collaborative Research: RUI: Frontal Ablation Processes on Lake-terminating Glaciers and their Role in Glacier Change
合作研究:RUI:湖终止冰川的锋面消融过程及其在冰川变化中的作用
- 批准号:
2334776 - 财政年份:2024
- 资助金额:
$ 62.46万 - 项目类别:
Continuing Grant
Cryo laser-ablation system (157+193nm) with 'triple-quad' plasma mass spectrometer, Cryo-LA-ICPMS/MS
带有“三重四极杆”等离子体质谱仪、Cryo-LA-ICPMS/MS 的冷冻激光烧蚀系统 (157 193nm)
- 批准号:
515081333 - 财政年份:2023
- 资助金额:
$ 62.46万 - 项目类别:
Major Research Instrumentation
MRI: Acquisition of a Laser Ablation - Inductively Coupled Plasma - Triple Quadrupole - Mass Spectrometer (LA-ICP-QQQ-MS) System For Research and Education
MRI:获取用于研究和教育的激光烧蚀 - 电感耦合等离子体 - 三重四极杆 - 质谱仪 (LA-ICP-MS/MS) 系统
- 批准号:
2320040 - 财政年份:2023
- 资助金额:
$ 62.46万 - 项目类别:
Standard Grant














{{item.name}}会员




