Quantitative volumetric ultrasonic and photoacoustic tomography

定量体积超声和光声断层扫描

• 批准号: 10374704
• 负责人: Katherine W Ferrara
• 金额: $ 61.98万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374704
• 关键词: 3-Dimensional; Address; Algorithms; Benign; Biopsy; Blood; Blood flow; Breast; Breast Cancer Detection; Breast Cancer Model; Breast Magnetic Resonance Imaging; Clinical; Complement; Contrast Media; Data; Data Science; Data Set; Detection; Development; Diagnostic Factor; Diagnostic Imaging; Engineering; Fatty acid glycerol esters; Floor; Frequencies; Functional Imaging; Goals; Hemoglobin; Human body; Hypoxia; Image; Individual; Italy; Lasers; Lesion; Literature; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Neoplasms; Methods; Modeling; Morphology; Mus; Noise; Optics; Partner in relationship; Patient imaging; Performance; Population; Predictive Value; Prognostic Factor; Radiation; Real-Time Systems; Reporting; Resolution; Risk; Rodent Model; Scanning; Sensitivity and Specificity; Signal Transduction; Site; Specificity; Speed; System; Techniques; Technology; Testing; Time; Tissue imaging; Transducers; Ultrasonic Tomography; Ultrasonography; Update; Visualization; Weight; Woman; absorption; angiogenesis; base; breast imaging; breast lesion; breast scanner; contrast enhanced; contrast imaging; convolutional neural network; cost; design; human study; imaging modality; imaging study; imaging system; improved; interest; intravenous injection; malignant breast neoplasm; mammary; mouse model; optoacoustic tomography; photoacoustic imaging; premalignant; real-time images; screening; standard of care; technology development; tomography; transmission process; tumor; ultrasound; vector; volunteer

Abstract Our central goal is to create a volumetric real-time system combining ultrasound (US) and photoacoustic (PA) tomography (USPAT) for high resolution structural and functional imaging. The recent development of high channel count ultrafast US systems creates the opportunity to capture volumes at a high frame rate. Tomography, defined as a technique for displaying a representation of a cross section through a human body, facilitates high resolution (lamba/2) imaging by effectively rotating the US point spread function to reduce the effect of diffraction. We have developed an ultrafast US capability mated to a tomographic ring of transducers and scanned in depth by motorized acquisition. Leveraging the ultrafast capability provides the opportunity for acquisition of volumetric, functional breast images within 1 minute. The acquisition is controlled by 1024 coherent channels of Verasonics imaging systems (to be increased to 2048) and includes embedded GPUs for real-time imaging and analysis. When operated at 5 MHz, the resulting spatial resolution is nearly isotropic in plane with resolution of ~ half a wavelength (in this case ~150 microns). Compared to US images acquired with conventional imaging, the image quality is far improved. Ultrasound methods are attractive for integration into breast management due to their utility in guiding biopsy and the very high sensitivity (97.3%) that can be achieve by combining ultrasound with conventional screening. Both transmission and reflection tomography modes will be evaluated in order to facilitate both high resolution reflective modes and highly quantitative transmission imaging. PA imaging (PAI) is particularly well suited to complement US and improve diagnostic imaging of the breast. Our immediate goal is to reduce the number of biopsies required in women undergoing breast screening. Photoacoustic tomography (PAT) enhances the signal to noise ratio and visualization of morphology over conventional PAI. Healthy breast tissue has low optical absorption and US scattering, allowing for highly efficient PAT. Since abnormally increased vasculature and hemoglobin at tumor sites produces strong intrinsic photoacoustic contrast, PAT is ideally suited for visualizing angiogenesis. Further, PAT can assess the relative oxygenation of a region. With our combined strategy, we will evaluate characterization algorithms based on each feature – blood flow, oxygenation and structural changes, assessing the sensitivity of individual and combined imaging features. With a first study of this technique in a mouse model of premalignant to malignant transformation and a human study of lesion characterization, we will determine whether USPAT can add to the sensitivity and specificity of lesion characterization by MRI. Our resulting specific aims are to: 1) implement and integrate blood mapping, US tomography, and PAT for breast imaging, 2) assess the sensitivity and specificity of the resulting system in a rodent model of breast cancer, and 3) apply these new capabilities to image patients with MRI detected abnormalities recommended for biopsy.

抽象的 我们的中心目标是创建一个结合超声波（US）和光声（PA）的体积实时系统 用于高分辨率结构和功能成像的断层扫描 (USPAT)。近期发展高 通道数超快美国系统创造了以高帧速率捕获体积的机会。 断层扫描，定义为一种显示人体横截面表示的技术， 通过有效旋转 US 点扩散函数来减少高分辨率 (lamba/2) 成像 衍射效应。我们开发了一种与换能器断层扫描环相匹配的超快 US 功能 并通过机动采集进行深度扫描。利用超快能力提供了机会 1 分钟内获取体积、功能性乳房图像。采集由1024相干控制 Verasonics 成像系统通道（将增加至 2048 个），并包括用于实时处理的嵌入式 GPU 成像和分析。当工作频率为 5 MHz 时，所产生的空间分辨率在平面上几乎各向同性 分辨率约为半波长（在本例中约为 150 微米）。与使用以下方法获取的美国图像相比 与传统成像相比，图像质量大大提高。超声方法对于集成到 乳房管理因其在引导活检中的实用性以及非常高的 可达到的灵敏度（97.3%） 通过将超声波与传统筛查相结合。 透射和反射断层扫描模式都将 进行评估，以促进高分辨率反射模式和高度定量传输 成像。 PA 成像 (PAI) 特别适合补充 US 并改善超声诊断成像 胸部。我们的近期目标是减少接受乳腺筛查的女性所需的活检数量。 光声断层扫描 (PAT) 增强了信噪比和形态可视化 常规 PAI。健康的乳腺组织具有较低的光吸收和美国散射，可实现高效 拍。由于肿瘤部位异常增加的脉管系统和血红蛋白会产生强烈的内在 光声对比，PAT 非常适合可视化血管生成。此外，PAT 可以评估相对 一个区域的氧化。通过我们的组合策略，我们将基于以下内容评估表征算法 每个特征——血流、氧合和结构变化，评估个体和个体的敏感性 结合成像特征。首次在小鼠癌前至恶性模型中研究了该技术 转化和病变特征的人体研究，我们将确定 USPAT 是否可以添加到 MRI 病变表征的敏感性和特异性。我们最终的具体目标是： 1) 实施和 整合血液测绘、超声断层扫描和 PAT 进行乳腺成像，2) 评估敏感性和特异性 所得系统在乳腺癌啮齿动物模型中的应用，以及 3) 将这些新功能应用于患者成像 MRI 检测到异常，建议进行活检。