Quantitative volumetric ultrasonic and photoacoustic tomography

定量体积超声和光声断层扫描

• 批准号: 10374704
• 负责人: Katherine W Ferrara
• 金额: $ 61.98万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374704
• 关键词: 3-Dimensional; Address; Algorithms; Benign; Biopsy; Blood; Blood flow; Breast; Breast Cancer Detection; Breast Cancer Model; Breast Magnetic Resonance Imaging; Clinical; Complement; Contrast Media; Data; Data Science; Data Set; Detection; Development; Diagnostic Factor; Diagnostic Imaging; Engineering; Fatty acid glycerol esters; Floor; Frequencies; Functional Imaging; Goals; Hemoglobin; Human body; Hypoxia; Image; Individual; Italy; Lasers; Lesion; Literature; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Mammary Gland Parenchyma; Mammary Neoplasms; Methods; Modeling; Morphology; Mus; Noise; Optics; Partner in relationship; Patient imaging; Performance; Population; Predictive Value; Prognostic Factor; Radiation; Real-Time Systems; Reporting; Resolution; Risk; Rodent Model; Scanning; Sensitivity and Specificity; Signal Transduction; Site; Specificity; Speed; System; Techniques; Technology; Testing; Time; Tissue imaging; Transducers; Ultrasonic Tomography; Ultrasonography; Update; Visualization; Weight; Woman; absorption; angiogenesis; base; breast imaging; breast lesion; breast scanner; contrast enhanced; contrast imaging; convolutional neural network; cost; design; human study; imaging modality; imaging study; imaging system; improved; interest; intravenous injection; malignant breast neoplasm; mammary; mouse model; optoacoustic tomography; photoacoustic imaging; premalignant; real-time images; screening; standard of care; technology development; tomography; transmission process; tumor; ultrasound; vector; volunteer

Abstract Our central goal is to create a volumetric real-time system combining ultrasound (US) and photoacoustic (PA) tomography (USPAT) for high resolution structural and functional imaging. The recent development of high channel count ultrafast US systems creates the opportunity to capture volumes at a high frame rate. Tomography, defined as a technique for displaying a representation of a cross section through a human body, facilitates high resolution (lamba/2) imaging by effectively rotating the US point spread function to reduce the effect of diffraction. We have developed an ultrafast US capability mated to a tomographic ring of transducers and scanned in depth by motorized acquisition. Leveraging the ultrafast capability provides the opportunity for acquisition of volumetric, functional breast images within 1 minute. The acquisition is controlled by 1024 coherent channels of Verasonics imaging systems (to be increased to 2048) and includes embedded GPUs for real-time imaging and analysis. When operated at 5 MHz, the resulting spatial resolution is nearly isotropic in plane with resolution of ~ half a wavelength (in this case ~150 microns). Compared to US images acquired with conventional imaging, the image quality is far improved. Ultrasound methods are attractive for integration into breast management due to their utility in guiding biopsy and the very high sensitivity (97.3%) that can be achieve by combining ultrasound with conventional screening. Both transmission and reflection tomography modes will be evaluated in order to facilitate both high resolution reflective modes and highly quantitative transmission imaging. PA imaging (PAI) is particularly well suited to complement US and improve diagnostic imaging of the breast. Our immediate goal is to reduce the number of biopsies required in women undergoing breast screening. Photoacoustic tomography (PAT) enhances the signal to noise ratio and visualization of morphology over conventional PAI. Healthy breast tissue has low optical absorption and US scattering, allowing for highly efficient PAT. Since abnormally increased vasculature and hemoglobin at tumor sites produces strong intrinsic photoacoustic contrast, PAT is ideally suited for visualizing angiogenesis. Further, PAT can assess the relative oxygenation of a region. With our combined strategy, we will evaluate characterization algorithms based on each feature – blood flow, oxygenation and structural changes, assessing the sensitivity of individual and combined imaging features. With a first study of this technique in a mouse model of premalignant to malignant transformation and a human study of lesion characterization, we will determine whether USPAT can add to the sensitivity and specificity of lesion characterization by MRI. Our resulting specific aims are to: 1) implement and integrate blood mapping, US tomography, and PAT for breast imaging, 2) assess the sensitivity and specificity of the resulting system in a rodent model of breast cancer, and 3) apply these new capabilities to image patients with MRI detected abnormalities recommended for biopsy.

摘要 我们的中心目标是创建一个结合超声（US）和光声（PA）的体积实时系统 断层扫描（USPAT）用于高分辨率结构和功能成像。最近的发展高 通道计数超快US系统创造了以高帧速率捕获体积的机会。 断层摄影，定义为一种显示人体横截面的技术， 通过有效地旋转US点扩散函数以减少 衍射效应。我们已经开发出一种超快的美国能力配对的断层环的换能器 并通过电动采集进行深度扫描。利用超快能力， 在1分钟内采集体积、功能性乳腺图像。采集由1024相干控制 Verasonics成像系统的2048个通道（将增加到2048个），并包括嵌入式GPU，用于实时 成像和分析。当在5 MHz下操作时，所得到的空间分辨率在平面内几乎是各向同性的， 分辨率约为半个波长（在这种情况下约为150微米）。与使用以下方法获得的US图像相比， 与常规成像相比，图像质量得到了很大的改善。超声方法对于集成到 乳腺管理，因为它们在引导活检中的实用性和非常高的 可达到灵敏度（97.3%） 通过结合超声波和常规筛查。 透射和反射层析成像模式都将 以便促进高分辨率反射模式和高定量透射 显像PA成像（派）特别适合于补充US并改善动脉瘤的诊断成像。 乳房我们的近期目标是减少接受乳腺筛查的妇女所需的活检次数。 光声层析成像（PAT）提高了信噪比和形态的可视化， 常规派。健康的乳房组织具有低的光学吸收和US散射，允许高效的 专利由于肿瘤部位异常增加的血管和血红蛋白产生强烈的内源性 光声对比度，PAT非常适合于可视化血管生成。此外，PAT可以评估相对 一个区域的氧化。通过我们的组合策略，我们将评估基于以下方面的表征算法： 每个特征-血流、氧合和结构变化，评估个体和 结合影像学特征。这项技术首次在小鼠癌前病变至恶性肿瘤模型中进行了研究， 转换和对病变特征的人体研究，我们将确定USPAT是否可以添加到 MRI对病变定性的敏感性和特异性。我们的具体目标是：1）执行和 结合血液标测、超声断层扫描和PAT进行乳腺成像，2）评估灵敏度和特异性 在啮齿动物乳腺癌模型中使用所产生的系统，以及3）将这些新功能应用于患者成像 MRI检测到的异常建议进行活检。