Human Subjects Core

总结/摘要 人类受试者核心B，物理上位于纽约血液中心，将具有集中功能 优化高质量生物样本和临床数据的采集，以支持拟议的研究， 本PPG应用程序中描述的四个项目，以及2）提供基于临床的见解和分析， 实验室的研究人员对他们的研究项目。核心将是与 机构共同调查员，以最大限度地提高工作效率。核心小组的目标包括： 以及通过使用适当的收集、运输、分发、储存和跟踪高质量的研究样本 一个集中的基于云的数据库，每周与临床和实验室研究者举行会议（目标1）; 建立并积极维护高质量人类受试者临床信息的集中数据库， 确保及时准确地将临床变量与实验室分析进行关联和注释（目标2）， 提供临床专业知识和洞察力，在良性血液学和输血医学，以实验室为基础的 研究人员就其研究项目和实验室数据的解释（目标3）。提供这种关键的 临床材料和核心的临床专业知识将促进和增强临床适用性 从这个计划项目中得出的结论。

Summary / Abstract The Human Subjects Core B, physically located at the New York Blood Center, will have a centralized function of 1) optimizing collection of high quality biologic specimens and clinical data to support the proposed studies in the four projects described in this PPG application , and 2) providing clinically-based insights and analysis to the laboratory-based investigators on their research projects. The Core will be the primary contact with the institutional co-investigators to maximize the work efficiency. The aims of the Core include to ensure the timely and proper collection, transport, distribution, storage, and tracking of high-quality research samples through use of an centralized cloud-based database and weekly meetings with the clinical and lab investigators (Aim1); to establish and actively maintain the centralized database of high-quality human subject clinical information to ensure timely and accurate correlation and annotation of clinical variables to laboratory analyses (Aim 2) and to provide clinical expertise and insight in both benign hematology and transfusion medicine to the laboratory-based investigators on their research projects and laboratory data interpretation (Aim 3). Provision of such critical clinical material together with the clinical expertise of the Core will facilitate and enhance the clinical applicability of the findings emerging from this Program Project.