Human Subjects Core

摘要/摘要 位于纽约血液中心的人类受试者核心B将具有集中功能 1)优化高质量生物标本和临床数据的收集，以支持拟议的研究 此PPG应用程序中描述的四个项目，以及2)提供基于临床的洞察和分析 以实验室为基础的调查人员对他们的研究项目。核心将是与 机构协查，最大限度地提高工作效率。核心的目标包括确保及时 以及通过使用适当的收集、运输、分发、存储和跟踪高质量的研究样本 建立一个基于云的中央数据库，并每周与临床和实验室调查人员举行会议(Aim1)； 建立和积极维护高质量的人体受试者临床信息集中数据库，以 确保及时准确地将临床变量与实验室分析进行关联和注释(目标2) 为实验室提供良性血液学和输血医学方面的临床专业知识和见解 调查人员对其研究项目和实验室数据的解释(目标3)。提供这种关键的 临床材料与Core的临床专业知识将促进和提高临床适用性 从该计划项目中得出的结果。

Summary / Abstract The Human Subjects Core B, physically located at the New York Blood Center, will have a centralized function of 1) optimizing collection of high quality biologic specimens and clinical data to support the proposed studies in the four projects described in this PPG application , and 2) providing clinically-based insights and analysis to the laboratory-based investigators on their research projects. The Core will be the primary contact with the institutional co-investigators to maximize the work efficiency. The aims of the Core include to ensure the timely and proper collection, transport, distribution, storage, and tracking of high-quality research samples through use of an centralized cloud-based database and weekly meetings with the clinical and lab investigators (Aim1); to establish and actively maintain the centralized database of high-quality human subject clinical information to ensure timely and accurate correlation and annotation of clinical variables to laboratory analyses (Aim 2) and to provide clinical expertise and insight in both benign hematology and transfusion medicine to the laboratory-based investigators on their research projects and laboratory data interpretation (Aim 3). Provision of such critical clinical material together with the clinical expertise of the Core will facilitate and enhance the clinical applicability of the findings emerging from this Program Project.