Human Subjects Core

人类受试者核心

• 批准号: 10023589
• 负责人: Patricia Ann Shi
• 金额: $ 48.17万
• 依托单位: NEW YORK BLOOD CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10023589
• 关键词: Acute; Benign; Biological; Blood; Characteristics; Clinical; Clinical Data; Code; Collection; Complex; Computer software; Consent; Coordination and Collaboration; Data; Data Analyses; Databases; Drops; Eligibility Determination; Enrollment; Ensure; Floor; Freezing; Future; Hematologist; Hematology; Hemoglobinopathies; Hemolysis; Human Resources; Infrastructure; Laboratories; Logistics; New York; Patient Care; Patient Recruitments; Patient Schedules; Patients; Persons; Physicians; Positioning Attribute; Quality Control; Research; Research Activity; Research Personnel; Research Project Grants; Sampling; Sickle Cell Anemia; Specialist; Specimen; Study Subject; Time; Transfusion; Update; Videoconferences; Work; base; biobank; central database; clinical application; clinical development; clinical material; clinical research site; clinically relevant; cloud based; experience; human subject; insight; interest; meetings; mouse model; programs; sample collection; transfusion medicine

Summary / Abstract The Human Subjects Core B, physically located at the New York Blood Center, will have a centralized function of 1) optimizing collection of high quality biologic specimens and clinical data to support the proposed studies in the four projects described in this PPG application , and 2) providing clinically-based insights and analysis to the laboratory-based investigators on their research projects. The Core will be the primary contact with the institutional co-investigators to maximize the work efficiency. The aims of the Core include to ensure the timely and proper collection, transport, distribution, storage, and tracking of high-quality research samples through use of an centralized cloud-based database and weekly meetings with the clinical and lab investigators (Aim1); to establish and actively maintain the centralized database of high-quality human subject clinical information to ensure timely and accurate correlation and annotation of clinical variables to laboratory analyses (Aim 2) and to provide clinical expertise and insight in both benign hematology and transfusion medicine to the laboratory-based investigators on their research projects and laboratory data interpretation (Aim 3). Provision of such critical clinical material together with the clinical expertise of the Core will facilitate and enhance the clinical applicability of the findings emerging from this Program Project.

摘要/摘要 人类受试者核心 B 物理位置位于纽约血液中心，将具有集中功能 1）优化高质量生物标本和临床数据的收集，以支持拟议的研究 本 PPG 申请中描述的四个项目，以及 2) 为患者提供基于临床的见解和分析 实验室研究人员进行他们的研究项目。核心将是与 机构共同研究者，最大限度地提高工作效率。核心目标包括确保及时 通过使用正确收集、运输、分发、储存和跟踪高质量研究样本 基于云的集中数据库以及与临床和实验室研究人员的每周会议（目标1）；到 建立并积极维护高质量人类受试者临床信息的集中数据库 确保临床变量与实验室分析的及时、准确的关联和注释（目标 2）并 为实验室提供良性血液学和输血医学方面的临床专业知识和见解 研究人员对其研究项目和实验室数据解释（目标 3）。提供此类关键的 临床材料与核心的临床专业知识一起将促进和增强临床适用性 本计划项目的调查结果。