Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions

症状科学、代谢组学和多种慢性病研究中心

• 批准号: 10456828
• 负责人: Linda A. McCauley
• 金额: $ 49.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-14 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456828
• 关键词: Address; Adult; Age; Anxiety; Area; Automobile Driving; Award; Biological; Black Populations; Chronic; Chronic Disease; Chronic stress; Collaborations; Complex; Data; Data Analytics; Data Science; Data Science Core; Deep South; Development; Diet; Direct Costs; Discipline of Nursing; Discrimination; Educational workshop; Faculty; Family; Fatigue; Future; Generations; Genomics; Goals; Health; Health Disparities Research; Human Resources; Hypertension; Individual; Infrastructure; Interdisciplinary Study; Intervention; Intervention Studies; Knowledge; Light; Link; Mental Depression; Mentors; Metabolic Pathway; Modeling; Morbidity - disease rate; Nurses; Nursing Faculty; Outcome; Pathway interactions; Patients; Pharmaceutical Preparations; Pilot Projects; Population; Public Health; Publications; Quality of life; Research; Research Personnel; Resources; School Nursing; Schools; Science; Scientist; Self Management; Severities; Stress; Symptoms; Techniques; Technology; Testing; Time; Translational Research; Translations; United States; Work; base; black men; black women; comorbidity; disease disparity; dysbiosis; experience; gut microbiome; health disparity; health related quality of life; improved; innovation; member; metabolic profile; metabolomics; microbiome; microbiome research; multiple chronic conditions; negative affect; next generation; nursing intervention; peer; pilot test; reduce symptoms; research study; sex; success; symposium; symptom cluster; symptom science; synergism; theories

Over 25% of the adult population in the United States suffers from multiple chronic conditions (MCC), with numbers rising, especially among Black men and women who experience the highest MCC morbidity. Those with MCC often experience symptoms or symptom clusters that undermine their quality of life and ability to self-manage. Importantly, symptom severity in those with even the same MCC varies, suggesting that the mechanisms driving symptoms in MCC are not fixed but vary in ways that may make them amenable to targeted interventions – the very essence of nursing science. The over-arching goal of the “Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions” is to strengthen the capacities of a diverse faculty of nurse scientists to conduct innovative translational research using cutting-edge metabolomics and microbiomic technologies to reduce symptoms in individuals with MCC. The Center’s research aim is to apply next-generation metabolomics technology and data analytic strategies to stimulate discovery of the metabolites and metabolic pathways that are present in individuals with MCC, focusing on the metabolites and metabolic pathways that synergize across conditions and associate with severe symptoms of fatigue, depression, or anxiety and their cluster, but are less represented in individuals with MCC who have minimal or no symptoms. Metabolites and pathways associated with symptoms will be evaluated in light of covariates such as sex as a biological variable, age, stress and discrimination, diet and medications. An exploratory aim will investigate the composition of the gut microbiome as a potential covariate to these symptoms. This aim takes advantage of our School’s strength in microbiome research and evidence linking the microbiome to these symptoms. Pilots 1-3 will examine the circulating metabolites and metabolic profiles that associate with the severity of the symptoms of fatigue, depression, and anxiety in individuals with MCC and in light of covariates, and examine the associations at each time point, while pilot 4 will apply data analytic techniques to model the complex pathways associated with symptom severity, synergy, cluster, and health quality outcomes in MCC. Pilot 5 will test the Pilot 4 model for proof of concept that the metabolites and covariates identified in Pilots 1-3 do associate with symptom severity and are valid targets for intervention. Metabolites associated with symptoms in MCC, including those that synergize, that contribute to clustering, or are microbiome-associated, have yet to be described. Of the 26 Center Personnel, 18 are Center Faculty and Members. Our research base in MCC, self-management, metabolomics, and the microbiome is strong with annual direct costs of $4.7 million. The Center for Data Science is supported with ½ million dollars annually, and will provide infrastructure to the Data Science Core. We will leverage resources of the Emory Metabolomics and Integrated Genomic Cores. Equipping junior faculty to consider complex theories and employ cutting-edge technology, while focused on translation, prepares future nurse scientists to address issues that matter to patients and families.

美国超过 25% 的成年人患有多种慢性病 (MCC)，其中 数字不断上升，尤其是 MCC 发病率最高的黑人男性和女性。那些 MCC 患者经常会出现一些症状或症状群，这些症状或症状群会损害他们的生活质量和能力 自我管理。重要的是，即使患有相同的 MCC，症状的严重程度也会有所不同，这表明 MCC 症状的驱动机制并不固定，而是以多种方式变化，可能导致这些症状 有针对性的干预——护理科学的本质。 “中心”的总体目标 症状科学、代谢组学和多种慢性病的研究”旨在加强患者的能力 由护士科学家组成的多元化教师利用尖端代谢组学进行创新转化研究 微生物组技术可减轻 MCC 患者的症状。该中心的研究目标是 应用下一代代谢组学技术和数据分析策略来刺激发现 MCC 个体中存在的代谢物和代谢途径，重点关注代谢物和 代谢途径在不同条件下协同作用并与严重的疲劳症状相关， 抑郁症、焦虑症及其集群，但在患有 MCC 的个体中较少见，他们的症状很少 或没有症状。将根据协变量评估与症状相关的代谢物和途径 例如性别作为生物变量、年龄、压力和歧视、饮食和药物。探索性目标 将研究肠道微生物组的组成作为这些症状的潜在协变量。这个目标 利用我们学院在微生物组研究方面的优势以及将微生物组与这些相关的证据 症状。试点 1-3 将检查与 MCC 患者疲劳、抑郁和焦虑症状的严重程度以及协变量， 并检查每个时间点的关联，而试点 4 将应用数据分析技术来建模 与 MCC 症状严重程度、协同作用、集群和健康质量结果相关的复杂途径。 试点 5 将测试试点 4 模型，以验证试点 1-3 中确定的代谢物和协变量的概念 确实与症状严重程度相关，并且是干预的有效目标。相关代谢物 MCC 的症状，包括那些协同作用、有助于聚集或与微生物组相关的症状， 尚未描述。在 26 名中心人员中，18 名是中心教职人员和会员。我们的研究基地 在 MCC、自我管理、代谢组学和微生物组方面表现强劲，每年直接成本为 4.7 美元 百万。数据科学中心每年获得 500 万美元的支持，并将提供基础设施 到数据科学核心。我们将利用埃默里代谢组学和综合基因组学的资源 核心。帮助初级教师思考复杂的理论并采用尖端技术，同时 专注于翻译，帮助未来的护士科学家解决对患者和家庭重要的问题。

项目成果

Body Image, Depression Symptoms, and Health-Related Quality of Life in Black Women With Systemic Lupus Erythematosus.

• DOI: 10.1016/j.nwh.2022.07.008
• 发表时间: 2022-08
• 期刊: Nursing for women's health
• 作者: Madeline Jones;L. Kimble

Proceedings of the Summer Institute on Symptoms and Omics.

症状和组学夏季研究所论文集。

• DOI: 10.1177/10998004211050056
• 发表时间: 2022
• 期刊: Biological research for nursing
• 影响因子: 2.5
• 作者: Yang,Irene;Holstad,Marcia
• 通讯作者: Holstad,Marcia