Center for Children's Health, the Environment, the Microbiome, and Metabolomics (C-CHEM2)
儿童健康、环境、微生物组和代谢组学中心 (C-CHEM2)
基本信息
- 批准号:9308957
- 负责人:
- 金额:$ 80.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-09-30 至 2019-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAfrican AmericanBehavioralBiological MarkersBirthBrainChildChild health careClimateCognitiveCohort StudiesCollaborationsCommunitiesCommunity OutreachComplexDataDevelopmentDietDiseaseEndocrine DisruptorsEnvironmentEnvironmental ExposureEnvironmental HealthEvaluationExposure toFamilyFetusFundingFuture GenerationsGeneticGoalsHealthHome environmentHousingImmuneImmune systemInfantInfant HealthInflammatory ResponseInterdisciplinary StudyInterventionKnowledgeLeadLifeLinkLongitudinal cohortMaternal and Child HealthMeasurementMeasuresMetabolicMetabolismMinorityMothersNational Institute of Environmental Health SciencesNeurocognitiveOutcomePilot ProjectsPopulationPregnant WomenPrevalencePreventive MedicineProcessResearchResearch ActivityResearch InfrastructureResearch PersonnelResolutionResourcesRiskSamplingScientistSoutheastern United StatesStressTestingToxic Environmental SubstancesTrainingTranslatingTranslationsUnited StatesUnited States National Institutes of HealthUniversitiesWomanWorkbasecohortdesignfeedingfetalhealth disparityinflammatory markerinterdisciplinary collaborationintergenerationalmetabolomemetabolomicsmetropolitanmicrobiomeneurodevelopmentoffspringoutreachpostnatalpregnantprenatalprenatal exposureprenatal stressprogramspublic health relevanceracial and ethnicresearch studysocial
项目摘要
DESCRIPTION (provided by applicant): The Emory University's "Center for Children's Health, the Environment, Microbiome, and Metabolomics" Center (C- CHEM2) seeks to conduct research on how environmental exposures influence the microbiome of infants and children and the subsequent influence of changes in the microbiome on neurodevelopment. The establishment of a Center focused on the microbiome is significant given that the microbiome is established during the first years of life when development is highly sensitive to the effects of environmental exposures. The investigators' interdisciplinary Center will conduct studies on exposures in an urban environment, the microbiome of pregnant women and their infants, and associated neurocognitive health outcomes. The work of the Center is based on a longitudinal cohort of 800 pregnant African American women who are currently being followed through delivery and designed to examine maternal prenatal stress and its association with the infant microbiome. C-CHEM2 will incorporate a robust assessment of the exposures of the pregnant mother and infant, leveraging substantial resources available from Emory's NIEHS-funded HERCULES Center. The investigators hypothesize that environmental exposure, the microbiome, HPA axis, and immune system together influence neurocognitive and socioemotional development. Type of delivery, genetics, type of feeding, postnatal stress, and maternal-infant interaction are posited as moderators of this intergenerational risk process. Project 1 will focus on the measurement of environmental exposures of the pregnant women and their infants and specifically the association of internal exposures to endocrine-disrupting chemicals in the home environment and their associations with birth outcome. Project 2 will collect infant microbiome, inflammatory marker, and developmental data to examine the association between the prenatal exposures, the infant gut-brain axis, and cognitive/behavioral functioning in the first 18 months of life. Project 3 will use high-resolution metabolomics of the pre- and postnatal samples to test for complex interactions (e.g., exposure x metabolome, microbiome x metabolome, metabolome x HPA axis, immune, neurocognitive and socioemotional measures) that contribute to neurocognitive and socioemotional outcomes. The Community Outreach and Translation Core of C-CHEM2 builds on substantial community engagement already in place in their NIEHS-funded HERCULES Center and provides for bi-directional exchange between African American families in Atlanta and scientists. The investigators' ultimate goal is to assess the influence of the environmental exposures of pregnant women on their microbiome and the subsequent impact of the mother's microbiome on neurodevelopment of the fetus and infant. Achieving this goal would afford a more complete understanding of these effects and consequent ability to translate research strategies to reduce environmental exposures and reduce the prevalence of environmentally-related diseases mitigated by the microbiome.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Linda A. McCauley其他文献
HANDBOOK OF TOXICOLOGY OF CHEMICAL WARFARE AGENTS
- DOI:
10.1016/b978-0-12-374484-5.x0001-6 - 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
Linda A. McCauley - 通讯作者:
Linda A. McCauley
U.S. Gulf War Veterans: service periods in theater, differential exposures, and persistent unexplained illness. Portland Environmental Hazards Research Centre.
美国海湾战争退伍军人:在战区服役的时间、不同的暴露程度以及持续的不明原因疾病。
- DOI:
- 发表时间:
1998 - 期刊:
- 影响因子:3.5
- 作者:
Peter S Spencer;Linda A. McCauley;Sandra Joos;Michael R. Lasarev;Tomas Schuell;Dennis Bourdette;André Barkhuizen;André Barkhuizen;Wendy Johnston;Daniel Storzbach;Daniel Storzbach;Michael Wynn;Ronald Grewenow - 通讯作者:
Ronald Grewenow
Strategies to assess validity of self-reported exposures during the Persian Gulf War. Portland Environmental Hazards Research Center.
评估波斯湾战争期间自我报告暴露有效性的策略。
- DOI:
- 发表时间:
1999 - 期刊:
- 影响因子:8.3
- 作者:
Linda A. McCauley;Sandra K. Joos;Peter S Spencer;Michael R. Lasarev;Tomas Shuell - 通讯作者:
Tomas Shuell
Using an organizational framework to drive change in nursing education: An action plan for nurse leaders
- DOI:
10.1016/j.outlook.2024.102313 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:
- 作者:
Lisa Muirhead;Benjamin G. Harris;Laura P. Kimble;Nicholas A. Giordano;Linda A. McCauley - 通讯作者:
Linda A. McCauley
Linda A. McCauley的其他文献
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{{ truncateString('Linda A. McCauley', 18)}}的其他基金
Occupational Heat Exposure and Renal Dysfunction
职业热暴露与肾功能障碍
- 批准号:
10176133 - 财政年份:2019
- 资助金额:
$ 80.82万 - 项目类别:
Occupational Heat Exposure and Renal Dysfunction
职业热暴露与肾功能障碍
- 批准号:
10415025 - 财政年份:2019
- 资助金额:
$ 80.82万 - 项目类别:
Occupational Heat Exposure and Renal Dysfunction
职业热暴露与肾功能障碍
- 批准号:
10032547 - 财政年份:2019
- 资助金额:
$ 80.82万 - 项目类别:
Occupational Heat Exposure and Renal Dysfunction
职业热暴露与肾功能障碍
- 批准号:
10669871 - 财政年份:2019
- 资助金额:
$ 80.82万 - 项目类别:
Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions
症状科学、代谢组学和多种慢性病研究中心
- 批准号:
10194616 - 财政年份:2018
- 资助金额:
$ 80.82万 - 项目类别:
Center for the Study of Symptom Science, Metabolomics and Multiple Chronic Conditions
症状科学、代谢组学和多种慢性病研究中心
- 批准号:
10456828 - 财政年份:2018
- 资助金额:
$ 80.82万 - 项目类别:
C-CHEM2: Community Outreach and Translation Core
C-CHEM2:社区外展和翻译核心
- 批准号:
9145195 - 财政年份:2016
- 资助金额:
$ 80.82万 - 项目类别:
Center for Children's Health, the Environment, the Microbiome, and Metabolomics (C-CHEM2)
儿童健康、环境、微生物组和代谢组学中心 (C-CHEM2)
- 批准号:
9145185 - 财政年份:2015
- 资助金额:
$ 80.82万 - 项目类别:
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