Sleep Dysfunction and Neurocognitive Outcomes in Adolescent ADHD

青少年多动症的睡眠障碍和神经认知结果

• 批准号: 10456382
• 负责人: Jessica Ruth Lunsford-Avery
• 金额: $ 5.27万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10456382
• 关键词: Address; Administrative Supplement; Adolescence; Adolescent; Adult; Affect; Applications Grants; Attention deficit hyperactivity disorder; Biological; COVID-19; COVID-19 pandemic; Childhood; Clinical; Data; Data Analyses; Development; Electroencephalography; Emotional; Enrollment; Ensure; Funding; Future; Goals; Grant; Home; Hormonal; Hyperactivity; Impairment; Impulsivity; Intervention; Laboratories; Manuscripts; Measures; Memory; Mentored Patient-Oriented Research Career Development Award; Mentors; Motivation; Neurobiology; Neurocognition; Neurocognitive; Neurocognitive Deficit; Outcome; Parents; Phenotype; Polysomnography; Population; Preparation; Prevention program; Procedures; Protocols documentation; Research; Research Activity; Research Training; Resources; Role; Sampling; Severities; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Social outcome; Subgroup; Symptoms; Testing; Time; Training; Translational Research; Youth; base; career development; computerized data processing; critical developmental period; design; executive function; experience; inattention; innovation; interest; pandemic disease; parent project; phenotypic biomarker; preventive intervention; programs; psychosocial; recruit; research and development; sleep behavior; sleep difficulty; sleep onset; sleep physiology; sleep spindle; social; sustained attention; symposium; treatment program; vigilance

Attention-Deficit/Hyperactivity Disorder (ADHD) in adolescence is frequently predictive of detrimental academic and social outcomes. In part, poor functioning may be due to neurocognitive deficits observed in ADHD; however, the extent of these deficits is variable and the mechanisms contributing to greater impairment in some youth and not others are poorly understood. Sleep disturbance represents one potential contributor to the neurocognitive deficits observed in a subset of youth with ADHD. Specifically, disturbed sleep is prevalent in ADHD and there is considerable overlap between core ADHD features and the neurocognitive correlates of sleep impairment. However, associations between sleep physiology and variable clinical and neurocognitive outcomes in adolescents with ADHD have yet to be investigated. The parent project uses polysomnography to assess sleep disturbance and neurocognitive outcomes in adolescents with ADHD and healthy controls (HC). The primary hypothesis predicts that adolescents with ADHD will display reduced duration, increased latency, increased nocturnal awakenings, reduced delta power, and disrupted sleep spindles compared to HC. Variability within groups is predicted, and we will explore whether there are distinct subgroups with and without sleep problems within the ADHD group. In addition, sleep disturbance is predicted to be associated with poorer neurocognitive and clinical presentations in adolescents with ADHD. If these hypotheses are supported, sleep disturbance may represent a biomarker for phenotypic subtypes of ADHD. Examining this construct may also inform development of prevention and intervention strategies with the potential to impact sleep disturbance and core symptoms of ADHD in adolescents. The career development goal of the parent K23 Mentored Patient- Oriented Research Career Development Award is to broaden Dr. Jessica Lunsford-Avery's expertise in sleep disturbance and neurocognition in adolescents with ADHD. Training objectives include gaining expertise in advanced laboratory-based administration, scoring, and analysis of polysomnographic data; assessment of neurocognitive and clinical correlates of sleep impairment in ADHD; and enhanced understanding of developmental trajectories of sleep in typically developing adolescents and those with ADHD. These objectives are underway through mentoring, research, and coursework, which will result in an independently funded program of research to elucidate the biological mechanisms underlying sleep problems and neurocognitive impairment in ADHD and develop innovative sleep-based interventions targeting core symptoms in this population. The proposed supplement addresses both research and career development objectives and will allow for 1) provision of essential training in scoring of polysomnographic data for spectral analysis and translational research, 2) data processing and analysis, and 3) preparation of manuscripts and R01 grant applications. Moreover, the proposed supplement will offset the loss of time and effort associated with COVID- 19 and will provide the necessary resources to support Dr. Lunsford-Avery's transition to independence.

青春期的注意力缺陷/多动障碍(ADHD)经常预示着有害的学业 和社会结果。在某种程度上，功能低下可能是由于ADHD患者观察到的神经认知缺陷； 然而，这些缺陷的程度是可变的，导致更大损害的机制 一些年轻人，而不是其他人，很难被理解。睡眠障碍是导致睡眠障碍的一个潜在因素 在患有ADHD的一组年轻人中观察到的神经认知缺陷。具体地说，睡眠障碍很普遍。 在ADHD患者中，ADHD的核心特征和神经认知相关因素之间存在相当大的重叠 睡眠障碍。然而，睡眠生理学与不同的临床和神经认知之间的联系 患有ADHD的青少年的结果还有待调查。父项目使用多导睡眠图来 评估患有ADHD的青少年和健康对照组(HC)的睡眠障碍和神经认知结果。 最初的假设预测，患有ADHD的青少年将表现出持续时间缩短，潜伏期延长， 与HC相比，夜间唤醒增加，增量能量减少，睡眠纺锤波中断。 预测了组内的可变性，我们将探索是否存在有和没有的不同子组 ADHD组中的睡眠问题。此外，睡眠障碍被预测与较差的睡眠有关 青少年ADHD的神经认知和临床表现。如果这些假设得到支持，那就睡觉吧 干扰可能是ADHD表型亚型的生物标志物。检查此构造还可以 告知制定预防和干预战略，可能影响睡眠障碍和 青少年ADHD的核心症状。家长K23辅导患者的职业发展目标-- 定向研究职业发展奖是为了拓宽杰西卡·伦斯福德-艾弗里博士在睡眠方面的专业知识 注意缺陷多动障碍青少年的神经认知障碍。培训目标包括获得以下方面的专长 多导睡眠图数据的高级实验室管理、评分和分析.评估 ADHD患者睡眠障碍的神经认知和临床相关性；以及增强对 典型发育期青少年和ADHD患者的睡眠发育轨迹。这些目标 正在通过指导、研究和课程作业进行，这将导致一个独立资助的 阐明睡眠问题和神经认知的生物学机制的研究计划 ADHD的损害，并开发针对核心症状的创新睡眠干预措施 人口。拟议补编涉及研究和职业发展目标，并将 允许1)提供用于频谱分析的多导睡眠图数据评分方面的基本培训 翻译研究，2)数据处理和分析，3)手稿和R01补助金的准备 申请。此外，拟议的补编将抵消与COVID相关的时间和精力的损失- 19并将提供必要的资源，支持伦斯福德-埃弗里博士向独立过渡。

项目成果

Sluggish Cognitive Tempo in Adults Referred for an ADHD Evaluation: A Psychometric Analysis of Self- and Collateral Report.

• DOI: 10.1177/1087054718787894
• 发表时间: 2021-03
• 期刊: Journal of attention disorders
• 影响因子: 3
• 作者: Lunsford-Avery JR;Kollins SH;Mitchell JT
• 通讯作者: Mitchell JT

Regularity and Timing of Sleep Patterns and Behavioral Health Among Adolescents.

• DOI: 10.1097/dbp.0000000000001013
• 发表时间: 2022-05-01
• 期刊: JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
• 影响因子: 2.4
• 作者: Lunsford-Avery, Jessica R.;(Will) Wang, Ke;Kollins, Scott H.;Chung, Richard J.;Keller, Casey;Engelhard, Matthew M.
• 通讯作者: Engelhard, Matthew M.

Overnight Delta Dynamics Associated with Daytime Psychomotor Performance in Adults with Insomnia and Healthy Controls.

• DOI: 10.2147/nss.s330939
• 发表时间: 2022
• 期刊: Nature and science of sleep
• 影响因子: 3.4
• 作者: Lunsford-Avery JR;Edinger JD;Krystal AD
• 通讯作者: Krystal AD

Behavioral Treatment of Insomnia and Sleep Disturbances in School-Aged Children and Adolescents.

• DOI: 10.1016/j.chc.2020.08.006
• 发表时间: 2021-01
• 期刊: Child and adolescent psychiatric clinics of North America
• 影响因子: 2.4
• 作者: Lunsford-Avery JR;Bidopia T;Jackson L;Sloan JS
• 通讯作者: Sloan JS

Sluggish cognitive tempo (SCT) in an adult outpatient sample seeking an attention-deficit/hyperactivity disorder assessment: Age of onset and assessment method impact on SCT rates.

• DOI: 10.1016/j.jpsychires.2020.09.013
• 发表时间: 2020-12
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Mitchell JT;Davis NO;Kollins SH;Lunsford-Avery JR
• 通讯作者: Lunsford-Avery JR