South Texas Alzheimer's Disease Center Imaging Core

南德克萨斯阿尔茨海默病中心影像核心

• 批准号: 10472660
• 负责人: PETER Thornton FOX
• 金额: $ 29.21万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472660
• 关键词: Agreement; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Animals; Architecture; Archives; Arts; Autopsy; Biochemistry; Biomedical Research; Blood Chemical Analysis; Brain; Capital; Clinical; Clinical Trials; Collaborations; Communities; Computers; Consult; Custom; Cyclic GMP; Cyclotrons; Data; Degree program; Development; Diagnostic radiologic examination; Doctor of Philosophy; Doctor' s Degree; Equipment; Etiology; Excision; FDA approved; Faculty; Faculty Recruitment; Fostering; Foxes; Functional Magnetic Resonance Imaging; Generations; Genetic; Goals; Grant; High Performance Computing; Hispanic Populations; Home; Human; Image; Image Analysis; Infrastructure; Institutes; International; Ions; Isotopes; K-Series Research Career Programs; Laboratories; MRI Scans; Machine Learning; Magnetic Resonance Imaging; Measures; Medical; Medical Imaging; Metabolism; Methods; Mission; Morphologic artifacts; Motion; Neurosciences; Performance; Physicians; Physiologic pulse; Play; Population; Positron-Emission Tomography; Postdoctoral Fellow; Production; Protocols documentation; Psychometrics; Publications; Quality Control; RF coil; Radiochemistry; Radiology Specialty; Radiopharmaceuticals; Research; Research Institute; Research Training; Resources; Robotics; Role; Scanning; Science; Scientist; Services; Site; South Texas; Standardization; Statistical Data Interpretation; Stimulus; Structure; Supervision; System; Texas; Training; Training Programs; Training Support; Transcranial magnetic stimulation; Validation; Work; base; brain magnetic resonance imaging; burden of illness; clinical care; clinical center; cluster computing; data management; data sharing; education research; experience; faculty mentor; genetic pedigree; graduate student; graph theory; hemodynamics; human imaging; image archival system; image guided; imaging facilities; imaging modality; imaging program; informatics infrastructure; instrument; instrumentation; magnetic resonance spectroscopic imaging; multi-site trial; multimodality; multiple omics; network models; neuroimaging; neuropathology; novel; post-doctoral training; programs; protocol development; receptor density; recruit; research facility; response; spectroscopic imaging; statistical learning; statistics; tau Proteins; trial design; virtual; web interface

The Imaging Core (IC) highlights the strengths of the South Texas Alzheimer Center (STAC), which has a critical mass of infrastructure, imaging expertise, and training programs. It is comprised of the Research Imaging Institute (RII), the Department of Radiology and the Radiological Sciences Graduate Program (RSGP). The RII is a research unit that has supported biomedical research in South Texas for 30 years, including numerous international collaborations. PI Fox has >100 publications/ multiple grants with Genetics and Multiomics core PI, Blangero at UTRGV. The RII is housed in the same building as the Clinical Core (CC) and Population Neuroscience Core at UTHSA and includes: magnetic resonance imaging and spectroscopy (MR/MRSI) for humans (3-T) and animals (7-T, 12-T); positron-emission tomography (PET) for humans and animals; two medical cyclotrons for PET-isotope production; and, radio-pharmaceutical production facilities, including an FDA-approved (ANDA & IND) cGMP commercial-production facility. Ancillary capabilities include in-scanner performance-control systems (stimulus delivery and response recording); image-guided, robotic transcranial magnetic stimulation (irTMS). RII faculty provide expertise in image acquisition (including radiochemistry and pulse-sequence editing), image preprocessing, and sophisticated analysis, including machine learning, AI. Image archiving, analysis and sharing (XNAT) capabilities are provided by virtual computers, a new on-site high-performance compute cluster (GENIE) and ready access to the Texas Advanced Computing Center. The Department of Radiology provides neuroradiologic expertise (including a fluoroscopic suite dedicated to research LP) and 2 additional 3T MRI and a PET/CT scanner, also in the same building as the CC. The STAC is a site for several clinical trials (AHEAD 3-45, markVCID, GOBS, TARCC) demonstrating ability to acquire high quality MRI (with DTI, CVR, fcMRI), amyloid, tau and FDG PET. We routinely obtain ADNI-3 protocol MRI as part of clinical care and have implemented the protocol across 5 MRI scanners (3 at UTHSA and 1 each at Laredo and Harlingen CC sites). We will obtain these MRI scans on all CC enrollees, annually, and will also obtain amyloid (PIB) and tau (T807, flutaucipir) PET to categorize enrollees using A/T/N criteria. We have recruited a neuroradiologist, radiochemist and computational analyst in the past year. We have implemented a post-mortem whole brain MRI protocol (with Neuropathology core). IC faculty are leaders in multimodal MRI, functional MR and in applying and developing novel image analysis methods to answer questions relevant to ADRD; they are leading MRI harmonization/analyses within CHARGE, iSHARE consortia and in SPRINT-MIND. The RSGP supports the STAC REC by overseeing 3 doctoral degree programs directed by IC core leaders: Neuroscience Imaging (P. Fox), Human Imaging (G. Clarke), and, Diagnostic Radiology (M. Habes) and partners with an R25 Medical Scientist Training Program (MSTP, PI Cavazos who also leads the STAC REC) to train MD/PhD scientists.

成像核心（IC）突出了南德克萨斯阿尔茨海默病中心（STAC）的优势， 拥有大量的基础设施、成像专业知识和培训计划。它包括研究 影像研究所（RII），放射线学系和放射线科学研究生课程 （RSGP）。RII是一个研究单位，30年来一直支持德克萨斯州南部的生物医学研究， 包括许多国际合作。PI Fox拥有超过100篇出版物/遗传学的多项赠款 和UTRGV的Multiomics核心PI Blangero。RII与临床中心位于同一栋大楼内 (CC)和UTHSA的人口神经科学核心，包括：磁共振成像和 人（3-T）和动物（7-T，12-T）的磁共振波谱（MR/MRSI）; 人类和动物;两个用于PET同位素生产的医用回旋加速器;以及放射性药物生产 工厂，包括FDA批准的（ANDA & IND）cGMP商业生产设施。辅助能力 包括扫描仪内性能控制系统（刺激传递和响应记录）;图像引导， 机器人经颅磁刺激（irTMS）。RII教师提供图像采集方面的专业知识（包括 放射化学和脉冲序列编辑），图像预处理和复杂的分析，包括 机器学习，人工智能。图像存档、分析和共享（XNAT）功能由虚拟 计算机，一个新的现场高性能计算集群（GENIE）和随时访问得克萨斯州 高级计算中心。放射科提供神经放射学专业知识（包括 专用于研究LP的X线透视套件）和2台额外的3 T MRI和PET/CT扫描仪，也在同一个 建筑如CC。STAC是几个临床试验的网站（AHEAD 3-45，markVCID，GOBS，TARCC） 证明能够获得高质量的MRI（DTI、CVR、fcMRI）、淀粉样蛋白、tau和FDG PET。我们 作为临床护理的一部分，常规获得ADNI-3方案MRI，并在5次MRI中实施方案 扫描仪（UTHSA 3台，拉雷多和哈林根CC各1台）。我们将获得这些核磁共振扫描对所有 CC每年入组一次，还将获得淀粉样蛋白（PIB）和tau（T807，氟他匹尔）PET进行分类 使用A/T/N标准的入组者。我们招募了一名神经放射学家，放射化学家和计算分析师， 过去一年我们已经实施了死后全脑MRI方案（以神经病理学为核心）。IC 教师是多模态MRI，功能MR以及应用和开发新型图像分析的领导者 回答ADRD相关问题的方法;他们正在领导MRI协调/分析， 充电，iSHARE财团和SPRINT-MIND。RSGP支持STAC REC，监督3 由IC核心领导人指导的博士学位课程：神经科学成像（P. Fox），人类成像（G. Clarke）和诊断放射学（M. Habes）与R25医学科学家培训计划合作 (MSTP PI Cavazos也领导STAC REC）培训MD/PhD科学家。