MECHANISMS OF ACTION OF TMS-INDUCED PERFORMANCE ENCHANCEMENT

TMS 提高成绩的作用机制

• 批准号: 7718757
• 负责人: PETER Thornton FOX
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718757
• 关键词: Acute; Adjuvant; Adjuvant Therapy; Cause of Death; Chronic; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnostic; Functional Magnetic Resonance Imaging; Funding; Grant; Hand; Human; Image; Institution; Invasive; Learning; Light; Measures; Mediating; Mental Depression; Morbidity - disease rate; Motor; Motor Evoked Potentials; Neurologic; Occupational Therapy; Patients; Performance; Personal Satisfaction; Physical therapy; Positron-Emission Tomography; Purpose; Quality of life; Range; Rate; Recruitment Activity; Research; Research Personnel; Residual state; Resources; Site; Source; Stroke; Techniques; Therapeutic; United States National Institutes of Health; developmental disease; improved; knowledge base; motor learning; neuronal excitability; programs; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. BACKGROUND AND OBJECTIVE: The long-range purpose of the research program presented here is to study the mechanisms of action by which TMS enhances human performance. It is well-established that, when properly applied, TMS can alter human performance. The mechanisms of action underlying TMS-induced performance enhancements, both acute and chronic, are not well understood. We hypothesize that the transient performance enhancement induced by single-session TMS is mediated by increased neuronal excitability at the stimulated site (Aim 1), but not by increased connectivity or recruitment. For multi-session TMS, we hypothesize that TMS adjuvant treatment will increase rate of learning and maximum performance achieved in comparison to motor practice alone, but that TMS alone will not improve either parameter of motor performance (Specific Aim 2). We also hypothesize that adjuvant TMS to SMA hand will have a greater effect on motor learning than adjuvant TMS to M1 hand (Aim 2). We hypothesize that for both motor practice alone and TMS adjuvant therapy: 1. rate of learning will be correlated with increased connectivity: and 3. increased excitability will not be correlated with either performance variable (Specific Aim 3). RESEARCH PLAN AND METHODS: The proposal will use several non invasive imaging and electrophysiological techniques. Functional MRI will assess alterations in the volume of cortex recruited during performance. TMS and PET will be used cojointly to detect enhancements in inter-regional connectivity. TMS/PET and electrophysiological measures including motor-evoked potentials (MEP) will be used to detect alterations in neuronal excitability. These proposed experiments will determine the mechanisms of action used by single-session M1-hand TMS enhanced motor performance. They will also determine the efficacy of multi-session M1-hand and SMA-hand TMS as adjuvants to practive-induced enhancement of motor performance. Further, this study will compare the mechanisms of action of practice-induced motor learning, TMS-alone and TMS as a adjuvant for enhancement of motor performance. The research program presented here will create a knowledge base which will inform the rational development of TMS as adjuvant treatment to be used in conjunction with primary therapies in the tratment of neurological, psychiatric and developmental disorders. We predict that the results from the proposed studies will have direct impact on the managemtn of stroke which is the third leading cause of death in the US. Treatment of residual sympomos of stroke is mainly physical and occupational therapy. Applying TMS as an adjunct to physical therapy will reduce morbidity and improve quality of life of stroke patients. The findings from this study will also shed light on the mechanism of action of TMS that is being used as an adjunct therapy in depression. This study does not have therapeutic or diagnostic value to subjects.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景与目的：这里提出的研究计划的长期目的是研究TMS增强人类表现的作用机制。 众所周知，如果应用得当，TMS可以改变人的表现。 TMS引起的性能增强的作用机制，急性和慢性的，还没有很好的理解。 我们假设单次经颅磁刺激诱导的短暂性能增强是由刺激部位神经元兴奋性增加介导的（目的1），而不是由连接性增加或招募介导的。 对于多疗程TMS，我们假设与单独的运动练习相比，TMS辅助治疗将增加学习率和达到的最大性能，但单独的TMS不会改善运动性能的任何参数（具体目标2）。 我们还假设SMA手的辅助TMS对运动学习的影响大于M1手的辅助TMS（目的2）。 我们假设，对于单独的运动训练和TMS辅助治疗：1。 学习率将与增加的连通性相关：以及3. 兴奋性的增加与两个性能变量都不相关（具体目标3）。 研究方法：该提案将使用几种非侵入性成像和电生理技术。 功能性MRI将评估在性能过程中招募的皮质体积的变化。 TMS和PET将共同用于检测区域间连通性的增强情况。 将使用TMS/PET和电生理测量（包括运动诱发电位（MEP））检测神经元兴奋性的变化。 这些拟议的实验将确定单届M1-手TMS增强运动性能所使用的行动机制。 他们还将确定多会话M1-手和SMA-手TMS作为实践诱导的运动表现增强的辅助手段的功效。 此外，本研究将比较练习诱导的运动学习，TMS单独和TMS作为辅助提高运动成绩的作用机制。 这里介绍的研究计划将创建一个知识库，这将为TMS作为辅助治疗的合理发展提供信息，这些辅助治疗将与神经系统，精神病和发育障碍的治疗中的主要治疗结合使用。 我们预测，拟议研究的结果将对卒中的管理产生直接影响，卒中是美国第三大死亡原因。 中风后遗症的治疗主要是物理治疗和作业治疗。 将经颅磁刺激作为物理治疗的辅助手段，将降低脑卒中患者的发病率，提高其生活质量。 这项研究的结果也将揭示TMS的作用机制，TMS被用作抑郁症的辅助治疗。 本研究对受试者无治疗或诊断价值。