CAP - Consortium to Alleviate PTSD - STVHCS Neuroimaging Core

CAP - 减轻 PTSD 联盟 - STVHCS 神经影像核心

• 批准号: 8770323
• 负责人: PETER Thornton FOX
• 金额: --
• 依托单位: SOUTH TEXAS VETERANS HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8770323
• 关键词: Address; Advisory Committees; Alcohol or Other Drugs use; Animals; Biological Markers; Biological Models; Characteristics; Clinical Trials; Cognitive Therapy; Communication; Data; Diagnosis; Diagnostic; Diagnostic Sensitivity; Disclosure; Electronics; Employee Strikes; Ensure; Epidemiology; Equilibrium; Etiology; Evaluation; Exposure to; Fostering; Foundations; Foxes; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Genomics; Goals; Government; Guidelines; Headache; Image; Image Analysis; Impairment; Individual; Institutes; Institution; Intervention; Ketamine; Learning; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mental Depression; Mental Health; Meta-Analysis; Methods; Military Personnel; Modeling; Neurobiology; Neurocognitive; Pain; Pathology; Personal Satisfaction; Persons; Pharmacotherapy; Positioning Attribute; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Prevention; Prevention strategy; Preventive; Principal Investigator; Printing; Procedures; Process; Productivity; Proteomics; Protocols documentation; Psychometrics; Publications; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Review Committee; Role; Services; Site; Sleep disturbances; Sleeplessness; Stress; Structure; Suicide; System; Teleconferences; Tracer; Training; Veterans; Work; base; behavioral health; combat; cost; data acquisition; design; imaging modality; improved; interest; meetings; member; multidisciplinary; neuroimaging; neurophysiology; novel; organizational structure; outcome forecast; physical conditioning; post-traumatic stress; prevent; prognostic; quality assurance; research study; response; success; tomography; treatment response

Neuroimaging Core The Neuroimaging Core builds upon a strong foundation developed over the past four years as a STRONG STAR core. Dr. Fox is currently Director of the STRONG STAR Neuroimaging Core; he will continue in this role for the STRONG STAR-CAP, being joined by Dr. Krystal as Co-Director. The overall objective of the Neuroimaging Core is to foster the use of advanced neuroimaging methods in the study of PTSD and related conditions for the purposes of (1) investigating the underlying pathology (using structural imaging) and pathophysiology (using functional imaging); (2) assessing and enhancing the diagnostic sensitivity of imaging methods; (3) investigating the neurophysiology of treatment response (image-based response assessment); and (4) ensuring comparability of imaging data acquisition and pre-processing between sites. Neuroimaging methods utilized include structural and functional magnetic resonance imaging (MRI and fMRI), magnetic resonance spectroscopy (MRS), and position emission tomography (PET). These methods are used in the context of extensive neurocognitive assessments focused on evaluation of PTSD-related impairments, with psychometric scores being used as probes for voxel-wise and region-of-interest-based analyses. The Neuroimaging Core provides standardized core image-acquisition and image-analysis protocols (both structural and functional), as well as developing project-specific neuroimaging probes. In the ongoing STRONG STAR Consortium, neuroimaging imaging assessments focused on modeling the system-level effects of PTSD (e.g., Ramage et al., 2012) and characterizing the mechanisms of action of cognitive and behavioral therapy. In the current proposal, emphasis is placed on the mechanisms of action of Prolonged Exposure (PE; project 1), on pharmacotherapy (ketamine; Project 1) and on insomnia (Project 7). Previously based solely at UTHSCSA's Research Imaging Institute, the Neuroimaging Core now incorporates a second world-class neuroimaging facility, i.e., that at Yale. In doing so, the Neuroimaging Core builds upon an ongoing collaborative relationship with Yale, focused on high-field, small-animal imaging. Image-analysis capabilities at both core components are outstanding and complementary, with the Research Imaging Institute having exceptional strengths in meta- analysis and system-level modeling construction and with Yale having exceptional strengths in analysis of pharmacologic interventions and tracer-based imaging methods.

神经成像的核心