ASSIST: Child Apraxia Speech Treatment
协助:儿童失用症言语治疗
基本信息
- 批准号:10383670
- 负责人:
- 金额:$ 38.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-15 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectApraxiasAreaChildChildhoodClientClinicalComplexControl GroupsDevelopmental apraxiaExperimental DesignsFamilyGenetic TranscriptionGoalsHealthcare SystemsHourImpairmentIndividualInterventionLanguageLearningMeasuresMethodologyMethodsMotivationMotorMotor SkillsMovementNational Institute on Deafness and Other Communication DisordersNeuronal PlasticityOutcomeOutcome MeasureParentsPathologistPhasePopulationPrevalenceQuality of lifeRandomizedRecommendationReportingResearchResearch DesignResourcesSample SizeSchoolsSelection for TreatmentsSeriesSocial DevelopmentSocial FunctioningSocietiesSpeechSpeech DisordersSpeech IntelligibilitySpeech TherapyStrategic PlanningTestingTranslatingbaseclinical decision-makingcomparativedesigneconomic outcomeeffective therapyefficacy trialevidence basefunctional outcomeslexicalliteracymotor learningoptimal treatmentsphase 1 studyphase II trialphase III trialprimary outcomeprogramsspeech accuracysuccesstreatment effecttreatment grouptreatment programtreatment responsevirtual
项目摘要
Project Summary
Childhood apraxia of speech (CAS) is a pediatric motor speech disorder that impairs the planning of
movements needed for intelligible speech. CAS may limit literacy, academic and economic outcomes and
participation in society. Approximately 40,000 to 160,000 children under 10 have CAS in the US, and over 60%
of school-based speech-language pathologists have children with CAS on their caseload, with on average 3
children per caseload. Children with CAS often show little or slow progress in standard speech therapy, which
has led to recommendations for intensive intervention and calls for systematic research to optimize outcomes.
Given the limited resources in clinical settings, it is imperative to maximize impact of these limited resources for
children with CAS. This proposal fits with NIDCD’s Strategic Plan in that it aims to develop and test an effective
treatment for an explicitly noted understudied population (CAS).
Various treatment approaches for CAS exist, with integral stimulation treatment (“watch me, listen to me, say
what I say”) being the only treatment method to date with independently replicated support. Nevertheless, the
current evidence base is limited both in study quality and scope. In terms of study quality, all studies to date have
involved single-case experimental designs with small sample sizes and varying methodological rigor. In terms of
scope, the extant studies vary considerably with respect to important treatment parameters that may critically
impact outcomes. Two such important yet poorly understood parameters relate to optimal target selection and
optimal treatment intensity. Another limitation of scope is that virtually all studies have relied exclusively on
impairment-level outcome measures, and have not included more functional outcome measures related to
activity and participation. For these reasons, speech-language pathologists lack adequate information to make
clinical decisions for their clients.
The proposed research is a Phase I study that tests initial efficacy and optimal parameters of a theoretically
based integral stimulation treatment called ASSIST (Apraxia of Speech Systematic Integral Stimulation
Treatment). In three small randomized group design studies, children (N=20 per study) receive 16 hours of
individual ASSIST. The three studies systematically investigate treatment intensity (2 vs. 4 weeks) and two
critical aspects of target selection: complexity (simple vs. complex target) and lexicality (words vs. nonwords).
Each study also systematically examines the effect of treatment on functional outcome measures, including
parent ratings of intelligibility and communicative participation, and objective intelligibility measures obtained
from unfamiliar listeners. Thus, this research will gather vital information for a Phase II trial of preliminary efficacy
and contribute high-quality evidence that will help speech-language pathologists make evidence-based clinical
decisions. The long term goal of this research program is to develop optimally effective treatments to maximize
outcomes and communicative quality of life for the many children with CAS and their families.
项目概要
儿童言语失用症 (CAS) 是一种儿童运动性言语障碍,会损害儿童的规划能力
可理解的言语所需的动作。 CAS 可能会限制识字率、学术和经济成果,
参与社会。在美国,大约有 40,000 至 160,000 名 10 岁以下儿童患有 CAS,其中超过 60%
的学校言语病理学家的病例中有患有 CAS 的孩子,平均有 3
每宗儿童数。患有 CAS 的儿童在标准言语治疗中通常表现出很少或缓慢的进展,这
引发了强化干预的建议,并呼吁进行系统研究以优化结果。
鉴于临床环境中的资源有限,必须最大限度地发挥这些有限资源的影响
患有 CAS 的儿童。该提案符合 NIDCD 的战略计划,旨在开发和测试有效的
针对明确指出的待研究人群 (CAS) 的治疗。
CAS 存在多种治疗方法,其中包括整体刺激治疗(“看我、听我说、说
我所说的”)是迄今为止唯一具有独立复制支持的治疗方法。
目前的证据基础在研究质量和范围上都有限。就研究质量而言,迄今为止的所有研究都
涉及小样本和不同方法严格性的单案例实验设计。按照
范围,现有的研究在重要的治疗参数方面差异很大,这些参数可能会严重影响治疗效果。
影响结果。两个如此重要但知之甚少的参数与最佳目标选择和
最佳治疗强度。范围的另一个限制是几乎所有研究都完全依赖于
损伤水平的结果测量,并且没有包括与以下相关的更多功能性结果测量
活动和参与。由于这些原因,言语病理学家缺乏足够的信息来做出
为客户做出临床决策。
拟议的研究是一项第一阶段研究,测试理论上的初始功效和最佳参数
基于积分刺激治疗的 ASSIST(言语失用症系统积分刺激)
治疗)。在三项小型随机分组设计研究中,儿童(每项研究 N=20)接受 16 小时的学习
个人协助。这三项研究系统地调查了治疗强度(2 周与 4 周),其中两项研究
目标选择的关键方面:复杂性(简单目标与复杂目标)和词汇性(单词与非单词)。
每项研究还系统地检验了治疗对功能结果指标的影响,包括
家长对清晰度和交流参与的评分,以及获得的客观清晰度测量
来自不熟悉的听众。因此,这项研究将为初步疗效的 II 期试验收集重要信息
并提供高质量的证据,帮助言语病理学家做出基于证据的临床
决定。该研究计划的长期目标是开发最佳有效的治疗方法,以最大限度地提高治疗效果。
许多 CAS 儿童及其家人的治疗结果和沟通生活质量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Edwin Maas其他文献
Edwin Maas的其他文献
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{{ truncateString('Edwin Maas', 18)}}的其他基金
Psycholinguistic Investigations of Development and Disorders of Speech Production
言语产生的发展和障碍的心理语言学研究
- 批准号:
8246481 - 财政年份:2010
- 资助金额:
$ 38.23万 - 项目类别:
Psycholinguistic Investigations of Development and Disorders of Speech Production
言语产生的发展和障碍的心理语言学研究
- 批准号:
8444483 - 财政年份:2010
- 资助金额:
$ 38.23万 - 项目类别:
Psycholinguistic Investigations of Development and Disorders of Speech Production
言语产生的发展和障碍的心理语言学研究
- 批准号:
7892834 - 财政年份:2010
- 资助金额:
$ 38.23万 - 项目类别:
Psycholinguistic Investigations of Development and Disorders of Speech Production
言语产生的发展和障碍的心理语言学研究
- 批准号:
8642628 - 财政年份:2010
- 资助金额:
$ 38.23万 - 项目类别:
Psycholinguistic Investigations of Development and Disorders of Speech Production
言语产生的发展和障碍的心理语言学研究
- 批准号:
8039099 - 财政年份:2010
- 资助金额:
$ 38.23万 - 项目类别:
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