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Incident Vascular Brain Injury, Probable Alzheimer's Disease, and Cognitive Change in Elderly American Indians

老年印第安人的血管性脑损伤、可能的阿尔茨海默病和认知变化

基本信息

批准号：
10382295
负责人：
Astrid M Suchy-Dicey
金额：
$ 12.56万
依托单位：
WASHINGTON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10382295
关键词：
Address African American African American population Alzheimer&apos s Disease American Indians Brain Brain Pathology Cephalic Cerebrovascular Disorders Cerebrovascular Trauma Cessation of life Clinical Cluster Analysis Cognitive Cohort Studies Data Data Collection Data Set Dementia Development Plans Diagnostic Disease Disease Progression Educational workshop Elderly Elements Environment Ethnic Origin Ethnic group Etiology Evaluation Event Evidence based intervention Exclusion Frequencies Functional Magnetic Resonance Imaging Funding Future General Population Geography Grant Health Healthcare Systems Image Impaired cognition Incidence Individual Knowledge Longitudinal cohort study Magnetic Resonance Imaging Measures Medical Genetics Memory Mental Depression Mentors Methods Minority Groups Minority Health Research Monitor National Institute of Neurological Disorders and Stroke National Institute on Aging Nerve Degeneration Neuroepidemiology Neurological observations Neuropsychological Tests Neuropsychology Not Hispanic or Latino Outcome Participant Pathology Patient risk Pattern Persons Population Positioning Attribute Prevalence Prevention Protocols documentation Quality of life Race Recording of previous events Research Research Personnel Resources Risk Risk Factors Sampling Severities Social Environment Standardization Stroke Subgroup Targeted Research Thinking Time Tribes Ursidae Family aged aging brain analytical method burden of illness cardiovascular health cardiovascular risk factor career development caucasian American cerebral atrophy clinical examination clinical risk cognitive change cognitive testing cohort disability disease disparity disorder prevention environmental stressor experience follow-up health disparity health disparity populations high risk innovation mild cognitive impairment neuroimaging neuropathology novel population based pre-clinical preservation prevent psychosocial recruit rural residence skills social stressor socioeconomics success vascular contributions

项目摘要

PROJECT SUMMARY / ABSTRACT A workshop convened in 2013 by National Institute of Aging and the National Institute of Neurological Diseases and Stroke prioritized research on cognitive impairment of multiple etiologies, contributions of vascular brain injury (VBI) to neurodegeneration and Alzheimer's Disease (AD), and disparities involving race, ethnicity, socioeconomics, and rural residence. VBI is a leading cause of accelerated brain aging and a major risk factor for stroke, cognitive decline, depression, and probable Alzheimer's disease (AD). However, few studies have evaluated VBI, cognitive impairment, and AD in American Indians (AIs), who bear a heavy burden of risk factors for these conditions. This exclusion is unfortunate, since the distinctive history, risk profiles, environmental stressors, social environments, and healthcare systems of AIs likely result in patterns of disease that differ substantially from other populations. Our research team has conducted the only cohort study to date of covert VBI in AIs. In 2010-2013, Cerebrovascular Disease and its Consequences in American Indians study completed standardized clinical examinations, neuropsychological testing, and cranial MRI on more than 1,000 AIs aged 64-95 years from 10 tribes in 3 states. In 2016, we began re-examination of surviving participants using the same protocols, augmented by assessment for probable AD. However, the particular grant mechanism from the National Institute on Aging that provides funding for this follow-up examination is limited to data collection, with no resources allocated for analysis. In this proposal, we will capitalize on the accumulated longitudinal data to apply sophisticated imaging and analysis methods to quantify and evaluate associations for incident VBI, neurodegeneration, and changes in cognitive status in this elderly minority population. Our Specific Aims are to: (1) establish normative and diagnostic standards for mild cognitive impairment and dementia in elderly AIs, and evaluate associations and determinants for incident VBI, cerebral atrophy, cognitive decline, and probable AD; (2) conduct cluster analyses to identify novel neuroimaging profiles that predict subgroups of elderly AIs at highest risk for cerebral atrophy, cognitive decline, and probable AD; and (3) complete a rigorous career development plan that will position the applicant as an independent investigator and leader in innovative neuroepidemiology research with minority populations. This proposal leverages a timely opportunity to generate the first population-based estimates of and address novel scientific questions on VBI and cognitive impairment in AIs, a minority population with pervasive health disparities.

项目摘要/摘要